Dynamic mechanisms of exercise to improve body satisfaction: Perceived or actual fat loss?

We examined the dynamic mechanisms of aerobic training (AT) and strength training (ST) to improve body satisfaction. Sixty-six participants were randomised to either the AT or ST condition and completed an 8-week intervention. Participants completed 3 weekly, 30-minute sessions of moderate intensity AT (65-75% VO2 max) or ST (65-75% 1-RM). The energy consumption of each session was approximately equivalent under both conditions. Body satisfaction, body composition, perceived fitness and exercise self-efficacy were measured at baseline and biweekly during the intervention. Exercise improved individuals' body satisfaction (p < .05). When the energy expenditures of AT and ST were equal, there was no difference in body satisfaction improvement. There were dynamic mechanisms underlying the effects of exercise on body satisfaction. Specifically, perceived fitness influenced body satisfaction improvements during the early stages of the exercise program, while changes in body composition influenced body satisfaction toward the end of the exercise program. There were sex differences in the mechanisms underlying body satisfaction. For women, perceived fat was more important in the early intervention period; for men, actual body fat was more valuable in the late intervention period. An effective strategy to improve body satisfaction is to initially target perceived fitness before focusing on changing body composition.

You don't know why you (don't) exercise: The relationship between automatic processes and physical activity (or sedentary behavior): A meta-analysis.

OBJECTIVES: This meta-analysis aimed to examine the relationship between automatic processes and behavior as well as their moderators. METHODS: There were 126 effect sizes (Fisher's Z) extracted from 55 independent research studies involving 10,432 participants. Meta-analyses were conducted using Comprehensive Meta-Analysis Version 3.3. Univariate meta-regression models were used to analyze underlying moderators. RESULTS: Meta-analysis after correction found that automatic processes could significantly and positively predict behavior, but the effect size was small (Fisher's Z = 0.057, p < 0.001, 95% CI [0.043, 0.070]). CONCLUSIONS: Different components of automatic processes, task reliability, and study design moderated the relationship between automatic processes and behavior. Future research could explore automatic measures at a neurophysiological level or use population-matched stimuli for specific populations to improve measure validity. In addition, future research should accumulate evidence on how to reduce sedentary behavior.

To run or not to run? Differences in implicit attitudes towards running: An EEG study.

OBJECTIVE: To understand the reasons for individuals do or do not exercise, we examined differences in implicit (affective and instrumental) attitudes between runners and non-runners. METHODS: In conjunction with electroencephalography (EEG) technology, 31 participants completed the affective and instrumental implicit associations test (IAT). RESULTS: Behavioural results showed that runners had more positive implicit (affective and instrumental) attitudes than non-runners. EEG results further explained the underlying mechanisms for the differences, namely that runners had higher cortical functional connectivity in the compatible condition than in the incompatible condition, while non-runners had the opposite results. CONCLUSIONS: Higher levels of neural processing efficiency were required for runners to perceive affective expectations towards running. Furthermore, ERP indicators (N1 amplitudes of incompatible tasks) can be used as valid criteria for potentially predicting exercise. This contributed to understanding why individuals do or do not exercise. Further research should focus on the effects of implicit attitudes towards exercise.

Is approaching sedentary behaviour or physical activity a reward? An EEG study.

OBJECTIVE: To understand why individuals (do not) exercise, our study examined differences in approach and avoidance tendencies towards physical activity and sedentary behaviours among runners and non-runners, especially at the neural level. METHODS: Using electroencephalography (EEG), 31 participants completed an approach-avoidance task. RESULTS: We found that at the behavioural level, non-runners were faster to approach sedentary behaviour relative to runners. However, at the neural level, they both had a tendency to avoid physical activity. Specifically, avoiding physical activity had less conflict monitoring (smaller N1), required more cognitive processes (larger P3), and was more neurologically efficient (higher alpha coherence). CONCLUSIONS: These results supported the theory of effort minimization in physical activity (TEMPA), with both runners and non-runners regarding sedentary behaviour as a reward. DATA AVAILABILITY STATEMENT: The authors confirm that the data supporting the findings of this study are available within the article [and/or] its supplementary materials.

Can placebo and nocebo affect post-exercise executive function?

This study examined the placebo and nocebo effects of conditioning and induced expectations on executive function after acute aerobic exercise. The results showed that the benefits of exercise on executive function were influenced by both conditioning and induced expectations. Further, positive conditioning or expectations enhanced cognitive benefits, negative conditioning or expectations reduced cognitive benefits, but induced expectations on executive function were not moderated by conditioning. This study revealed and quantitively estimated the placebo and nocebo effects in improving executive function after acute aerobic exercise, providing evidence to advance the understanding of the cognitive benefits of exercise.

Can acute exercise be more pleasant? Using audiovisual stimuli: A meta-analysis.

This meta-analytic study aimed to examine the effects of audiovisual stimuli on affective responses during and after exercise and their moderators. A total of 296 effect sizes (Hedge's g) were extracted from 46 independent studies covering 1292 participants. Meta-analysis was performed using Comprehensive Meta-Analysis Version 3.3, and potential moderating variables were analysed using univariate meta-regression models. Audiovisual stimuli increased affective valence during (g = 0.793, 95% CI [0.666, 0.920]) and after exercise (g = 0.792, 95% CI [0.567, 1.016]), and arousal during (g = 0.920, 95% CI [0.742 1.097]) and after exercise (g = 0.666, 95% CI [0.390, 0.962]). There may be publication bias in the meta-analysis, but the main findings are still valid. The type of audiovisual stimuli (audio-video > audio or video), exercise habits (active > not reported), and exercise intensities (self-selected > imposed) moderated the effects. In conclusion, the application of audiovisual stimuli during exercise can elicit positive affective responses. These results provide a viable intervention strategy for exercise and health practitioners to reduce the number of physically inactive individuals and improve exercise compliance and adherence.

Expectations Come True: The Placebo Effect of Exercise on Affective Responses.

Objective: This study investigated the placebo and nocebo effects of habitual and induced expectations. Methods: In Study 1, 95 participants (Mage = 19.65 ± 2.21 years, MBMI = 21.94 ± 2.55) were grouped according to habitual expectations (positive, neutral, or negative) and completed a 30-min moderate-intensity aerobic exercise, and their affective response, rating of perceived exertion (RPE), and heart rate variability (HRV) were measured before, during, and after the exercise. In Study 2, the participants from Study 1 were grouped according to induced expectations (control, positive, or negative) and completed a 30-min moderate-intensity aerobic exercise. Affective response, RPE, and HRV were measured before, during, and after exercise. Results: In Study 1, positive habitual expectations increased affective response during and after exercise [F(2, 92) = 2.959, p = .057, ηp2 = .060], and negative habitual expectations increased RPE during exercise [F(2, 92) = 5.174, p = .007, ηp2 = .101]. In Study 2, positive induced expectation increased affective response during [F(2, 86) = 5.492, p = .006, ηp2 = .113] and after exercise [F(2, 86) = 6.096, p = .003, ηp2 = .124] and was not affected by habitual expectation. Conclusion: The affective response during and after exercise is influenced by habitual and induced expectations. Positive expectations enhance affective benefits, while negative expectations reduce affective benefits.

Differential proteins in esophageal squamous cell line EC9706/CDDP identified by SILAC quantitative proteomic approach / 药学学报

Multidrug resistance (MDR) is one of the main causes leading to the failure in cancer treatment. Differential proteins between esophageal squamous cell carcinoma (ESCC) cell line EC9706 and its cisdiamminedichloroplatinum (CDDP)-resistant subline EC9706/CDDP revealed by quantitative analysis may provide deeper insights into the molecular mechanisms of MDR implicated in ESCC. EC9706/CDDP was generated by exposure of its parental sensitive EC9706 to a step-wise increase of CDDP concentration during EC9706 cultivation. The stable isotope labeling with amino acids in cell culture (SILAC) was used to label EC9706 and EC9706/CDDP with heavy and light medium, separately. Mixed peptides derived from EC9706 and EC9706/CDDP were analyzed by high performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS/MS) and subsequently subjected to bioinformatics analysis to identify differential proteins between EC9706 and EC9706/CDDP. Compared to parental EC9706, EC9706/CDDP manifested phenotypes of slow proliferation, cell pleomorphology, atypia and increased resistant-index 3.23. Seventy-four differential proteins identified in the present study belongs to various families with multiple functions, such as cytoskeleton (20%), energy metabolism (11%), transcription regulation and DNA repair (11%), redox homeostasis (9.5%), protein biosynthesis and mRNA processing (12%), ribosome constituent (8.1%), molecular chaperone (8.1%), immunity/inflammation (5.4%), intracellular transport (5.4%) and nucleosome assembly (2.7%), which indicated that development of MDR is a complicated process involving dysregulation of multiple molecules and pathways. The data is of great value for in-depth elucidation of molecular mechanisms of the MDR implicated in ESCC and may represent potential molecular targets for future therapeutic development.