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BACKGROUND: Prognosis of Chronic Chagasic Cardiomyopathy (CCC) patients depends on functional and clinical factors. Bradyarrhythmia requiring pacemaker is a common complication. Prognosis of these patients is poorly studied, and mortality risk factors are unknown. We aimed to identify predictors of death and to define a risk score for mortality in a large cohort of CCC patients with pacemaker. METHODS: It was an observational, unicentric and prospective study. The endpoint was all-cause mortality. Cox regression was used to identify predictors of death and to define a risk score. Bootstrapping method was used to internal score validation. RESULTS: We included 555 patients and after a mean follow-up of 3.7±1.5 years, 100 (18%) deaths occurred. Predictors of death were: right ventricular dysfunction (HR [hazard ratio] 2.24; 95%CI 1.41-3.53; P = 0.001); heart failure class III or IV (HR 2.16; 95% confidence interval [95%CI] 1.16-4.00; P = 0.014); renal disease (HR 2.14; 95%CI 1.24-3.68; P = 0.006); left ventricular end-systolic diameter > 44mm (HR 1.97; 95%CI 1.26-3.05; P = 0.003); atrial fibrillation (HR 1.94; 95%CI 1.25-2.99; P = 0.003) and cardiomegaly on X-ray (HR 1.87; 95%CI 1.10-3.17; P = 0.020). The score identified patients with: low (0-20 points), intermediate (21-30 points) and high risk (>31points). The optimism-corrected C-statistic of the predictive model was 0.751 (95% CI 0.696-0.806). Internal validation with bootstrapping revealed a calibration slope of 0.946 (95% CI 0.920-0.961), reflecting a small degree of over-optimism and C-statistic of 0.746 (95% CI 0.692-0.785). CONCLUSIONS: This study identified predictors of mortality in CCC patients with pacemaker defining a simple, validated and specific risk score.
Subject(s)
Chagas Cardiomyopathy , Pacemaker, Artificial , Humans , Male , Female , Chagas Cardiomyopathy/mortality , Middle Aged , Prospective Studies , Aged , Risk Factors , Prognosis , Risk Assessment , AdultABSTRACT
BACKGROUND: It is estimated that atrial fibrillation (AF) affects approximately 1.5 million people in Brazil; however, epidemiological data are limited. We sought to evaluate the characteristics, treatment patterns, and clinical outcomes in patients with AF in Brazil by creating the first nationwide prospective registry. METHODS: RECALL was a multicenter, prospective registry that included and followed for 1 year 4,585 patients with AF at 89 sites across Brazil from April 2012 to August 2019. Patient characteristics, concomitant medication use, and clinical outcomes were analyzed using descriptive statistics and multivariable models. RESULTS: Of 4,585 patients enrolled, the median age was 70 (61, 78) years, 46% were women, and 53.8% had permanent AF. Only 4.4% of patients had a history of previous AF ablation and 25.2% had a previous cardioversion. The mean (SD) CHA2DS2-VASc score was 3.2 (1.6); median HAS-BLED score was 2 (2, 3). At baseline, 22% were not on anticoagulants. Of those taking anticoagulants, 62.6% were taking vitamin K antagonists and 37.4% were taking direct oral anticoagulants. The primary reasons for not using an oral anticoagulant were physician judgment (24.6%) and difficulty in controlling (14.7%) or performing (9.9%) INR. Mean (SD) TTR for the study period was 49.5% (27.5). During follow-up, the use of anticoagulants and INR in the therapeutic range increased to 87.1% and 59.1%, respectively. The rates/100 patient-years of death, hospitalization due to AF, AF ablation, cardioversion, stroke, systemic embolism, and major bleeding were 5.76 (5.12-6.47), 15.8 (14.6-17.0), 5.0 (4.4-5.7), 1.8 (1.4-2.2), 2.77 (2.32-3.32), 1.01 (0.75-1.36), and 2.21 (1.81-2.70). Older age, permanent AF, New York Heart Association class III/IV, chronic kidney disease, peripheral arterial disease, stroke, chronic obstructive pulmonary disease, and dementia were independently associated with increased mortality while the use of anticoagulant was associated with lower risk of death. CONCLUSIONS: RECALL represents the largest prospective registry of patients with AF in Latin America. Our findings highlight important gaps in treatment, which can inform clinical practice and guide future interventions to improve the care of these patients.
Subject(s)
Atrial Fibrillation , Stroke , Humans , Female , Aged , Male , Atrial Fibrillation/epidemiology , Atrial Fibrillation/therapy , Atrial Fibrillation/complications , Brazil/epidemiology , Risk Factors , Stroke/epidemiology , Stroke/etiology , Stroke/prevention & control , Anticoagulants , Hemorrhage/chemically induced , RegistriesABSTRACT
Resumo A comunicação, a despeito de ser considerada um aspecto primordial no exercício da prática médica, não ganhou tanta proeminência na literatura e formação médica quanto os aspectos tecnológicos e biomédicos. Em resposta a esse contexto, surgiram campos de conhecimento que se propõem a refletir e fortalecer aspectos da comunicação entre o médico e o paciente. No presente artigo, realizamos uma análise narrativa da literatura de três abordagens de comunicação em Saúde: Grupos Balint, Método Clínico Centrado na Pessoa e Medicina Baseada em Narrativa. Foram destacados aproximações e distanciamentos entre tais abordagens, com o reconhecimento da potência própria de cada uma delas nos diversos contextos da prática médica.
Resumen La comunicación, a pesar de considerarse un aspecto primordial en el ejercicio de la práctica médica, no obtuvo tanto destaque en la literatura y en la formación médica como el que tuvieron los aspectos tecnológicos y biomédicos. Como respuesta a ese contexto, surgieron campos de conocimiento cuya propuesta es reflejar y fortalecer aspectos de la comunicación entre el médico y el paciente. En este artículo, realizamos un análisis narrativo de la literatura de tres abordajes de comunicación en salud: Grupos Balint, Método Clínico Centrado en la Persona y Medicina Basada en la Narrativa. Se destacaron aproximaciones y distanciamientos entre tales abordajes, con el reconocimiento de la potencia propia de cada una de ellas en los diversos contextos de la práctica médica.
Abstract Communication, despite being considered a key aspect in medical practice, has not received the corresponding attention both on literature and medical training as has the technological and biomedical aspects. As a reaction to this context emerged fields of knowledge proposing to reflect and strengthen aspects of communication between the physician and the patient. In this article, we perform a narrative analysis of the literature of three of such approaches to communication in health: the Balint Groups, the Patient Centered Care and Narrative-Based Medicine. The study highlights the approximations and distances between these approaches, along with the recognition of the potency of each of them in the different contexts of medical practice.
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Resumo O objetivo deste artigo é apresentar as narrativas da Comunidade Ballroom de São Paulo, para situar como as práticas de prevenção combinada ao HIV se dão em pessoas negras LGBTQIAPN+, identificando como as estratégias se conformam, com que elementos e influências, ausências e restrições. Trata-se de uma pesquisa qualitativa no campo da Saúde Coletiva que utiliza entrevistas semiestruturadas com lideranças dessa comunidade para reconstruir as narrativas sobre HIV, abrindo um arquivo negro sobre prevenção. Tal perspectiva, alinhado ao trabalho de Saidiya Hartman pela perspectiva do pensamento negro radical, debruça-se sobre as histórias que não foram e ainda serão contadas: uma forma de imaginar radicalmente o futuro da negridade. Enquanto força analítica, o arquivo negro da prevenção tem a função de reparação, ampliando narrativas pela ótica racial, ocluindo uma história única da epidemia de HIV/Aids.
Abstract This article aims to present the narratives of the Ballroom Community in São Paulo to situate how combined HIV prevention practices are carried out in these people, identifying how the strategies conform, with what elements and influences, absences and restrictions. This is a qualitative research in the field of Collective Health that uses semi-structured interviews with Ballroom leaders to reconstruct narratives about HIV, opening a black archive on prevention. Such a perspective, in line with Saidiya Hartman's work from the perspective of radical black thought, focuses on the stories that have not been and will still be told: a way of radically imagining the future of blackness. As an analytical force, the black archive has the function of reparation, expanding narratives from a racial perspective, occluding a unique history of the HIV/Aids epidemic.
Subject(s)
Chagas Cardiomyopathy , Chagas Disease , Humans , Chagas Cardiomyopathy/therapy , Heart , Chronic DiseaseSubject(s)
Cardiology , Cardiovascular System , Humans , Brazil , Electrocardiography , Societies, MedicalABSTRACT
Introdução: A pandemia causada pelo coronavírus SARS-CoV-2 trouxe uma pressão descomunal sobre os sistemas de saúde, especialmente sobre a disponibilidade de leitos, equipamentos e recursos humanos das unidades de terapia intensiva (UTI), que mesmo antes desse cenário já apresentavam dificuldades, em especial na gestão de equipamentos. Embora se tenha passado mais de 10 anos do início da obrigatoriedade da gestão de tecnologias em serviços de saúde, a sua implementação na prática ainda é um desafio e um problema de saúde pública. Objetivo: Verificar a implantação do Plano de Gerenciamento de Tecnologias de equipamentos médico-assistenciais nas UTI de Goiânia, parte integrante da gestão de tecnologias. Método: Como base utilizou-se dados secundários coletados em um guia elaborado pela Vigilância Sanitária, aplicado em dois momentos durante as inspeções em UTI. Os dados foram analisados de forma comparativa e os resultados apresentados por meio de frequência absoluta, relativa e de análise estatística. Resultados: Os níveis de implantação do Plano de Gerenciamento de Tecnologias encontrados foram de 25,8% e 40,9% na 1ª e 2ª inspeção, respectivamente. Conclusões: Investimentos em treinamento e em programa de educação permanente podem levar a uma melhoria na implantação do plano e, consequentemente, a um avanço na qualidade do serviço oferecido ao usuário. Considerando que a Vigilância Sanitária é um importante catalisador dessa mudança, este estudo traz dados importantes para os gestores priorizarem ações e formularem políticas públicas na Saúde Coletiva que servirão para melhorar a segurança dos pacientes e, por consequência, ajudar no enfrentamento da COVID-19.
Introduction: The pandemic caused by the SARS-CoV-2 coronavirus has brought a huge pressure on health systems, in particular the availability of beds, equipment and human resources in Intensive Care Units (ICU), which even before this scenario already had difficulties, especially in equipment management. Although more than 10 years have passed since the beginning of mandatory technology management in health services, its implementation in practice is still a challenge and a public health problem. Objective: To verify the implementation of the Medical Equipment Technology Management Plan in the ICUs of Goiânia, Goiás, an integral part of technology management. Method: As a basis, secondary data collected in a Guide prepared by the Sanitary Surveillance was used, applied in two moments during inspections in the ICU. The data were analyzed comparatively and the results presented through absolute and relative frequency and statistical analysis. Results: The levels of implementation of the Technology Management Plan found were 25.8% and 40.9% in the 1st and 2nd inspection, respectively. Conclusions: Investments in training and in a permanent education program can be a direction to improve the implementation of the plan and, consequently, an advance in the quality of the service offered to the user. Considering that Health Surveillance is an important catalyst for this change, this study provides important data for managers to prioritize actions and formulate public policies in Public Health that will serve to improve patient safety and, consequently, help in coping with COVID-19.
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ABSTRACT BACKGROUND: Lung transplantation (LTx) has been discussed as an option for treating irreversible lung fibrosis post-coronavirus disease 2019 (COVID-19), in selected cases. OBJECTIVES: To report on the initial experience and management of end-stage lung disease due to COVID-19 at a national center reference in Brazil. DESIGN AND SETTING: Cohort study conducted at a national reference center for lung transplantation. METHODS: Medical charts were reviewed regarding patients' demographics and pre-COVID-19 characteristics, post-LTx due to COVID-19. RESULTS: Between March 2020 and September 2021, there were 33 cases of LTx. During this period, we evaluated 11 cases of severe COVID-19-related acute respiratory distress syndrome (ARDS) that were potentially candidates for LTx. Among these, LTx was only indicated for three patients (9.1%). All of these patients were on venovenous extracorporeal membrane oxygenation (ECMO), and the procedure that they underwent was central venoarterial ECMO. All three patients were still alive after the first 30 postoperative days. However, patient #1 and patient #2 subsequently died due to fungal sepsis on the 47th and 52nd postoperative days, respectively. Patient #3 was discharged on the 30th postoperative day. CONCLUSIONS: LTx is feasible among these complex patients. Survival over the first 30 days was 100%, and this favors surgical feasibility. Nonetheless, these were critically ill patients.
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BACKGROUND: We aimed to identify, among Chronic Chagas Cardiomyopathy (CCC) patients with left ventricular dysfunction (LVD) and non-left bundle branch block (non-LBBB), subgroups with different functional and mechanical patterns of global longitudinal strain (GLS) and intraventricular dyssynchrony (IVD) at rest and after exercise stress test, and reclassify them using a new echocardiographic approach. METHODOLOGY: In this single-center cross-sectional study, 40 patients with CCC, left ventricular ejection fraction (LVEF) ≤ 35% and non-LBBB underwent rest echocardiography and then treadmill exercise stress echocardiography with GLS and IVD analysis. The sample was divided into four groups, based on GLS and IVD significant variation between rest and exercise: GLS + IVD+ (9 patients); GLS + IVD- (9 patients); GLS-IVD+ (10 patients); GLS-IVD- (10 patients). RESULTS: At rest, median LVEF was 28% (21.3%-33%) and GLS (-7% (-5%/-9.3%), were not different among groups. The average response of GLS was an increase of 0.74% over rest values, and the average response of IVD was a decrease of 6.9 ms. Group GLS-IVD+ presented more dyssynchrony at rest (p = 0.01). Left atrial (LA) volume (higher in GLS-IVD-) (p = 0.022) and TAPSE (higher in GLS + IVD+) (p = 0.015) were also different among groups at baseline. Of the 40 patients evaluated, 27 (67.5%) had very severe LVD (GLS < -8%). In addition, among these patients, 11 patients had contractile reserve after undergoing stress echocardiography. CONCLUSIONS: In patients with CCC, severe LVD and non-LBBB, the evaluation of GLS and IVD between rest and exercise was able to reclassify myocardial function and to identify subgroups with contractile reserve and significant dyssynchronopathy.
Subject(s)
Chagas Cardiomyopathy , Ventricular Dysfunction, Left , Chagas Cardiomyopathy/diagnostic imaging , Cross-Sectional Studies , Echocardiography , Humans , Stroke Volume , Ventricular Dysfunction, Left/diagnostic imaging , Ventricular Dysfunction, Left/epidemiology , Ventricular Function, LeftABSTRACT
BACKGROUND: Lung transplantation (LTx) has been discussed as an option for treating irreversible lung fibrosis post-coronavirus disease 2019 (COVID-19), in selected cases. OBJECTIVES: To report on the initial experience and management of end-stage lung disease due to COVID-19 at a national center reference in Brazil. DESIGN AND SETTING: Cohort study conducted at a national reference center for lung transplantation. METHODS: Medical charts were reviewed regarding patients' demographics and pre-COVID-19 characteristics, post-LTx due to COVID-19. RESULTS: Between March 2020 and September 2021, there were 33 cases of LTx. During this period, we evaluated 11 cases of severe COVID-19-related acute respiratory distress syndrome (ARDS) that were potentially candidates for LTx. Among these, LTx was only indicated for three patients (9.1%). All of these patients were on venovenous extracorporeal membrane oxygenation (ECMO), and the procedure that they underwent was central venoarterial ECMO. All three patients were still alive after the first 30 postoperative days. However, patient #1 and patient #2 subsequently died due to fungal sepsis on the 47th and 52nd postoperative days, respectively. Patient #3 was discharged on the 30th postoperative day. CONCLUSIONS: LTx is feasible among these complex patients. Survival over the first 30 days was 100%, and this favors surgical feasibility. Nonetheless, these were critically ill patients.
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As barragens de rejeito de minério de ferro fazem parte do processo de mineração no Brasil. Trata-se de uma técnica antiga envolvendo diversas tecnologias para torná-la mais segura. A constante vigília e cuidado sobre essas estruturas tornaram-se uma rotina frequente das mineradoras para evitar possíveis rupturas dessas barragens. Após o rompimento da barragem de rejeitos de minério em Brumadinho-MG e Mariana-MG muitos discursos com elementos metafóricos acerca da sustentabilidade e a prática de uso de barragens de rejeitos foram sustentados por uma intencionalidade discursiva voltada para a crítica social. O objetivo deste estudo é identificar e analisar o uso de metáforas conceptuais presentes como elementos multimodais na argumentação textual, numa perspectiva sociocognitiva e interacional da linguagem. Para isso, adota-se uma pesquisa expo-facto. O viés teórico da intencionalidade discursiva na linha de Searle; o caráter de modelos mentais, representações sociais e conhecimento sociocultural tal com prevê Van Dijk, a visão sociosemiótica de Geeraerts para compreender como argumentação por meio do campo imagético das charges é construída e sustentada socialmente e o dialogismo na perspectiva de Meyer a partir da argumentação. Nessa perspectiva sociocognitiva e interacional, o texto é pensado como uma construção linguístico-discursiva na qual a intencionalidade está relacionada com os modelos mentais resultantes de representações construídas a partir da experiencia do sujeito em sociedade e das práticas interacionais. Nesse contexto, o texto contempla uma gama de operações cognitivas interligadas como direciona Marscuschi. Constitui-se um corpus de charges publicadas na mídia brasileira, orientadas para a temática do rompimento de barragens de rejeitos de minério de ferro para a análise do aparecimento de metáforas conceptuais. Conclui-se que as metáforas se constituem recursos multimodais na orientação argumentativa e revelam metáforas do medo e da lama envolvendo um discurso do horror sobre a tragédia das cidades de Brumadinho e Mariana.
Iron ore tailings dams are part of the mining process in Brazil. It is an old technique involving several technologies to make it more secure. Constant vigilance and care about these structures have become a frequent routine for mining companies to avoid possible failures of these dams. After the collapse of the ore tailings dam in Brumadinho (MG) and Mariana (MG) cities, many discourses with metaphorical elements about sustainability and the practice of using tailings dams were supported by a discursive intentionality focused on social criticism. The aim of this study is to identify and analyze the use of conceptual metaphors present as multimodal elements in textual argumentation, in a sociocognitive and interactional perspective of language. For this, it is adopted from expo-facto research. The theoretical bias of discursive intentionality along the lines of Searle; the character of mental models, social representations,and sociocultural knowledge as predicted by Van Dijk, the sociosemiotic vision of Geeraerts (2016) to understand how argumentation through the imagery field of cartoons is constructed and socially supported and dialogism in perspective of Meyer from the argumentation. In this sociocognitive and interactional perspective, the text is thought of as a linguistic-discursive construction in which intentionality is related to mental models resulting from representations built from the subject's experience in society and interactional practices. In this context, the text contemplates a range of interconnected cognitive operations as directed by Marscuschi. A corpus of cartoons published in the Brazilian media is constituted, oriented to the theme of breaking up iron ore tailings dams for the analysis of the appearance of conceptual metaphors. It is concluded that metaphors are multimodal resources in the argumentative orientation and reveal metaphors offear and mud involving a horror speech about the tragedy of the cities of Brumadinho and Mariana.
Subject(s)
Humans , Man-Made Disasters , Cognition , Metaphor , Behavior Control , Mass Media , Mining , Audiovisual Aids , Brazil , ComprehensionABSTRACT
INTRODUÇÃO: Resultados favoráveis foram relatados com estimulação direta do sistema de excito-condutor cardíaco, o que tem motivado a inclusão desta técnica em recomendações e diretrizes atuais. Entretanto, não há dados disponíveis dessa prática no Brasil. OBJETIVOS: Descrever as características demográficas, eletrocardiográficas e ecocardiográficas assim como os achados intra e peri-operatórios dos pacientes submetidos a estimulação fisiológica no Brasil. MÉTODOS: Trata-se de um registro multicêntrico realizado em 15 centros no Brasil. A técnica cirúrgica utilizada seguiu a rotina dos centros participantes. RESULTADOS: 180 pacientes (64,9% homens, 74,8±12,5 anos) foram incluídos na análise entre maio e setembro de 2021. Características clínicas: 82,7% eram hipertensos, 33,5% diabéticos, 51,9% tinham antecedente de sincope, 23,2% DAC e 0,7% doença de Chagas; 76,7% apresentavam-se em CF-NYHA I ou II. A cardiopatia subjacente e o motivo do implante estão ilustrados na figura 1. Em 13,5% dos pacientes, o CDI foi concomitantemente indicado. Quanto aos achados eletrocardiográficos, 89,2% dos pacientes apresentavam-se em ritmo sinusal e 10,8% em FA/flutter atrial. O QRS basal médio era de 131±32ms; 28,1% dos pacientes apresentavam BRE e 31,4% BRD. A FEVE média foi de 54,14±16,66%. Todos os centros reportaram sucesso do implante. O tempo médio de fluoroscopia foi de 17,6±14,5min e a duração média do procedimento 81,8±43,8. Dispositivo bicameral foi predominante na maior parte dos casos (figura 2). Em 75,1% dos casos, o eletrodo ventricular foi posicionado no RE/septo profundo (LVAT médio 77,7±10,7ms, potencial de RE reportado em 25,7%) enquanto o feixe de His foi a posição escolhida em 24,9% dos casos. Em 6,6% dos pacientes procedeu-se HOT/LOT-CRT. A onda R média foi 9,8mV e o limiar de captura 1,17V x 1,0ms. A duração média do QRS final foi 107,46 ± 18,6ms. As taxas de complicações foram baixas (figura 3). CONCLUSÕES: O implante de marcapasso fisiológico é factível e seguro. As características dos pacientes incluídos nesse registro brasileiro, a preferência quanto ao tipo de estimulação (RE) e os resultados intra e pós operatórios precoces estão alinhados com as publicações internacionais mais recentes.
Subject(s)
Cardiac Pacing, Artificial , Guidelines as Topic , Heart Conduction SystemABSTRACT
OBJECTIVE: To understand the meanings attributed by Primary Health Care workers to the professional training process in Integrative and Complementary Practices. METHOD: Descriptive, exploratory study with a qualitative approach, carried out with 20 professionals from 14 health units in three municipalities in the Metropolitan Region of Goiânia, state of Goiás, Brazil. Data were collected through semi-structured interviews, transcribed and analyzed using the thematic content analysis. RESULTS: Based on the analysis, the thematic category about training trajectories in Integrative and Complementary Practices emerged. It discusses that the training takes place through training provided by federal and municipal management or professional councils, via distance, semi-presential learning or in-person training. Furthermore, training courses are held at private educational institutions funded by the professionals themselves. Additionally, informal sources of information are used to obtain knowledge (internet, books and magazines). CONCLUSION: The results show, on the one hand, insufficient and diffuse training, with limited supply and quality and, on the other hand, the need to increase educational strategies to improve the training of health professionals aiming at providing different Integrative and Complementary Practices in the Primary Health Care.
O objetivo deste artigo é compreender os sentidos atribuídos por trabalhadores da Atenção Primária à Saúde ao processo de formação profissional nas Práticas Integrativas e Complementares. Estudo descritivo, exploratório, com abordagem qualitativa, com 20 profissionais, de 14 unidades de saúde de três municípios na Região Metropolitana de Goiânia. Os dados foram coletados com entrevistas semiestruturadas, transcritas e analisadas por meio da Análise de Conteúdo Temática. Da análise, emergiu a categoria temática sobre as trajetórias de formação nas Práticas Integrativas e Complementares. Nela discute-se que a formação se dá por capacitações proporcionadas pela gestão federal, municipal ou conselhos de categoria profissional, via educação à distância, semipresencial ou presencial. Além disso, são realizadas formações em instituições privadas de ensino custeadas pelos próprios profissionais. Também, fontes informais de informações são usadas para obtenção de conhecimento (internet, livros e revistas). Os resultados revelam, por um lado, a formação insuficiente e difusa, com limitação na oferta e na qualidade, por outro, a necessidade de ampliação de estratégias educacionais que melhorem a formação dos profissionais de saúde para a oferta das diferentes Práticas Integrativas e Complementares na Atenção Primária à Saúde.