Teaching gene-environment interaction concepts with narrative vignettes: Effects on knowledge, stigma, and behavior motivation.

Gene-environment interaction (GxE) concepts underlie a proper understanding of complex disease risk and risk-reducing behavior. Communicating GxE concepts is a challenge. This study designed an educational intervention that communicated GxE concepts in the context of eating behavior and its impact on weight, and tested its efficacy in changing knowledge, stigma, and behavior motivation. The study also explored whether different framings of GxE education and matching frames with individual eating tendencies would result in stronger intervention impact. The experiment included four GxE education conditions and a control condition unrelated to GxE concepts. In the education conditions, participants watched a video introducing GxE concepts then one of four narrative vignettes depicting how a character's experience with eating hyperpalatable or bitter tasting food (reward-based eating drive vs. bitter taste perception scenario) is influenced by genetic or environmental variations (genetic vs. environmental framings). The education intervention increased GxE knowledge, genetic causal attributions, and empathetic concern. Mediation analyses suggest that causal attributions, particularly to genetics and willpower, are key factors that drive downstream stigma and eating behavior outcomes and could be targeted in future interventions. Tailoring GxE education frames to individual traits may lead to more meaningful outcomes. For example, genetic (vs. environmental) framed GxE education may reduce stigma toward individuals with certain eating tendencies among individuals without such tendencies. GxE education interventions would be most likely to achieve desired outcomes such as reducing stigma if they target certain causal beliefs and are strategically tailored to individual attributes.

Addressing challenges to carrying out intervention programs with youth populations: Successes and strategies.

We identify five challenges notoriously faced by researchers conducting youth intervention studies: access to the target population, successful recruitment, ensuring continued attendance, promoting engaged, enthused, and task-focused participation, and efficient data collection. To ensure research quality, we have devised strategies to address these obstacles. Successes and lessons are included from The Compass Project (TCP), a 9-week morality strengthening program designed to facilitate positive attitudinal and behavioral outcomes in young people. Despite four of the five identified challenges being overcome in TCP, the fifth challenge of data collection was insurmountable as many participants failed to complete questionnaire scales. We propose that researchers build on our success by building rapport and trust with participants and youth organizations and building a participant sense of community, and improve upon our design by scrutinizing the format, accessibility, and length of data measures. Ultimately, tests of whether intervention programs can result in positive outcomes in the lives of young people hinge on adequately overcoming the identified challenges. Implementation of the proposed strategies will be instrumental to allow for meaningful and powerful statistical analyses to more accurately gauge the positive impact of intervention programs on young people's lives.

Evaluating eating behavior traits of virtual targets: Attitudes and empathy.

There are many common stereotypes related to food consumption and eating behaviors that are considered indicative of one's personal character. Negative evaluations of an individual based on their eating behaviors may lead to stigmatization and other harmful psychosocial outcomes. Using vignette scenarios, we examined 582 participants' attitudes towards two target characters who exhibited bitter food dislike and high reward-based eating drive respectively. In open-ended text responses, participants were more likely to respond negatively and use stigmatizing language when describing the character with high reward-based eating drive versus the character with bitter food dislike. In addition, empathic responses depended on whether participants believed they, themselves, exhibited reward-based eating drive. Participants tended to be more empathetic and more positive towards the target who shared their own reward-based eating behaviors. Interestingly, the same was not true for those who shared bitter food distaste. These results suggest that eating behaviors that are perceived as more controllable and unusual may be more negatively perceived. Targeted education or support to reduce negative attitudes about such traits may be beneficial.

Using Educational Videos and Perspective-Taking to Communicate Gene-By-Environment Interaction Concepts about Eating Behavior: Effects on Empathy and Weight Stigma.

OBJECTIVE: This study investigated whether education about gene-by-environment interaction (G × E) concepts could improve G × E knowledge and positively affect empathy and weight stigma. DESIGN: We conducted a randomized trial using a 2 × 2 between-subjects design. SETTING: Online. PARTICIPANTS: Five hundred eighty-two American participants from the Prolific platform. INTERVENTION: Participants were randomly assigned to watch an educational or a control video. Participants then watched a set of vignette scenarios that depicted what it is like to have a predisposition toward obesogenic eating behaviors from either a first-person or third-person perspective. MAIN OUTCOME MEASURE(S): Participants completed questionnaires measuring G × E knowledge, causal attributions, weight stigma, and empathy postintervention. ANALYSIS: Two-by-two between-subjects ANOVAs and exploratory mediation analyses were conducted. RESULTS: Participants who watched the educational video demonstrated greater G × E knowledge, reported higher empathy toward the characters in the vignette scenarios and held fewer stigmatizing attitudes (notably blame) toward individuals with higher weight. Exploratory mediation analyses indicated that the educational video led to these positive downstream effects by increasing the extent to which participants attributed genetic causes to eating behaviors. CONCLUSIONS AND IMPLICATIONS: Education about G × E causes of eating behaviors can have beneficial downstream effects on attitudes toward people with higher weight.

Cybersickness Variability by Race: Findings From 6 Studies and a Mini Meta-analysis.

BACKGROUND: With the influx of medical virtual reality (VR) technologies, cybersickness has transitioned from a nuisance experienced during leisure activities to a potential safety and efficacy concern for patients and clinicians. To improve health equity, it is important to understand any potential differences in cybersickness propensity among demographic groups, including racial groups. OBJECTIVE: This study aims to explore whether cybersickness propensity differs across racial groups. METHODS: We collected self-reported cybersickness ratings from 6 racially diverse independent samples within 1 laboratory group (N=931). In these studies, the participants were asked to perform tasks in VR such as traversing environments, pointing at and selecting objects, and interacting with virtual humans. RESULTS: Significant racial differences in cybersickness were found in 50% (3/6) of studies. A mini meta-analysis revealed that, on average, Black participants reported approximately one-third of SD less cybersickness than White participants (Cohen d=-0.31; P<.001), regardless of the nature of the VR experience. There was no overall difference in reported cybersickness between the Asian and White participants (Cohen d=-0.11; P=.51). CONCLUSIONS: Racial differences in cybersickness indicate that researchers, practitioners, and regulators should consider patient demographics when evaluating VR health intervention outcomes. These findings lay the groundwork for future studies that may explore racial differences in cybersickness directly.

Exploring the impact of genetic beliefs about specific eating behaviors on dietary self-efficacy.

Future personalized approaches to weight management are likely to include consideration of genetic influences on eating behaviors. This study explores whether genetic beliefs about eating behaviors influence dietary self-efficacy and confidence. In a survey of 261 individuals of various weight statuses, we find that endorsing genetic causes of two specific eating behaviors (taste preference and disinhibition) predicts poorer dietary self-efficacy for people who exhibit these eating behaviors. This suggests there may be utility to considering eating behaviors individually when it comes to predicting the influence of genetic information provision in the service of precision medicine interventions. Individuals with high disinhibited eating and/or bitter taster status may be particularly sensitive to interpreting genetic predisposition information in ways that undercut self-efficacy and confidence.

How cognitive and emotional empathy relate to rational thinking: empirical evidence and meta-analysis.

Empathy is frequently described in opposition to rationality. Yet in two studies, we demonstrate that the relationship between rationality and empathy is nuanced and likely context dependent. Study 1 reports correlational data from two American samples and Study 2 presents a meta-analysis of existing literature (k = 22). We demonstrate that various types of cognitive empathy (perspective-taking, emotion recognition, and fantasy) are positively correlated with self-reported rationality, but unrelated to rational performance. In contrast, types of emotional empathy (empathic concern, personal distress, and emotion contagion) are generally negatively correlated with performance measures of rationality, but their relationships with self-reported rationality are divergent. Although these results do not settle the debate on empathy and rationality, they challenge the opposing domains hypothesis and provide tentative support for a dual-process model of empathy. Overall, these results indicate that the relationship between rationality and empathy differs depending upon how rationality and empathy are measured.

Helpful and Hurtful Empathy: How the Interplay of Empathy, Shame, and Anger Predicts Responses to Hypothetical Rape Disclosures.

Responses to rape victims, although often helpful, can be hurtful and hinder victims' health and recovery. Adopting a multidimensional approach to dispositional empathy, this research investigated how different subfacets of empathy predict responses to hypothetical rape victims. Before reading a sexual assault scenario, 282 participants completed measures of cognitive and emotional empathy. Participants' subsequent emotional arousal was measured by self-report, as were their intentions to help, avoid, or blame the victim. A path model demonstrated that dispositional empathy predicted behavioral intentions toward hypothetical rape victims by altering their vulnerability to experience shame or anger. People who tended to feel personal distress were more likely to mirror rape victims' assumed shame. Due to its antisocial nature, experiencing shame, in turn, led to hurtful behaviors such as blaming or distancing oneself from the victim. On the other hand, people who tended to feel empathic concern were more likely to feel anger on behalf of the victim following a rape disclosure. Anger is a motivating force for action and promotes helping behavior. A second study demonstrated that these results appear unique to rape disclosure, namely, participants reactions to nonsexual assault were unsuccessfully captured by this model. Understanding how empathetic arousal of shame can lead to hurtful intentions toward rape victims has important implications for future interventions: Programs that draw attention to the shame or humiliation experienced by rape victims may do more harm than good. For instance, some anti-rape campaigns portray pictures of women covering their faces. These campaigns, however well intentioned, may discourage people from helping victims because they may evoke feelings of shame in the perceiver. On the other hand, societal movements, such as the #Metoo movement, may be particularly effective by reducing the shame surrounding sexual assault and promote helpful behaviors.

Virtual Reality Expands the Toolkit for Conducting Health Psychology Research.

Virtual reality (VR) has become a readily available consumer technology, strengthening its promise as a research tool for health psychology. We identify five key strengths of VR-based research: data collection, realism, experimental control, adaptability, and mobility (DREAM). We review how these advantages allow researchers to investigate behavioral, psychological, and social processes related to health and well-being in novel ways, by using VR as both a stimulus and a measurement tool. We also describe challenges facing VR research and potential strategies researchers can use to mitigate them. In addition to reviewing existing research, we hope to inspire researchers to consider ways in which VR might be used in future to augment their own research programs or answer currently impracticable research questions in health psychology.

The effect of exposure to fiction on attributional complexity, egocentric bias and accuracy in social perception.

We investigated the effects of long-term exposure to literary and popular fiction on attributional complexity, egocentric bias and accuracy. Results of a pre-registered study showed that exposure to literary fiction is positively associated with scores on the attributional complexity scale. Literary fiction is also associated with accuracy in mentalizing, measured via the Reading the Mind in the Eyes test, and with accuracy in predicting average social attitudes. The predicted negative association between literary fiction and egocentric bias emerged only when education and gender were controlled for-a covariance analysis that was not pre-registered. Exposure to popular fiction is associated solely with attributional complexity, but negatively. We discuss the significance of these findings in the context of the emerging literature regarding the relationship between fiction and social cognition.

Toward a psychology of Homo sapiens: Making psychological science more representative of the human population.

Two primary goals of psychological science should be to understand what aspects of human psychology are universal and the way that context and culture produce variability. This requires that we take into account the importance of culture and context in the way that we write our papers and in the types of populations that we sample. However, most research published in our leading journals has relied on sampling WEIRD (Western, educated, industrialized, rich, and democratic) populations. One might expect that our scholarly work and editorial choices would by now reflect the knowledge that Western populations may not be representative of humans generally with respect to any given psychological phenomenon. However, as we show here, almost all research published by one of our leading journals, Psychological Science, relies on Western samples and uses these data in an unreflective way to make inferences about humans in general. To take us forward, we offer a set of concrete proposals for authors, journal editors, and reviewers that may lead to a psychological science that is more representative of the human condition.

Variations in Progression and Regression of Precancerous Lesions of the Uterine Cervix on Cytology Testing Among Women of Different Races.

Background: Although not incorporated into current cervical cancer screening guidelines, racial differences are known to persist in both occurrence of and outcomes related to cervical cancer. Objective: To compare the differences in progression and regression of precancerous lesions of the uterine cervix on cervical cytologic analysis among women of different races who adhered to cervical cancer screening recommendations and follow-up. Methods: Retrospective cohort study comparing differences in precancerous lesion diagnoses for patients receiving adequate evaluation according to the American Society for Colposcopy and Cervical Pathology guidelines. The authors fit Markov multistate models to estimate self-reported race-specific expected wait times and hazard ratios for each possible regression and progression and compared a race model with an intercept-only model using a likelihood ratio test. Results: The sample included 5472 women receiving a Papanicolaou test between January 2006 and September 2016, contributing a total of 24,316 person-years of follow-up. Of 21 hazard ratios tested for significance, the following 4 hazard ratios (95% CIs) were statistically significant: atypical squamous cells of undetermined significance (ASC-US) progression to low-grade squamous intraepithelial lesion (LSIL) for Hispanic patients (0.72; 95% CI, 0.54-0.96); LSIL regression to ASC-US for Hispanic patients (1.55; 95% CI, 1.04-2.31), LSIL regression to ASC-US for Asian patients (1.91; 95% CI, 1.08-3.36), and high-grade squamous intraepithelial lesion regression to LSIL for black patients (0.39; 95% CI, 0.16-0.96). There is an observed trend that all racial groups other than white had a slower rate of progression from ASC-US to LSIL, with Hispanics having demonstrated the slowest rate from ASC-US to LSIL. Hispanics also demonstrated the fastest rate from LSIL to HSIL when compared with all other race categories. In regressions, blacks had the slowest rate of regression from HSIL to LSIL, and Asians had the fastest rate from LSIL to ASC-US. The Hispanic group demonstrated the fastest expected progression (17.6 months; 95% CI, 11.5-25.5), as well as the fastest regression (27.6 months; 95% CI, 21.5-35.6), and the black group has the slowest expected times for both progression (28.1 months; 95% CI, 14.6-47.2) and regression (49 months; 95% CI, 29.1-86.2). The number of visits (1 vs ≥2) in the study was differentially distributed both by race (P=.033) and by last diagnosis (P<.001). Conclusion: Variations in precancerous lesions of the uterine cervix are not uniform across races.

Measuring Multidimensional Empathy: Theoretical and Practical Considerations for Osteopathic Medical Researchers.

Osteopathic physicians are increasingly recognizing the importance of empathy for improving patient satisfaction and clinical outcomes. This review advocates for a multidimensional perspective of empathy, encompassing both affective and cognitive empathy, and highlights situational and dispositional factors relevant to the curtailment of empathy. A review of the utility of self-report, behavioral, and physiological measures that researchers may use to quantify empathy in further research is also provided. The authors encourage members of the osteopathic medical profession to embrace a fuller understanding of empathy.