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J Bacteriol ; 189(13): 4964-8, 2007 Jul.
Article in English | MEDLINE | ID: mdl-17468254

ABSTRACT

The genome of Stenotrophomonas maltophilia encodes a cell-cell signaling system that is highly related to the diffusible signal factor (DSF)-dependent system of the phytopathogen Xanthomonas campestris. Here we show that in S. maltophilia, DSF signaling controls factors contributing to the virulence and antibiotic resistance of this important nosocomial pathogen.


Subject(s)
Bacterial Proteins/genetics , Signal Transduction/genetics , Stenotrophomonas maltophilia/genetics , Anti-Bacterial Agents/pharmacology , Bacterial Proteins/metabolism , Bacterial Proteins/physiology , Cross Infection/microbiology , Drug Resistance, Bacterial/genetics , Gene Expression Regulation, Bacterial , Genes, Bacterial , Humans , Metals, Heavy/pharmacology , Multigene Family , Mutation , Signal Transduction/physiology , Stenotrophomonas maltophilia/drug effects , Stenotrophomonas maltophilia/pathogenicity , Virulence/genetics , Xanthomonas campestris/genetics
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