Subject(s)
Dermatitis, Atopic/therapy , Food Hypersensitivity/therapy , Child , Dermatitis, Atopic/etiology , Dermatitis, Atopic/immunology , Desensitization, Immunologic , Diet , Filaggrin Proteins , Food Hypersensitivity/diagnosis , Food Hypersensitivity/etiology , Food Hypersensitivity/immunology , Humans , Immunoglobulin E/blood , Immunotherapy , Intermediate Filament Proteins/genetics , Mutation , Prognosis , Risk Factors , Skin Tests , T-Lymphocytes/physiologyABSTRACT
A 55-year-old male presented with back pain and slightly tender annular plaques with central ulceration on his face. A skin biopsy revealed scattered yeast with broad based buds. A CT scan of the abdomen revealed a pathologic T12 fracture. Tissue obtained from the spine confirmed budding yeasts. The patient was diagnosed with disseminated blastomycosis. The patient was treated with amphotericin and itraconazole and completely recovered.
Subject(s)
Blastomycosis/pathology , Facial Dermatoses/pathology , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Biopsy , Blastomycosis/drug therapy , Facial Dermatoses/drug therapy , Humans , Male , Middle Aged , Skin/pathology , Spinal Fractures/diagnosis , Treatment OutcomeABSTRACT
A 55-year-old male presented with back pain and slightly tender annular plaques with central ulceration on his face. A skin biopsy revealed scattered yeast with broad based buds. A CT scan of the abdomen revealed a pathologic T12 fracture. Tissue obtained from the spine confirmed budding yeasts. The patient was diagnosed with disseminated blastomycosis. The patient was treated with amphotericin and itraconazole and completely recovered. .
Paciente do sexo masculino, com 55 anos de idade, compareceu ao ambulatório com dores na costa e placas anulares ligeiramente sensíveis, com ulceração central na face. Uma biópsia cutânea revelou levedura disseminada, com brotos de base larga. A tomografia computadorizada do abdômen revelou uma fratura patológica da T12. Amostra de tecido obtido da coluna vertebral confirmou levedura em fase de brotamento. O paciente foi diagnosticado com blastomicose disseminada. Após tratamento com anfotericina e itraconazol, o paciente teve recuperação completa. .
Subject(s)
Humans , Male , Middle Aged , Blastomycosis/pathology , Facial Dermatoses/pathology , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Biopsy , Blastomycosis/drug therapy , Facial Dermatoses/drug therapy , Skin/pathology , Spinal Fractures/diagnosis , Treatment OutcomeABSTRACT
Miliaria is a disorder of the eccrine sweat glands which occurs in conditions of increased heat and humidity. It can be associated with persistent febrile states as well as with certain drugs. We presented a 40 year-old female with myelodysplastic syndrome and progression to acute myelogenous leukemia who was admitted to the hospital for chemotherapy induction. The patient was treated with idarubicin and cytarabine. She became pancytopenic and developed neutropenic fever and was started on vancomycin and cefepime, but was persistently febrile with night sweats. Five days into her fevers, she developed diffuse, nonpruritic and fragile vesicles together with drenching nightsweats. The patient's exanthem was diagnosed as Miliaria crystallina, most probably induced by neutropenic fever and idarubucin exposure.
Subject(s)
Antibiotics, Antineoplastic/adverse effects , Fever/etiology , Idarubicin/adverse effects , Miliaria/chemically induced , Neutropenia/chemically induced , Adult , Antibiotics, Antineoplastic/therapeutic use , Cytarabine/therapeutic use , Female , Humans , Idarubicin/therapeutic use , Induction Chemotherapy/adverse effects , Leukemia, Myeloid, Acute/drug therapy , Miliaria/pathology , Neutropenia/complicationsABSTRACT
Miliaria is a disorder of the eccrine sweat glands which occurs in conditions of increased heat and humidity. It can be associated with persistent febrile states as well as with certain drugs. We presented a 40 year-old female with myelodysplastic syndrome and progression to acute myelogenous leukemia who was admitted to the hospital for chemotherapy induction. The patient was treated with idarubicin and cytarabine. She became pancytopenic and developed neutropenic fever and was started on vancomycin and cefepime, but was persistently febrile with night sweats. Five days into her fevers, she developed diffuse, nonpruritic and fragile vesicles together with drenching nightsweats. The patient's exanthem was diagnosed as Miliaria crystallina, most probably induced by neutropenic fever and idarubucin exposure.
Miliária é uma desordem das glândulas sudoríparas écrinas, que ocorre em condições de aumento de calor e umidade. Miliária pode ser associada com estados febris persistentes bem como com certos medicamentos. Apresentamos o caso de uma mulher de 40 anos com síndrome mielodisplásica e progressão para leucemia mielóide aguda que foi admitida no hospital para quimioterapia de indução. A paciente foi tratada com idarrubicina e citarabina. Ela se tornou pancitopênica e desenvolveu neutropenia febril. Iniciou tratamento com vancomicina e cefepime, mas a febre com sudorese noturna continou. Cinco dias depois a paciente desenvolveu vesículas difusas, não pruríticas e frágeis juntamente com a persistência de sudorese noturna. O exantema do paciente foi diagnosticado como Miliária cristalina, provavelmente induzida por neutropenia febril e exposição a idarubucin.