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Genomic islands 1 and 2 carry multiple antibiotic resistance genes in Pseudomonas aeruginosa ST235, ST253, ST111 and ST175 and are globally dispersed.

Roy Chowdhury, Piklu; Scott, Martin J; Djordjevic, Steven P.

J Antimicrob Chemother ; 72(2): 620-622, 2017 02.

Article in English | MEDLINE | ID: mdl-27999026

Subject(s)

Drug Resistance, Multiple, Bacterial/genetics , Genomic Islands , Pseudomonas aeruginosa/genetics , Anti-Bacterial Agents/pharmacology , Asia/epidemiology , Computational Biology/methods , Europe/epidemiology , Humans , Pseudomonas Infections/epidemiology , Pseudomonas Infections/microbiology , Pseudomonas aeruginosa/drug effects , South America/epidemiology , United States/epidemiology

Recovery of a functional class 2 integron from an Escherichia coli strain mediating a urinary tract infection.

Márquez, Carolina; Labbate, Maurizio; Ingold, Ana J; Roy Chowdhury, Piklu; Ramírez, Maria S; Centrón, Daniela; Borthagaray, Graciela; Stokes, H W.

Antimicrob Agents Chemother ; 52(11): 4153-4, 2008 Nov.

Article in English | MEDLINE | ID: mdl-18794381

ABSTRACT

A class 2 integron was found in an Escherichia coli isolate mediating a urinary tract infection. Unlike other class 2 integrons from pathogens, the encoded IntI2 protein was functional. The integron possessed a dfrA14 cassette, and a second novel cassette in which a lipoprotein signal peptidase gene is predicted.

Subject(s)

Escherichia coli Infections/microbiology , Escherichia coli Proteins/genetics , Escherichia coli/genetics , Escherichia coli/pathogenicity , Integrases/genetics , Integrons , Urinary Tract Infections/microbiology , Drug Resistance, Multiple, Bacterial/genetics , Escherichia coli/enzymology , Escherichia coli/isolation & purification , Genes, Bacterial , Humans , Molecular Sequence Data , Plasmids/genetics , Recombination, Genetic

Subject(s)

ABSTRACT

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