ABSTRACT
INTRODUCCIÓN: En las últimas décadas, se ha incrementado la prevalencia de infecciones por bacilos gramnegativos resistentes a carbapenémicos. OBJETIVO: Determinar los tipos y la frecuencia de las distintas carbapenemasas en aislados de Klebsiella spp. y Pseudomonas aeruginosa, en seis hospitales de alta complejidad de Bogotá-Colombia. MÉTODOS: Estudio observacional descriptivo en seis hospitales de la ciudad de Bogotá, en el período de enero de 2017 a agosto de 2018. Se realizaron RPC para genes de KPC, GES, VIM, NDM, IMP y OXA-48 en cepas de Klebsiella spp y P aeruginosa resistentes a carbapenémicos. RESULTADOS: 52 aislados de P aeruginosa amplificaron para una carbapenemasa, de los cuales 39 (75%) fueron positivos para KPC, 11 (21%) para VIM y 2 co-producciones de KPC y VIM. En cuanto a Klebsiella spp., 165 cepas amplificaron al menos para una carbapenemasa, 98% expresaron KPC y 4 aislados tuvieron co-producciones de metalo-beta-lactamasas y KPC. DISCUSIÓN: Este estudio aporta información valiosa, como el incremento de producción de KPC en P. aeruginosa y la co-producción de KPC y metalo-beta-lactamasas, locual tiene una implicancia tanto en la selección del tratamiento, las medidas de aislamiento de contacto y el pronóstico de los pacientes.
BACKGROUND: In the last decades, the prevalence of infections by carbapenem resistant gram-negative bacilli has been increased. OBJECTIVE: To determine types and frequency of the different carbapenemases in Klebsiella spp. and Pseudomonas aeruginosa, in six hospitals in Bogotá-Colombia. METHODS: Descriptive and observational study, in six hospitals in the city of Bogotá, in the period ftom January 2017 to August 2018. PCR were performed for KPC, GES, VIM, NDM, IMP and OXA-48 genes, in carbapenem resistant Klebsiella spp. and P aeruginosa. RESULTS: 52 P aeruginosa isolates amplified a carbapenemase gene, of which 39 (75%) were positive for KPC, 11 (21%) for VIM and two co-productions of KPC and VIM. Regarding Klebsiella spp. 165 strains amplified at least one carbapenemase gene, 98% expressed KPC and four isolates had co-productions of metallo-P-lactamases and KPC. DISCUSSION: This study provides valuable information, such as the increased production of KPC in P. aeruginosa información valiosa, como el incremento de producción de KPC en P. aeruginosa and the co-production of KPC plus metallobetalactamases, which has an implication both in treatment selection, isolation precautions and patient prognosisy.
Subject(s)
Humans , Pseudomonas aeruginosa/genetics , Klebsiella , Bacterial Proteins/genetics , beta-Lactamases/genetics , Microbial Sensitivity Tests , Carbapenems/pharmacology , Colombia/epidemiology , Hospitals , Anti-Bacterial Agents/pharmacologyABSTRACT
BACKGROUND: In the last decades, the prevalence of infections by carbapenem resistant gram-negative bacilli has been increased. OBJECTIVE: To determine types and frequency of the different carbapenemases in Klebsiella spp. and Pseudomonas aeruginosa, in six hospitals in Bogotá-Colombia. METHODS: Descriptive and observational study, in six hospitals in the city of Bogotá, in the period ftom January 2017 to August 2018. PCR were performed for KPC, GES, VIM, NDM, IMP and OXA-48 genes, in carbapenem resistant Klebsiella spp. and P aeruginosa. RESULTS: 52 P aeruginosa isolates amplified a carbapenemase gene, of which 39 (75%) were positive for KPC, 11 (21%) for VIM and two co-productions of KPC and VIM. Regarding Klebsiella spp. 165 strains amplified at least one carbapenemase gene, 98% expressed KPC and four isolates had co-productions of metallo-P-lactamases and KPC. DISCUSSION: This study provides valuable information, such as the increased production of KPC in P. aeruginosa información valiosa, como el incremento de producción de KPC en P. aeruginosa and the co-production of KPC plus metallobetalactamases, which has an implication both in treatment selection, isolation precautions and patient prognosisy.
Subject(s)
Klebsiella , Pseudomonas aeruginosa , Anti-Bacterial Agents/pharmacology , Bacterial Proteins/genetics , Carbapenems/pharmacology , Colombia/epidemiology , Hospitals , Humans , Microbial Sensitivity Tests , Pseudomonas aeruginosa/genetics , beta-Lactamases/geneticsABSTRACT
Chile vive un envejecimiento acelerado, con expectativas de vida en aumento. Por otra parte, la tendencia a operar adultos mayores ha sido mayor que la esperada sólo por el envejecimiento de la población. Sin embargo, las complicaciones perioperatorias son más frecuentes en los ancianos. Entre otras razones destaca su mayor comorbilidad y el fenómeno de homeoestenosis. Todo esto determina que el paciente anciano requiera evaluaciones y cuidados especiales en el peri-operatorio. Esta revisión explica y discute el rol del Médico Geriatra y de la Evaluación Geriátrica Integralen reducir la morbi-mortalidad peri-quirúrgica del adulto mayor, especialmente del mayor de 80 años; resaltando los componentes de comorbilidad, medicamentos, funcionalidad y exámenes complementarios. También se discuten las principales medidas a considerar en el postoperatorio.
Chile is experiencing a process of accelerated aging with increasing in life expectancies. On the other hand, the tendency to operate elderly patients has been greater than that just explained by that of the aging population. Nevertheless, peri-operative complications are more common for the elderly than for the younger patient. Among other reasons, they have more comorbidities and the homeoestenosis phenomenon. All this explains why the elderly patient needs special care and evaluation in the peri-operative period. This review discuses and explains the importance of the Comprehensive Geriatric Assessment and the Geriatrician in reducing morbidity and mortality in the elderly patient, especialy over 80 years of age; emphasizing comorbidity, medications, functionality and lab testing. We also discuss the principal measures that must be considered on the postoperative period.
Subject(s)
Humans , Aged, 80 and over , Geriatric Assessment , Surgical Procedures, Operative , Perioperative Period , Postoperative Care , Risk FactorsABSTRACT
Streptococcus pneumoniae and Staphylococcus aureus cause significant morbidity and mortality worldwide. We investigated both the colonization and co-colonization characteristics for these pathogens among 250 healthy children from 2 to 5 years of age in Merida, Venezuela, in 2007. The prevalence of S. pneumoniae colonization, S. aureus colonization, and S. pneumoniae-S. aureus co-colonization was 28%, 56%, and 16%, respectively. Pneumococcal serotypes 6B (14%), 19F (12%), 23F (12%), 15 (9%), 6A (8%), 11 (8%), 23A (6%), and 34 (6%) were the most prevalent. Non-respiratory atopy was a risk factor for S. aureus colonization (p = 0.017). Vaccine serotypes were negatively associated with preceding respiratory infection (p = 0.02) and with S. aureus colonization (p = 0.03). We observed a high prevalence of pneumococcal resistance against trimethoprim-sulfamethoxazole (40%), erythromycin (38%), and penicillin (14%). Semi-quantitative measurement of pneumococcal colonization density showed that children with young siblings and low socioeconomic status were more densely colonized (p = 0.02 and p = 0.02, respectively). In contrast, trimethoprim-sulfamethoxazole- and multidrug-resistant-pneumococci colonized children sparsely (p = 0.03 and p = 0.01, respectively). Our data form an important basis to monitor the future impact of pneumococcal vaccination on bacterial colonization, as well as to recommend a rationalized and restrictive antimicrobial use in our community.
Subject(s)
Carrier State/epidemiology , Pneumococcal Infections/epidemiology , Staphylococcal Infections/epidemiology , Staphylococcus aureus/isolation & purification , Streptococcus pneumoniae/isolation & purification , Anti-Bacterial Agents/pharmacology , Bacterial Typing Techniques , Child, Preschool , Drug Resistance, Bacterial , Family Health , Female , Humans , Male , Microbial Sensitivity Tests , Prevalence , Risk Factors , Serotyping , Socioeconomic Factors , Venezuela/epidemiologyABSTRACT
Background: Stress caused by the high physical, intellectual and emotional demands imposed to medical students, renders them specially susceptible to the development of mental disorders. Aim: To assess the prevalence of risk for mental disorders among undergraduate students at the Medical School of the Catholic University of Chile. Material and methods : The Twelve Item General Health Questionnaire (GHQ 12) was voluntarily answered by medical students from the first to the fifth year. Results: Sixty eight percent of the total population (305 students) answered the questionnaire. Forty one percent of students were at risk, defined as scoring five or more points in the GHQ 12. The average score was 3.9ñ2.2. First year students had a higher score than fourth year students (4.6ñ2.2 and 3.4ñ2.1 points respectively, p <0.05). No gender differences were observed. Conclusions : Our results are similar to those of other publications concerning psychiatric risk among medical students
Subject(s)
Humans , Male , Female , Adolescent , Adult , Students, Medical/statistics & numerical data , Mental Disorders/epidemiology , Risk Factors , Stress, Psychological/complications , Psychological Tests/statistics & numerical dataABSTRACT
Background: Patients with chronic obstructive pulmonary disease have an increased inspiratory work, since they must overcome high loads due to increased airway resistance. Aim: To determine if the reduction in the metabolic cost of exercise observed in patients with chronic obstructive pulmonary disease (COPD) after inspiratory muscle training, was due to a reduction in the oxygen cost of breathing. Patients and methods: Nine patients with COPD (FEV1 39 ñ 13 percent) subjected to inspiratory muscle training, using a training load of 30 percent of maximal inspiratory pressure, during 10 weeks; 5 patients with COPD (FEV1 44 ñ 18 percent) not subjected to training, and 7 healthy controls (FEV1 110 ñ 10 percent) were studied. The cost of breathing was calculated as the difference in VO2 measured at rest and after breathing a gas mixture containing air and 5 percent CO2. Exercise VO2 was measured at submaximal exercise. Results: Oxygen cost of breathing was increased in patients with COPD and it was inversely correlated with FEV1 (r= -0.86 p<0.001). Inspiratory muscle training increased maximal inspiratory pressure and decreased exercise VO2. Oxygen cost of breathing increased in six and decreased in three trained patients. Changes in this parameter after training did not correlate with the reduction in exercise VO2 or the increment in maximal inspiratory pressure. Conclusions: The reduction in exercise VO2 after inspiratory muscle training is not due to a reduction in the oxygen cost of breathing
Subject(s)
Humans , Middle Aged , Breathing Exercises , Lung Diseases, Obstructive/rehabilitation , Basal Metabolism , Inspiratory Capacity/physiology , Oxygen Consumption/physiology , Respiratory Muscles/physiopathology , Pulmonary Ventilation/physiologyABSTRACT
Se estudio un caso de mononucleosis infecciosa (MI) desde el punto de vista clinico e inmunologico en una mujer de 23 anos con antecedentes de prostitucion, quien presento manifestaciones neurologicas como papiledema bilateral, cuadro meningeo, signo de Babinski y Clonus bilateral. Estas manifestaciones fueron asociadas con infeccion por el virus de Epstein Barr (VEB) diagnosticado por el hallazgo de titulos crecientes de anticuerpos acompanados por alteraciones en la respuesta inmune. Es el primer caso de este tipo de asociacion que se informa en la literatura local