Synthesis of novel liquid phase exfoliation of chitosan/Bi2Se3 hybrid nanocomposites for in-vitro wound healing.

Numerous studies have recently established the potential of chitosan (Chi) to enhance wound healing. Chi is a carbohydrate biopolymer that is biocompatible, low-cost, toxic-free, and has excellent antibacterial properties. In this study, we synthesized Chi/Bi2Se3 hybrid nanocomposites (NCs) using a liquid exfoliation approach. The physicochemical characterization of the hybrid NCs was investigated using X-ray diffraction, Fourier transforms infrared, Thermogravimetric, Scanning electron microscope, and Transmission electron microscope. The antibacterial ability has been investigated versus two pathogens, S. aureus and E. coli. In comparison to bare materials, the hybrid NCs demonstrated better antibacterial activity against both bacterial strains. As a result, the electrostatic attraction of positively charged Chi can easily attract the negatively charged surface of the bacteria cell membrane and NCs generate reactive oxygen species (ROS). This ROS can attack bacteria's intracellular components and eventually kill bacteria. The biocompatibility of the Chi/Bi2Se3 NCs was evaluated against L929 mice fibroblast cells, and there was no evident cytotoxicity. Furthermore, an in-vitro wound scratch test was carried out on L929 mouse fibroblast cells and the Chi/Bi2Se3 hybrid NCs promote wound healing and cell proliferation. These findings suggest that the Chi/Bi2Se3 hybrid NCs as a promising future material for bacteria-infected in-vivo wound healing.

Fabrication of eco-friendly chitosan functionalized few-layered WS2 nanocomposite implanted with ruthenium nanoparticles for in vitro antibacterial and anticancer activity: Synthesis, characterization, and pharmaceutical applications.

The abundance of two-dimensional (2D) components has provided them with a broad material platform for building nano and atomic-level applications. So, 2D nanomaterials are unique because of their physicochemical properties. Over many years, graphene is a conventional 2D layered element that has significant attention in the scientific community. In recent years numerous new 2D nanomaterials other than graphene have been reported. The study of 2D nanomaterials is also in its infant stages, with the majority of research focusing on the explanation of special material properties, but very few articles are focusing on the biological applications of 2D nanomaterials. As a result, we focused on the transition metal dichalcogenides (TMDCs) such as MoS2 and WS2, which were emerging and exciting groups of elements with display great opportunities in several fields, such as cancer nanomedicine. Herein, we synthesized biologically active CS/WS2/Ru composite by liquid exfoliation approach. The CS/WS2/Ru composites exhibit significant antibacterial action towards (S. aureus, and E. coli) bacteria. Also, the composite suggests synergetic anticancer action against MCF-7 cancer cells. These reports are possible to explore the innovative aspects of biological outcomes in carcinological applications.