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1.
Medicina (Kaunas) ; 59(3)2023 Mar 11.
Article in English | MEDLINE | ID: mdl-36984554

ABSTRACT

Background and Objectives: Atherosclerosis is one of inflammatory bowel disease's most significant cardiovascular manifestations. This research aimed to examine the relationship between biochemical, haemostatic, and immune parameters of atherosclerosis and ulcerative colitis patients and its relationship to platelet aggregation. Materials and Methods: A clinical, observational cross-sectional study was performed, during which the tested parameters were compared in the experimental and control groups. The patients were divided into four groups. The first group had 25 patients who had ulcerative colitis and atherosclerosis. The second group included 39 patients with ulcerative colitis without atherosclerosis. The third group comprised 31 patients suffering from atherosclerosis without ulcerative colitis, and the fourth group comprised 25 healthy subjects. Results: In our study, we registered statistically higher levels of inflammatory markers like SE, CRP, Le, fecal calprotectin, TNF-α, and IL-6, as well as the higher value of thrombocytes and thrombocyte aggregation in the group of patients with ulcerative colitis compared to the control group. Lower levels of total cholesterol and LDL were also recorded in patients with ulcerative colitis and atherosclerosis and ulcerative colitis without atherosclerosis compared to healthy control. Triglyceride and remnant cholesterol were higher in patients with ulcerative colitis and atherosclerosis when compared to patients with ulcerative colitis and healthy control but lower than in patients with atherosclerosis only. Conclusions: Several inflammatory markers and platelet aggregation could be good discrimination markers for subjects with ulcerative colitis with the highest risk of atherosclerosis.


Subject(s)
Atherosclerosis , Cardiovascular Diseases , Colitis, Ulcerative , Inflammatory Bowel Diseases , Humans , Colitis, Ulcerative/complications , Platelet Aggregation , Cross-Sectional Studies , Cardiovascular Diseases/complications , Inflammatory Bowel Diseases/complications , Inflammation , Biomarkers , Cholesterol , Atherosclerosis/complications
2.
Medicina (Kaunas) ; 58(10)2022 Oct 01.
Article in English | MEDLINE | ID: mdl-36295542

ABSTRACT

Follicular lymphoma is the most common indolent non-Hodgkin's lymphoma and is usually initially detected in lymph nodes. Primary extranodal NHL is most commonly primarily localized in the gastrointestinal tract. We present one unusual case of ileum FL with ascites as the first clinical sign. The 73-year-old female patient was presented to the emergency department for evaluation of mild abdominal pain and abdominal swelling that had been going on for three days followed by bloating and occasional pain in the spine. The abdominal contrast-enhanced CT revealed the contrast stagnation in the distal part of the ileum. The ileum wall about 11 cm in length was thickened up to 2.9 cm and the tumor mass infiltrated all layers of ileum mesenteric lymphadenopathy up to 2 cm in diameter and significant ascites. On the upper ileum wall, the vegetative mass was described 3 cm in diameter. The patient had an emergent laparotomy with the ileocolic resection and latero-lateral ileocolic anastomosis. The microscopy finding of terminal ileum and the regional lymph nodes showed domination of cleaved cells with irregular nuclei which correspond to centrocytes. There were 0-15 large non-cleaved cells corresponding to centroblast in the microscopy high-power field. The final diagnosis was follicular lymphoma, the clinical stage 2E and histological grade by Berard and Mann criteria 1-2.


Subject(s)
Lymphoma, Follicular , Lymphoma, Non-Hodgkin , Female , Humans , Aged , Lymphoma, Follicular/complications , Lymphoma, Follicular/diagnosis , Lymphoma, Follicular/pathology , Ascites/pathology , Lymphoma, Non-Hodgkin/diagnosis , Lymphoma, Non-Hodgkin/pathology , Lymph Nodes/pathology , Abdomen
3.
Int J Med Sci ; 11(9): 936-47, 2014.
Article in English | MEDLINE | ID: mdl-25076849

ABSTRACT

OBJECTIVE: Progression from ulcerative colitis (UC) toward colorectal carcinoma (CRC) is multistep process that includes gene alterations of tumor suppressor genes, such as p53 and p16. The aim of this study was to investigate the expression patterns of p16, p53 and VEGF in affected tissue and serum levels of cytokines TNF-α, IFN-γ, IL-4, IL-6, IL-10 and IL-17 in patients with UC and CRC, respectively. MATHERIALS AND METHODS. Serum levels of cytokine in patients with UC (n=24) and CRC (n=75) and in a healthy group (n=37) were analyzed by ELISA. Endoscopic biopsies specimens of UC and CRC were studied by immunohistochemical staining for p16, p53 and VEGF. RESULTS: Patients with UC with presence of extraintestinal manifestations, complications, and positive staining of p16, p53 and VEGF respectively had higher serum levels of pro-inflammatory cytokines. Higher percentage of CRC patients had positive staining of p16, p53 and VEGF. CRC patients with positive staining of VEGF had decreased systemic values of pro-inflammatory IFN-γ and increased values of immunosuppressive IL-10. CONCLUSIONS: Relatively low IL-10 in patients with severe UC is insufficient to compensate IL-6 secretion and subsequently enhanced type 1/17 immune response. In UC patients, p16 and p53 induce enhanced VEGF expression and subsequent production of pro-inflammatory TNF-α and IL-6. In CRC patients VEGF seems to have immunosuppressive role. It appears that tumor suppressor gene-VEGF axis have dual role on immune response in inflammation of UC and tumor growth and progression of CRC.


Subject(s)
Colitis, Ulcerative/genetics , Colorectal Neoplasms/genetics , Inflammation/immunology , Tumor Suppressor Protein p53/biosynthesis , Vascular Endothelial Growth Factor A/biosynthesis , Adult , Aged , Carcinogenesis/genetics , Colitis, Ulcerative/immunology , Colitis, Ulcerative/pathology , Colorectal Neoplasms/immunology , Colorectal Neoplasms/pathology , Cytokines/biosynthesis , Cytokines/immunology , Female , Humans , Immunomodulation/genetics , Inflammation/genetics , Inflammation/pathology , Interferon-gamma/biosynthesis , Interferon-gamma/immunology , Male , Middle Aged , Th1 Cells/immunology , Th17 Cells/immunology , Vascular Endothelial Growth Factor A/genetics , Vascular Endothelial Growth Factor A/immunology
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