Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters











Database
Language
Publication year range
1.
Ann Hepatol ; 15(6): 853-861, 2016.
Article in English | MEDLINE | ID: mdl-27740518

ABSTRACT

 Background and rationale. Nonalcoholic fatty liver disease (NAFLD) is the most common cause of pediatric liver disease in western countries. Its prevalence in Indian subcontinent is not well studied. MATERIAL AND METHODS: In a school based cross sectional study we have screened overweight and obese children in the age group of 11 to 15 years for NAFLD. Ultrasonography, elevated serum transaminases, fibroscan were used for defining NAFLD. Dietary habits, blood pressure, serum lipid profile, blood counts and insulin resistance were recorded. The relation of fibrosis 4 score, pediatric NAFLD fibrosis index, aspartate transaminases to platelet ratio index (APRI) with fibroscan was evaluated. RESULTS: Out of 616 students screened 198 were overweight and obese. Hundred students and their parents gave informed consent for the further evaluation. The prevalence of NAFLD was 62% in overweight and obese children. Fatty liver was found in 50 % students on ultrasonography, liver stiffness (≥ 6.1 Kilopascals) in 23% and raised alanine transaminase in 30%. Hypertension, dyslipidemia, diabetes mellitus and insulin resistance were seen in 6%, 18%, 2% and 66% students respectively. Systolic hypertension, serum triglyceride, aspartate transaminase, APRI was significantly higher in the NAFLD group. On binary logistic regression only systolic hypertension was an independent risk factor for NAFLD. CONCLUSION: In conclusion NAFLD is common in asymptomatic overweight and obese Indian children. Systolic hypertension is the only independent factor associated with NAFLD. Fibroscan has limited role for screening. We recommend screening for NAFLD in this high risk group with alanine transaminases and ultrasonography.


Subject(s)
Liver Cirrhosis/epidemiology , Non-alcoholic Fatty Liver Disease/epidemiology , Pediatric Obesity/epidemiology , Adolescent , Alanine Transaminase/blood , Aspartate Aminotransferases/blood , Biomarkers/blood , Body Mass Index , Chi-Square Distribution , Child , Cross-Sectional Studies , Elasticity Imaging Techniques , Female , Humans , Hypertension/diagnosis , Hypertension/epidemiology , India/epidemiology , Lipids/blood , Liver Cirrhosis/blood , Liver Cirrhosis/diagnostic imaging , Logistic Models , Male , Non-alcoholic Fatty Liver Disease/blood , Non-alcoholic Fatty Liver Disease/diagnostic imaging , Pediatric Obesity/diagnosis , Platelet Count , Predictive Value of Tests , Prevalence , Risk Factors
SELECTION OF CITATIONS
SEARCH DETAIL