ABSTRACT
Ten megaspore species isolated from Moscow Basin lignites of Lower Carboniferous (Viséan) age have been studied by scanning and transmission electron microscopy (SEM and TEM). These species belong to seven megaspore genera: Lagenicula, Sublagenicula, Crassilagenicula, Setosisporites, Zonalesporites, Caudatosporites, and Cystosporites. Megaspores of the genus Caudatosporites have only been described previously from the Duckmantian (Westphalian B); a new species is duly erected. The ultrastructure of megaspore walls from the genera Crassilagenicula and Zonalesporites has not been previously described. This study also places them in context with other contemporaneous megaspores. The study shows that during the Viséan, in the Moscow Basin, megaspores expressed a similar wall ultrastructure despite large differences in external appearance. The genus Crassilagenicula may represent a group of megaspores from plants that had evolved from those bearing gulate megaspores here typified by Lagenicula acuminata, Setosisporites brevispinosus, and Sublagenicula hirsutoida. Zonalesporites brasserti also appears to show affinities to this group, and may be representative of a plant species in a transitional state between the Lagenicula bearing lycopsids and those more isoetalean in nature.
ABSTRACT
OBJECTIVE: To evaluate the possible association between primary hyperparathyroidism and malignant neoplasms. DESIGN: An historical cohort study. SETTING: The only Regional General Hospital of the Province of Udine, Italy (population = 500.000). PARTICIPANTS: All the 101 patients with surgically treated parathyroid adenomas. MAIN OUTCOME MEASURE: The incidence rate of malignant tumor was calculated for this cohort based on the number of incidence cases and the person-years at risk. Standardized morbidity rate ratios (SMR) were calculated to infer the cancer relative risk of the study cohort as compared with the general population. RESULTS: A total of 13 cases of malignant neoplasms were ascertained among cohort members. The overall number of observed cases of malignancy did not exceed the number of expected cases (SMR = 1.0). However, strong and statistically significant direct associations were found with bladder cancer (SMR = 5.1) and polycythemia vera (SMR = 62.5). CONCLUSIONS: Due to the magnitude of the associations between parathyroid and bladder cancer and polycythemia vera, it is unlikely that they might be explained completely by bias or chance. Rather, biologically plausible explanations were identified. Particularly, non-paraneoplastic hypercalcemia due to primary hyperparathyroidism may increase the risk of these malignancies.
