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Clin Transl Oncol ; 24(10): 2039-2043, 2022 Oct.
Article in English | MEDLINE | ID: mdl-35739349

ABSTRACT

PURPOSE: To explore the benefit yielded by radiotherapy (RT), we report a series of metastatic renal cell carcinoma (RCC) patients treated with concomitant RT plus Nivolumab. METHODS/PATIENTS: Patients undergoing Nivolumab treatment plus concomitant RT (ablative or palliative) were included. RT was defined Ablative if >5 Gy/fraction were delivered. RESULTS: Ablative RT intent was the only independent predictor of both progression free and overall survival (HR 3.51, 95% CI 1.6-7.5, p = 0.0012 and HR 2.8, 95% CI 0.99-8.07, p = 0.05, respectively). CONCLUSION: Ablative RT may improve oncologic outcomes in selected patients with metastatic RCC treated with Nivolumab as compared to palliative RT.


Subject(s)
Carcinoma, Renal Cell , Kidney Neoplasms , Radiosurgery , Humans , Immune Checkpoint Inhibitors , Nivolumab
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