ABSTRACT
Aim: Antimicrobials are among the most widely prescribed therapeutic agents among paediatric population. Irrational use of these agents increases the risk of antimicrobial resistance. We described the prevalence and pattern of antimicrobial use among paediatric inpatients from 2017 to 2019. Subject and Method: The study was a repeated point prevalence survey over a 3-year period using the global point prevalence standardized tools among all paediatric inpatients. The prevalence of antimicrobial use, the prescription indicators and patterns of antimicrobial use were estimated. Result: Among 191 paediatric inpatients assessed, the 3-year period prevalence antimicrobial use was 85.9% (164/191) with prevalence of 80.6% in 2017, 94.6% in 2018, and 83.6% in 2019. Antimicrobial agents used ranged from one agent (20.1%) to five different agents (5.5%). Parenteral route (66.6%) was the preferred route of administration. The reason for the use of antimicrobial agents (92.6%) and the stop/review date (99.5%) were mostly well documented. Only 4.5% of the antimicrobial use were targeted. There were no antimicrobial guidelines or policy guiding the use of antimicrobial agents, except the national guideline on the treatment of malaria and tuberculosis. Ceftriaxone, a third generation cephalosporin was the most commonly used agent across the period under review. Community-acquired infection was the commonest indication for antimicrobial use. Conclusion: Our findings of high antimicrobial prevalence has raised the attention for the need to develop hospital-based antimicrobial guideline and antimicrobial stewardship program to protect the vulnerable children, their contacts and the environment from the impact of antimicrobial resistance.
ABSTRACT
Objectives: Evidence-based newborn care practice recommended by WHO reduces neonatal mortality and improves neonatal outcomes. This study assessed the knowledge, practice-associated factors and predictors of essential newborn care among post-natal mothers in two primary health care centres in Southeast Nigeria. Design: A cross-sectional total population study. Setting: Two primary health care centres in two local government areas in Southeast Nigeria. Participants: Post-natal mothers who attended immunisation clinics. Data collection: Quantitative data was collected over four weeks from 400 post-natal mothers. Chi-square test and logistic regression were carried out for associations and predictors, respectively. Analytical decisions were taken at p<0.05 and 95% confidence interval. Outcome measures: Knowledge, attitude, the practice of essential newborn care; predictors of practice. Findings: Mean age of participants was 28.68±5.4. The majority (78.9%) had been counselled on newborn care and 85.2% delivered in a formal health facility. The majority (77%) had good knowledge of essential newborn care and practices (61%). More than half (62.3%) reported support from health workers. Predictors of good practice were older age (AOR: 0.435; 95%CI: 0.212-0.893), being married (AOR: 8.095; 95%CI: 3.732-17.558), living in the urban area (AOR: 0.478; 0.291-0.784), and having good knowledge of newborn care (AOR: 0.239; CI: 0.139-0.411). Conclusions: Good practice was identified in the majority. Being married, older, living in urban areas and having good knowledge were predictors of good practice. Health facility delivery, continuous support by health workers and post-natal education to mothers in rural areas are recommended policy priorities. Funding: None declared.