1.
Bioorg Med Chem Lett
; 18(7): 2509-12, 2008 Apr 01.
Article
in English
| MEDLINE
| ID: mdl-18331794
ABSTRACT
A novel series of barbituric acid derivatives were identified as selective inhibitors of alpha4beta7 MAdCAM (mucosal addressin cell adhesion molecule-1) interactions via a high throughput screening exercise. These inhibitors were optimized to submicromolar potencies in whole cell adhesion assays, retaining their selectivity over alpha4beta1 VCAM.