Occurrence, distribution and risk assessment of antibiotics and pesticides in mariculture area around Liaodong Peninsula.

Mariculture stands as a pivotal enterprise aimed at enhancing the quality of human existence. However, the utilization of antibiotics and pesticides in the mariculture process poses threats to both the environment and human well-being. Therefore, it is of great significance to investigate the occurrence, distribution and risk of antibiotics and pesticides in mariculture areas. In this study, 11 kinds of antibiotics and 12 kinds of pesticides were screened in four mariculture areas around Liaodong Peninsula in China. The pollution characteristics of pollutants were investigated in three different mariculture stages. The pollution in the reproduction stage was the most serious, indicating that mariculture may have a potential impact on the surrounding seawater. Health risk assessment results indicate that the pollutants have a significant risk to human health, therefore it is necessary to strengthen the control of chemicals used in mariculture in future.

Chemo- and Diastereoselective Cycloisomerization/[2 + 3] Cycloaddition of Enynamides: Synthesis of Spiropyrazolines as Potential Anticancer Reagents.

A silver-catalyzed one-pot cycloisomerization/[2 + 3] cycloaddition of enynamides with in situ generated nitrile imines has been developed. Unlike the well-established cycloisomerization/[4 + n] cycloadditions of enynamides, this strategy provides efficient access to a new type of spiropyrazolines, which exhibit an anti-proliferation effect on multiple tumor cell lines. The compound 3u exhibits obvious anticancer activity by inducing apoptosis in RKO cells. The combination of compound 3u and an autophagy inhibitor could improve its anti-proliferation capacities.

Catalytic asymmetric [3 + 2] cycloaddition of pyrazolone-derived MBH carbonate: highly stereoselective construction of the bispiro-[pyrazolone-dihydropyrrole-oxindole] skeleton.

A catalytic asymmetric construction of the bispiro[pyrazolone-dihydropyrrole-oxindole] skeleton catalyzed by chiral DMAP-derived catalyst was successfully achieved by employing recently explored pyrazolone-derived MBH carbonate in high yields with excellent stereoselectivities. The proposed transition state indicated that the intermolecular hydrogen bonds and π-π interactive forces played an essential role in stereoselective chemical transformation.