Convex-probe endobronchial ultrasound for thyroid biopsy a new hybrid method.

Nowadays we use novel diagnostic equipment for lung cancer. Bronchoscopy was the tip of the arrow for diagnosis, however; ultrasound systems have brought a revolution. We have the radial-endobronchial ultrasound for peripheral lesions and the convex probe endobronchial ultrasound for central lesions. Ultrasound endoscopic systems can be used for the diagnosis of any lesion that can be approached from the airways. In the current manuscript we will present two methods for the biopsy of thyroid gland. The first method is using anesthisiological tools and the second tools from the ear, nose and throat department.

Inhaled Immunotherapy Administration for Lung Cancer; Efficient? Certainly Possible.

Lung cancer is still diagnosed at a late stage in most lung cancer patients. Regarding Non-small Cell lung cancer there are novel therapies such as; tyrosine kinase inhibitors and immunotherapy. Currently we have two immunotherapies that can be used either as first-line treatment or second line treatment; pembrolizumab and nivolumab. A third one is being investigated as a combination of immunotherapy; ipilimumab. Aerosol treatment has been investigated for many diseases not only for the lung, but also for systematic diseases. The design of cups was found the most significant factor in producing significant effects. The comparison of cups reveals the design J as the most capable of reducing the droplets at a minimum size of mass median aerodynamic diameter (MMAD) MMAD=1.99. Drug effect comes second in sequence (F=62.04) showing that nivolumab is the most drastic preparation at low particle sizes (1.89), two drugs share an intermediate particle diameter (pembrolizumab and ipilimumab). In total drugs demonstrate a decreasing droplet size: Ipilimumab>Pembrolizumab> Nivolumab.

Hamman's syndrome (spontaneous pneumomediastinum presenting as subcutaneous emphysema): A rare case of the emergency department and review of the literature.

Pneumomediastinum is a rare clinical entity that concerns the clinicians in the emergency department. We present a case of a patient with spontaneous pneumomediastinum (Hamman's syndrome) that presented to our hospital's emergency department with cervical subcutaneous emphysema. A conservative treatment with observation was performed. The patient after 24 hours of observation was discharged with a suggested follow-up.

Obstruction of the right stem bronchus due to ovarian local metastasis: a 5-year follow-up.

Currently interventional bronchoscopy is used for debulking, desobstruction and airway patency stabilization. The interventional techniques are being used for both benign and malignant cases. There are two types of stents that are currently being used, silicon and self-expandable metallic. The method of application and stent remains for the treating physician to choose. In the current case we will present a case of metastatic disease from ovarian cancer in the airway lumen and a long term follow-up.

Comparative study of 5 different membranes for guided bone regeneration of rabbit mandibular defects beyond critical size.

BACKGROUND: Although several studies have examined use of collagen membranes in guided bone regeneration (GBR), none has examined the use of human fascia temporalis as a bioabsorbable barrier. The majority of studies related to GBR have examined critical size defects. We sought to assess the human fascia temporalis and other well-documented membranes applied for GBR in mandibular osseous defects beyond critical size. MATERIAL/METHODS: Fifty adult male New Zealand white rabbits were used in this study. Five groups of 10 animals each were used: HFL (human fascia lata membrane), HP (human pericardium), HFT (human fascia temporalis), BP (bovine pericardium), and PTFE (expanded polytetrafluoroethylene). Animals were killed 10 weeks after membrane application. In each animal, 9-mm circular mandibular defects were created bilaterally. On 1 side of the jaw, the defect was covered with 1 of the test membranes; the defect on the other side served as a control. Harvested specimens were examined histologically. RESULTS: Membranes were significantly superior to the controls in all animals (P<0.001). Paired comparisons showed that groups HFL, HP, BP, and PTFE were significantly superior to HFT (P<0.05). Conversely, comparisons of HFL-HP, HFL-BP, HFL-PTFE, HP-BP, HP-PTFE, and BP-PTFE, showed no significant differences (P>0.05). CONCLUSIONS: According to our results, the fascia temporalis is not recommended for GBR techniques. The fascia lata, human pericardium, bovine pericardium, and e-PTFE advance bone regeneration and can be successfully used as GBR membranes for osseous defects beyond the critical size.