Predictors of hospitalizations for diabetes in Germany: an ecological study on a small-area scale.

OBJECTIVES: Our objective was to evaluate the role of potential predictors in explaining spatial variation among diabetes hospitalization rates in Germany. STUDY DESIGN: This was an ecological analysis using hospital routine data. METHODS: County-level hospitalization rates (n = 402) in 2015 were calculated based on the German Diagnosis Related Groups database. We used a funnel plot to identify counties with high hospitalization rates. To examine the impact of predictors such as socio-economic status or structure of primary care, we performed linear and logistic regression analyses. RESULTS: The crude hospitalization rate was 262 admissions per 100,000 population. In multivariable logistic models, we found the percentage of employees with academic degree (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.56-0.91), high hospital bed rate (4th quartile vs 1st quartile; OR: 2.73, CI: 1.03-7.24), and diabetes prevalence (OR: 1.49, CI: 1.17-1.90) to be significant predictors for high hospitalization rates. In multivariable linear models, the percentage of unemployed (regression coefficient b: 4.79, CI: 0.81-8.78) and rurality (b: 0.52, CI: 0.19-0.85) explained the variation in addition to predictors from logistic regression. Primary care structure was not a significant predictor in multivariable models. CONCLUSIONS: The non-significant impact of primary care in adjusted models casts the use of diabetes hospitalizations as indicators for access and quality of primary care into doubt. Diabetes hospitalizations may rather reflect demand for care.

[Are hospital administrative data suitable for external quality assurance? Comparison of quality indicators based on separate statutory data collections (BQS) and hospital administrative data]. / Krankenhaus-Routinedaten zur externen Qualitätssicherung? Vergleich von Qualitätsindikatoren anhand der Daten der gesetzlichen externen Qualitätssicherung (BQS) und Routinedaten.

BACKGROUND: German hospitals are obliged legally to provide clinical data for external comparative quality assurance. Data rely on administrative data and just as on additional data collections for this purpose only. They are used to identify defined quality indicators (so-called BQS data). The Agency for Healthcare Research and Quality (AHRQ) also developed quality indicators that rely on hospital administrative data to evaluate the quality of inpatient care. METHODS: Six selected quality indicators were computed by both methods. 2007 data from the nationwide external quality assurance program were analyzed and compared to quality information derived from a 2007 10 % nationwide sample of administrative hospital data. RESULTS: Regarding the indicators "Obstetric trauma", "Mortality of community acquired pneumonia", "Postoperative deep vein thrombosis" and "Postoperative pulmonary embolism" rates are significantly higher in hospital administrative data than in BQS data (p < 0.01). Inversely, rates of the indicator "Decubitus ulcer" are significantly lower (p < 0.001). CONCLUSION: Possible causes for the results might be divergent motivations for data collection or restrictions in data collection. It remains unclear which method properly reflects the true status. Selected indicators (e. g. obstetric trauma), however, are suitable to be substituted by hospital administrative data.

Adipokines in cord blood and risk of wheezing disorders within the first two years of life.

BACKGROUND: Adipokines are involved in the regulation of many inflammatory processes and are present at very high concentrations in cord blood of term infants. OBJECTIVE: We analysed data of a large prospective birth cohort study to examine whether adiponectin and leptin concentration in cord blood are determinants of wheezing disorders in children within the first 2 years of life. METHODS: Seven hundred and forty mothers and their newborns were included in this analysis. Adiponectin and leptin concentrations were measured in cord blood. The cumulative incidence of physician-reported asthma or obstructive bronchitis was recorded during a 2-year follow-up. RESULTS: During the first 2 years of life, asthma or obstructive bronchitis was reported by the caring paediatricians for 157 (19.6%) of the children. We found a strong interaction of cord blood adiponectin and history of atopic disease in the mother with respect to the risk of physician-reported asthma or obstructive bronchitis (P=0.006). Compared with children with cord blood levels in the middle quintile (reference category), the odds ratios for physician-reported asthma or obstructive bronchitis in the bottom quintile and top quintile were 0.14 [95% confidence interval (CI) 0.02-0.90] and 2.12 (95% CI 0.67-6.66), respectively (P for trend=0.0003), among children of mothers with a history of atopy. This association was independent of other established risk factors. Leptin levels in cord blood were not associated with risk of asthma or obstructive bronchitis. CONCLUSIONS: In children of mothers with a history of atopy, concentrations of adiponectin in cord blood could play an important role in determining risk of wheezing disorders in early childhood.

Duration of breastfeeding and risk of overweight in childhood: a prospective birth cohort study from Germany.

BACKGROUND: Whereas a recently published meta-analysis showed that ever breastfeeding reduces the risk of obesity in childhood significantly, the recent literature describing the relationship between duration of breastfeeding and risk of overweight or obesity in childhood remains inconclusive. METHODS: Between November 2000 and November 2001, all mothers and their newborns were recruited after delivery at the Department of Gynecology and Obstetrics at the University of Ulm, Germany. Active follow-up was performed at the age of 12 months and 24 months. RESULTS: Of the 1066 children included in the baseline examination, information on body mass index was available for 855 (80%) at the 2-year follow-up. At this age 72 children (8.4%) were overweight and 24 (2.8%) were severely overweight. Whereas 76 children (8.9%) were never breastfed, 533 children (62.3%) were breastfed for at least 6 months, and 322 children (37.7%) were exclusively breastfed for at least 6 months. Compared to children who were breastfed for less than 3 months, the adjusted odds ratio (OR) for overweight was 0.4 (95% confidence interval (CI) 0.2-0.8) in children who were breastfed for at least 6 months. When considering the time of exclusive breastfeeding, the adjusted OR for overweight was 0.8 (95% CI 0.4; 1.5) in children who were exclusively breastfed for at least 3 but less than 6 months and 0.4 (95% CI 0.2; 0.9) in children who were exclusively breastfed for at least 6 months compared to children who were exclusively breastfed less than 3 months. CONCLUSION: These results highlight the importance of prolonged breastfeeding for the prevention of overweight in children.

Breastfeeding, soluble CD14 concentration in breast milk and risk of atopic dermatitis and asthma in early childhood: birth cohort study.

BACKGROUND: Breast milk contains a variety of bioactive substances, among them, soluble CD14 (sCD14), which plays an important role in innate immunity. OBJECTIVE: We analysed data of a large prospective birth cohort study to examine the determinants of sCD14 in breast milk, and investigated whether breastfeeding practice and sCD14 concentrations in breast milk are determinants of the risk of atopic dermatitis (AD) and asthma in children. METHODS: Eight hundred and three mothers and their newborns were included in this analysis. We measured sCD14 concentrations in breast milk samples collected 6 weeks post-partum. During a 2-year follow-up the cumulative incidences of AD and asthma were recorded. RESULTS: Overall, AD was reported for 20.6% of the 2-year-olds and asthma was reported for 19.6%. We found the lowest incidence of physician-reported AD in children of mothers without a history of atopic diseases if breastfed for 6 to less than 9 months. Furthermore, we found an inverse association between duration of breastfeeding and risk of asthma, which was especially evident in children with mothers without a history of atopic disease (P=0.01). These patterns persisted after control for other factors by multivariate analysis methods. The protective effect of breastfeeding seemed to be synergistic with sCD14 concentrations in breast milk (P for trend 0.0005). CONCLUSIONS: The results of this prospective birth cohort study suggest that a longer duration of breastfeeding does decrease the risk for asthma in early childhood, especially in children of mothers without a history of atopic disease. The beneficial effects of breastfeeding might be further supported by high levels of sCD14 in breast milk.

p53 autoantibodies in patients with primary ovarian cancer are associated with higher age, advanced stage and a higher proportion of p53-positive tumor cells.

Autoantibodies (AAb) directed against the nuclear phosphoprotein p53 can be detected in patients with various forms of cancer. The objective was to determine the prevalence of p53 AAb at the time of diagnosis in ovarian cancer patients and to correlate the presence of p53 AAb with clinicopathological parameters. Sera of 83 patients were analyzed by an ELISA using p53 expressed from a human wild-type cDNA. p53 AAb were detectable at all stages. The overall prevalence was 46%. p53 AAb were more frequent in patients with higher age (p = 0.014), postmenopausal status (p = 0.050), or advanced tumor stage (p = 0.046). p53 AAb positivity was related to the proportion of cells positive in immunohistochemistry but not with the staining intensity. In bivariate analysis, patients with p53 AAb had a 1.96-fold risk for relapse (95% confidence interval 1.02-3.78).

Factors affecting bone demineralization and blood lead levels of postmenopausal women--a population-based study from Germany.

We investigated the influence of various lifestyle factors on blood lead levels in postmenopausal women from the general population of Germany. Particular consideration was given to those factors which are suspected to be related to bone demineralization. The study population consisted of 424 women, aged 45 to 80 years, who were examined in a substudy of the National Health and Nutrition Survey called VERA (Verbundstudie Ernährungserhebung, und Risikofaktorenanalyse) from 1987 to 1988. Mean blood lead level was 61.4 micrograms/liter (SD, 27.3). In multiple linear regression analysis alcohol consumption, former use of oral contraception, hematocrit, and age were positively associated with blood lead levels, whereas calcium intake and high physical activity showed a negative association with blood lead levels. Some of the identified risk factors which are suspected to exert their influence on blood lead levels by affecting bone demineralization can be influenced by change of individual behavior. Thus, we conclude that reduction of alcohol consumption, adequate calcium intake, and physical activity may reduce blood lead levels as well as negative health effects of osteoporosis in postmenopausal women.

Alcohol consumption and smoking habits as determinants of blood lead levels in a national population sample from Germany.

We investigated the influence of various lifestyle factors on blood lead levels in a representative sample from the general adult population (i.e., > or = 18 y of age) of West Germany in 1987-1988. The overall mean blood lead level was 73 microg/l (standard deviation = 41.4 microg/l) in 834 men and 54 microg/l (standard deviation = 26.8 microg/l) in 1,065 women. In a multiple linear regression analysis, alcohol consumption accounted for the largest proportion of variability in blood lead levels, followed by both age and smoking. Other significant contributing factors were gender, hematocrit, calcium intake, and consumption of milk and milk products. Wine had a greater effect on blood lead levels than beer (i.e., per g of alcohol consumed). With respect to cigarette smoking (i.e., no. of cigarettes smoked/d), filterless cigarettes were associated with higher blood lead levels than filter-tipped cigarettes. In addition, smoking cigars, cigarillos, or a pipe resulted in higher blood lead levels than smoking only cigarettes. Alcohol consumption and smoking were independent contributors to blood lead levels in both men and women, but effects of alcohol consumption were stronger in women than in men. We concluded that consumption of alcohol and tobacco represent major avoidable sources of lead exposure.