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Trop Med Int Health ; 18(12): 1539-46, 2013 Dec.
Article in English | MEDLINE | ID: mdl-24134458

ABSTRACT

OBJECTIVES: To evaluate the occurrence of low bone mineral density (BMD) and its relationship with clinical and laboratorial characteristics in children and young adults with sickle cell anaemia living in Northeast-Brazil, and to assess the role of radiography in diagnosing low BMD. METHODS: Bone mineral density of lumbar spine was measured by dual energy X-ray absorptiometry (DXA) in 27 patients with Sickle cell anaemia (SCA) aged 7-28 years. Clinical history, calcium and calorie intake, laboratory measurements, anthropometrics and pubertal development were assessed, and X-rays were obtained. Z-scores and T-scores for weight, height, Body Mass Index (BMI) and BMD were calculated using age and gender matched reference data. RESULTS: Mean lumbar spine BMD Z-scores and T-scores were -1.81 SD in boys and -0.80 SD in girls. BMD Z-scores were below -2 SD in 33.3% of girls and in 46.7% of boys. Low BMD (<-2 SD) occurred significantly more in patients with low height-for-age (P = 0.02), low weight-for-age (P = 0.001) and low BMI-for-age (P = 0.006). No significant relationships were found between BMD and other clinical and laboratory parameters. Radiography had a sensitivity of 75% and a specificity of 36% to detect low BMD, and was considered not useful in this context. CONCLUSIONS: Patients with low height and/or low weight-for-age seem to be at high risk for developing low BMD.


Subject(s)
Anemia, Sickle Cell/physiopathology , Bone Density , Growth Disorders/etiology , Puberty , Adolescent , Adult , Anemia, Sickle Cell/complications , Anemia, Sickle Cell/pathology , Body Height , Body Mass Index , Body Weight , Brazil , Child , Female , Growth Disorders/pathology , Growth Disorders/physiopathology , Humans , Lumbar Vertebrae/pathology , Male , Young Adult
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