[Clinical effect of X-N advancement flap in repairing pressure ulcer on the buttock or back].

Objective: To explore the clinical effect of X-N advancement flap in repairing pressure ulcer on the buttock or back. Methods: From June 2018 to June 2019, 20 patients with grade Ⅳ pressure ulcers on the buttock or back were hospitalized and treated in the Department of Traumatology, Burns and Plastic Surgery of Fourth Affiliated Hospital of Guangxi Medical University, including 15 males and 5 females, aged 48-89 years. The area of the patient's wound was 8 cm×5 cm-15 cm×12 cm after debridement, and all were repaired with the X-N advancement flap designed by the author. The flap was designed according to the direction of skin relaxation on both sides of the wound, and the skin was incised in X-shape and sutured in N-shape. The width and advancement distance of the flap were recorded, and the ratio of the advancement distance to the width of the flap was calculated. The flap survival, complication, and follow-up were observed and recorded. Results: The width of the flap was (5.9±1.2) cm, the advancement distance of the flap was (10.3±2.5) cm, and the ratio of the advancement distance to the width of the flap was 1.8±0.4. All the flaps survived, and none of the flaps had blood flow disorder. Local dehiscence occurred in the flap of one patient 1 week after surgery, which was healed after laying on the floating bed, strengthened care, and wound dressing change. The flap of one patient developed infection 5 days after surgery, which was healed after partial suture removal, smooth drainage, and replacement with sensitive antibiotics. The wounds of the remaining 18 patients were all cured. After 3 months of follow-up, the flaps survived well with good elasticity and texture. Conclusions: The X-N advancement flap can make the skin and soft tissue move forward effectively. It is simple and effective to repair pressure ulcers on the back or buttock of patients with this flap, which is worthy of clinical promotion and application.

[Retracted: Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen].

Objective: To describe the characteristics of clinical manifestations and epidemiology of children with 2019 novel coronavirus (2019-nCoV) infection. Methods: All 34 children with laboratory-confirmed 2019-nCoV infection by quantitative real-time reverse transcription-PCR through nasopharyngeal swab specimens were admitted to the Third People's Hospital of Shenzhen from January 19 to Febuary 7, 2020. Clinical data and epidemiological history of these patients were retrospectively collected and analyzed. Results: Among the 34 cases, 14 were males, and 20 were females. The median age was 8 years and 11 months. No patients had underlying diseases. There were 28 children (82%) related with a family cluster outbreak. There were 26 children (76%) with a travel or residence history in Hubei Province. These patients could be categorized into different clinical types, including 22 (65%) common cases, 9 (26%) mild cases and 3 (8.8%) asymptomatic cases. No severe or critical cases were identified. The most common symptoms were fever (17 cases, 50%) and cough (13 cases, 38% ). In the 34 cases, the white blood cell counts of 28 cases (82%) were normal. Five cases had white blood cell counts more than 10×10(9)/L. One case had white blood cell counts less than 4×10(9)/L. Neutropenia and lymphopenia was found in one case, respectively. C-reactive protein levels and erythrocyte sedimentation rates were elevated in 1 and 5 case, respectively. Elevated procalcitonin was found in 1 case and D-Dimer in 3 cases. The levels of lactic dehydrogenase (LDH) were more than 400 U/L in 10 cases. The CT images of these patients showed bilateral multiple patchy or nodular ground-glass opacities and/or infiltrating shadows in middle and outer zone of the lung or under the pleura. Twenty patients were treated with lopinavir and ritonavir. Glucocorticoids and immunoglobulin were not used in any cases. All the cases improved and were discharged from hospital. Further following up was need. Conclusions: The clinical manifestations in children with 2019-nCoV infection are non-specific and are milder than that in adults. Chest CT scanning is heplful for early diagnosis. Children's infection is mainly caused by family cluster outbreak and imported cases. Family daily prevention is the main way to prevent 2019-nCoV infection.

[Relationship between upper airway volume and polysomnography parameters of patients with obstructive sleep apnea hypopnea syndrome].

Objective:To study the relationship among upper airway volume of naso-pharyngeal, yelo-pharyngeal,glosso-pharyngeal, hypo-pharyngeal area which measured by spiral computed tomography three-dimensional reconstruction technique, apnea hypopnea indexes, and the lowest oxygen saturation in patients with OSAHS.Method:①fifty-one patients with OSAHS were received polysomnography, and then were divided into groups by the AHI,LSaO2 values. ②To measure upper airway volume at normal breath and Müller maneuver state using spiral computed tomography three-dimensional reconstruction technique of CT measurement, and to calculate volume change rate and observe the upper airway compliance. ③To analyses the relationship between upper airway volume and AHI,LSaO2 values.Result:The smallest upper airway volume of OSAHS was at the velo-pharyngeal level; the volume of velo-pharyngeal level were negatively correlated with AHI during normal respiration and Müller's maneuver state and were positively correlated with LSaO2; the volume of hypo-pharyngeal were negatively correlated with AHI during normal respiration; the volume of glosso-pharyngeal were positively correlated with LSaO2 during Müller's maneuver state.Conclusion:①The volume of velo-pharyngeal level with OSAHS patients can reflect the severity of AHI,LSaO2. ②The measurement of upper airway volume using spiral computed tomography three-dimensional reconstruction technique is good method to evaluate the upper airway compliance of OSAHS patients.

[Functional modified periauricular incision in parotidectomya].

Objective:The purpose of this study was to present the usefulness of modified periauricular incision in parotid surgical procedures. Method:Sixteen consecutive partial superfacial parotidectomies were performed using modified periauricular incision. Clinical evaluation of cosmetic satisfaction, incidence of complications such as Frey's syndrome, facial nerve palsy, earlobe numbness and salivary fistula were observed. Result:The parotid tumors were removed in all cases with need for any further skin procedures, as the incisions produced a good aesthetic result. The average scale of cosmetic satisfaction are 9.2. Temporary paralysis of the facial nerve were found in two patients, and six patients felt numbness around earlobe after operation. Hey all recovered in 1 to 3 months after surgery. All patient healed without salivary fistula and Frey's syndrome. No recurrence was happened during follow-up in 6 to 30 months (median follow-up period was 22 months). Conclusion:The results of the present study indicate that modified periauricular incision have a high-quality and highly aesthetic option for surgical procedures concerning benign conditions of the parotid gland.

[Effects of total flavones of metasequosia on left ventricular hypertrophy due to pressure overload in rats].

OBJECTIVE: To determine the preventive and regressive effects of total flavones of metasequosia (TFM) on left ventricular hypertrophy in rats. METHOD: Left ventricular hypertrophy was inducedin by partial ligation of abdominal aorta. The rats were given ig TFM(4, 40, 400 mg.kg-1.d-1) for six weeks. RESULT: TFM markedly reduced the HW/BW, LVW/BW, myofibril diameter and Ca2+ content in left ventricles but the systolic blood pressure (SBP) in rats wasn't obviously influenced. CONCLUSION: TFM can prevent and reverse the left ventricular hypertrophy due to pressure overload in rats. The mechanism may be related to its calcium antagonistic properties.

The role of NO and B-50 in neurotoxicity of excitatory amino acids.

To investigate the direct evidence for the role which nitric oxide (NO) plays in the neurotoxicity of excitatory amino acids, we evaluated NO level by Greiss testing solution when glutamate (Glu) and kainate (KA) induced neuronal degeneration in primary cortical cultures. Glutamate-induced neurotoxicity was accompanied by a rise in NO. 5 mM hemoglobin (Hb) led to a decrease of NO content and prevented excitotoxicity induced by 1 mM glutamate. 1 mM L-arginine (L-Arg) reversed the effect of hemoglobin by raising the NO level. No change in NO content was found in KA-induced neurotoxicity, which was not affected by L-Arg, Hb or L-Arg + Hb. It is suggested that NO plays an important role in glutamate-, but not KA-induced neurotoxicity in primary cortical cultures. We also investigated the effects of glutamate on a growth-associated protein, B-50. The B-50 level declined significantly 24 h after exposure to 100 microM glutamate for 30 min and then recovered 2 days later. The effect of glutamate on B-50 was concentration-dependent. This indicates that B-50 might be involved in both glutamate neurotoxicity and the following neuronal repair process.

[Effects of oxymatrine on arrhythmia in dogs with myocardial infarction].

AIM: To study the effects of oxymatrine (Oxy) on arrhythmia in dogs with myocardial infarction. METHODS: Partly ligating the left anterior descending coronary artery in the open-chest dogs produced myocardial infarction of left anterior ventricular wall. After 5-8 d, the diastolic excitability threshold (DET), the effective refractory periods (ERP) and arrhythmias were determined by programmed electric stimulation (PES). RESULTS: Oxy (i.v. 50 mg.kg-1) increased DET from 2.53 +/- 1.28 to 3.19 +/- 1.62 V, lengthened ERP from 182 +/- 25 to 219 +/- 43 ms at normal region and from 206 +/- 49 to 235 +/- 55 ms at infarct region in left ventricle, but had no effects on dispersion of ERP, QTc interval and ventricular tachycardia (VT) or ventricular fibrillation (VF). Procainamide (Pro) (i.v. 25 mg.kg-1) increased DET and lengthened ERP and QTc interval, but decreased the dispersion of ERP. Pro prevented PES-induced VT/VF and spontaneous ischemia-related VF. CONCLUSION: The increased DET and lengthened ERP of Oxy are its anti-arrhythmic mechanism.

CaSO4:Dy and LiF:Mg, Cu, P thermoluminescent dosimeters for environmental monitoring in ambient areas of a nuclear power plant.

This paper describes CaSO4:Dy and LiF:Mg, Cu, P which were used for ambient environmental monitoring before the nuclear power plant operation in Guangdong Daya Bay, China, in 1991. Since LiF:Mg, Cu, P was first used as an environmental dosimeter in this laboratory, the intercomparison of both thermoluminescent dosimeters, including laboratory irradiation and environmental exposure in Beijing reference spots, was conducted in cooperation with National Institute of Metrology and Laboratory of Industrial Hygiene, measured values of both thermoluminescent dosimeters were in agreement with the error being less than +or- 2% for the laboratory irradiation. The results of measurement by both thermoluminescent dosimeters were quite in agreement with environmental reference exposure rates measured by a pressurized ionization chamber. The largest error of CaSO4:Dy environmental monitoring results in Daya Bay also showed that the differences of measurement results between two thermoluminescent dosimeters were not significant. The experiment results indicated that LiF:Mg, Cu, P was a good environmental dosimeter.