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1.
Inhal Toxicol ; 36(1): 26-30, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38190328

ABSTRACT

OBJECTIVE: In 1988, the Iraqi government used a range of chemical weapons (CWs) against the Iraqi Kurds of Halabja. Here, we aim to investigate the long-term health consequences in exposed survivors as they are not sufficiently studied. MATERIALS AND METHODS: This was a retrospective study conducted from November 2019 to May 2020 assessing the health status of all exposed Halabja chemical attack survivors compared to non-exposed people from the same area. RESULTS AND DISCUSSION: Two hundred thirty survivors and 240 non-exposed participants were enrolled in this study, with control participants matched to age, gender, and occupation. Among the survivors, females were more prevalent. The respiratory system was the most common single exposure route (83, 36.1%), with 138 (60%) of the survivors being exposed by multiple routes. The vast majority (88.7%) of survivors had activities of daily living (ADL) impairment. There was female predominance in mild and moderate cases, with more males in severe cases (p < 0.01). Respiratory and cardiac diseases were significantly more common in the survivors compared to the controls (p < 0.001). Survivors with multiple CW exposure routes had significantly higher rates of ADL impairment (p < 0.001) and cardiac disease, respiratory diseases, and miscarriage (p < 0.01), than those with a single exposure route. CONCLUSION: In this study comparing CW survivors with a local control population, a single, high-dose exposure to CWs was associated with significant increases in chronic respiratory and cardiac conditions, in addition to high rates of ADL impairment. Similar studies are needed in other, more recent CW survivor cohorts.


Subject(s)
Activities of Daily Living , Respiratory Tract Diseases , Male , Humans , Female , Retrospective Studies , Iraq/epidemiology , Respiratory Tract Diseases/chemically induced , Respiratory Tract Diseases/epidemiology , Survivors
2.
Int J Soc Psychiatry ; : 207640231210107, 2023 Nov 10.
Article in English | MEDLINE | ID: mdl-37947284

ABSTRACT

Genocide attempts are among the most severe traumatic events that are transmitted across generations. However, it may also prove the strength and survivability as well as the vulnerability of the targeted group. Anfal and chemical attacks on Halabja on Iraqi Kurds that targeted their annihilation had a devastating impact. Many survivors and their generations are still dealing with their effects on psychological disorders such as posttraumatic stress disorder (PTSD) and depression. To address the psychological effects of these tragic events on survivors and their generations and propose the actions to be taken, this article explores the psychological trauma and problems caused by attempted genocide and chemical attacks in the case of Anfal campaign. These effects require more research to fully understand the long-term effects of these tragedies, as well as support and provision of comprehensive psychological and mental health interventions to their survivors and generations.

3.
Hum Immunol ; 84(5-7): 311-312, 2023.
Article in English | MEDLINE | ID: mdl-37061394

ABSTRACT

Yazd City (1,200,000 inhabitants) is placed in the middle of its Iran desert province and it was constructed on a oasis in ancient times.However,it was a central point on the Silk Road and merchants from both Asia and Mediterranean/European areas crossed through Yazd City.We have studied HLA-A,-B,-DRB1 and DQB1 alleles in Yazd population.Analysys of nine most frequent extended class I and class II haplotypes shows that four of them are specific of this population.The other six haplotypes are also found in Asian and Mediterranean populations in significant frequency. This supports that the nowadays relatively isolated in desert Yazd area also contains people that may bear HLA genes probably originated because of long lasting merchants route between Europe and Asia through the European/Asian Silk Road in addition to other HLA genes close to other Iranian populations, including Kurds.


Subject(s)
HLA-A Antigens , HLA-B Antigens , HLA-DQ beta-Chains , HLA-DRB1 Chains , Middle Eastern People , Humans , Alleles , Gene Frequency , Haplotypes , Iran , Genetics, Population , Middle Eastern People/genetics
4.
Int J Equity Health ; 22(1): 6, 2023 01 07.
Article in English | MEDLINE | ID: mdl-36611171

ABSTRACT

BACKGROUND: Language has been well documented to be a key determinant of accessing healthcare. Most of the literature about language barrier in accessing healthcare is in the context of miscommunication. However, it is critical to consider the historical and political contexts and power dynamics underlying actions. The literature in this matter is short. In this paper we aimed to find out how first-language affects access to healthcare for people who do not speak the official language, with a particular focus on language oppression. METHODS: We conducted this qualitative study based on patient-reported experiences of the Kurds in Turkey, which is a century-long oppressed population. We conducted 12 in-depth interviews (all ethnically Kurdish, non-Turkish speaking) in Sirnak, Turkey, in 2018-2019 using maximum variation strategy. We used Levesque's 'Patient-Centred Access to Healthcare' framework which addresses individual and structural dimensions to access. RESULTS: We found that Kurds who do not speak the official language face multiple first-language related barriers in accessing healthcare. Poor access to health information, poor patient-provider relationship, delay in seeking health care, dependence on others in accessing healthcare, low adherence to treatments, dissatisfaction with services, and inability to follow health rights were main issues. As an unusual outcome, we discovered that the barrier processes in accessing healthcare are particularly complicated in the context of oppression and its internalization. Internalized oppression, as we found in our study, impairs access to healthcare with creating a sense of reluctance to seek healthcare, and impairs their individual and collective agency to struggle for change. CONCLUSIONS: A human-rights-based top-down policy shift, and a bottom-up community empowerment approach is needed. At the system level, official recognition of oppressed populations, acknowledgement of the determinants of their health; and incorporating their language in official capacities (particularly education and healthcare) is crucial. Interventions should include raising awareness among relevant professions and stakeholders that internalized oppression is an issue in accessing healthcare to be considered. Given that internalized oppression can be in other forms than language or ethnicity, future research aimed at examining other aspects of access to healthcare should pay a special attention to internalized oppression.


Subject(s)
Health Services Accessibility , Human Rights , Humans , Turkey , Qualitative Research , Communication Barriers , Language
5.
Hum Immunol ; 83(11): 737-738, 2022 Nov.
Article in English | MEDLINE | ID: mdl-35931633

ABSTRACT

Kurds are living at Middle East region comprising several countries (38 million people) and also have emigrated to Asia, Europe and America. Kurds from Iran have been HLA typed in the present work from Saqqez and Baneh towns, Kordestan province, Iran. Origin of Kurds is considered autochthonous from Anatolia and surrounding mountains :they have been referred as "the mountain people" by classic Persian, Greek and Roman authors. Present day Turks are also autochthonous from Anatolia, but they were not recognized by classical authors as living in the mountains and they speak a language of Asian origin that was imposed to Anatolia by a "elite" invasion without a noticeable high Asian gene input. Most frequent class I and class II HLA alleles found in Iranian Kurds population are: HLA-A*24:02, A*02:01 and HLA-B*35:01, and HLA-DRB1*11:01, DRB1*03:02 and HLA-DQB1*03:01; also, most frequent HLA extended haplotypes from this Iran Kurdish sample are not shared with Iranians but with Mediterranean, Turkish and Caucasus people. This is confirmed by Neighbour-Joining and correspondence analysis studied together with the corresponding populations. Finally, our studies show that both Kurds and Turks are genetically original from Anatolian Peninsula and surrounding countries and that an apparent Asian genetic or Aryan invasion does not exist in the area.


Subject(s)
HLA-B Antigens , Alleles , Gene Frequency , HLA-B Antigens/genetics , HLA-DQ beta-Chains/genetics , HLA-DRB1 Chains/genetics , Haplotypes , Humans , Iran , Turkey
6.
Hum Immunol ; 83(6): 477-479, 2022 Jun.
Article in English | MEDLINE | ID: mdl-35459551

ABSTRACT

Azeri people are at present day mainly living in an area which comprises North (Azerbaijan) and South (Azeri Iran provinces) parts, living the biggest population in Azeri Iran provinces with about 17-20 million people. They were studied HLA-A, -B, -DRB1 and -DQB1 allele and extended haplotype frequencies in unrelated Iranian Tabriz Azeris from a rural area close to Tabriz City. The HLA extended haplotypes with highest frequencies are: 1) HLA- A*24:02-B*35:01-DRB1*11:01-DQB1*03:01, shared with Mediterraneans and southern Russians (Chuvash, which also show Mediterranean characters); and 2) HLA-A*01:02-B*08:01-DRB1*03:01-DQB1*02:01, found also in Chuvash and other Azeri samples from Tabriz. Neí's DA HLA-DRB1 genetic distances, HLA-DRB1 Neighbour-Joining dendrogram and Vista analyses show that population with closest distance is Kurdish, followed by Iranian Gorgan and Southern Russia/ North Caucasus Chuvash; probably these latter groups and Azeris were populating North Mesopotamia/ Caucasus Mts. since prehistoric times. Kurds (in Iraq and Iran) do not speak Turk while Azeris do: they are both genetically close, but they are not genetically close to present day Anatolia (Turkey) Turks who also speak Turk language and show a typical Mediterranean HLA profile. In summary, Azeri population studies show examples that genes and languages do not correlate, contradicting the postulate asserted by others.


Subject(s)
Ethnicity , Genetics, Population , Histocompatibility Antigens , Language , Alleles , Ethnicity/genetics , Gene Frequency , HLA-A Antigens/genetics , HLA-B Antigens/genetics , HLA-DQ beta-Chains/genetics , HLA-DRB1 Chains/genetics , Haplotypes , Histocompatibility Antigens/genetics , Humans , Iran
7.
Hemoglobin ; 45(4): 239-244, 2021 Jul.
Article in English | MEDLINE | ID: mdl-34794358

ABSTRACT

Immigration impact on genetic epidemiology of thalassemia worldwide is well-recognized. Over the past decade, the Duhok Province of Northern Iraq attracted a large number of immigrants. To assess whether immigration had contributed to changes in the mutation spectrum of ß-thalassemia (ß-thal) in the region, we recruited 218 registered patients with symptomatic ß-thal. The recruited patients included 50 (22.9%) from resettled migrant families. A total of 431 ß-thal alleles were fully characterized, with 20 different thalassemia mutations, the most frequent being IVS-II-1 (G>A) (HBB: c.315 + 1G>A), IVS-I-6 (T>C) (HBB: c.92 + 6T>C), codon 5 (-CT) (HBB: c.17_18delCT), IVS-I-110 (G>A) (HBB: c.93-21G>A), codon 44 (-C) (HBB: c.135delC), codon 8 (-AA) (HBB: c.25_26delAA) and IVS-I-1 (G>A) (HBB: c.92 + 1G>A) constituting 72.8% of the total. Some differences in mutation spectrum were observed compared to earlier studies from this same province, the most notable of which were the higher frequencies of IVS-I-110 and codon 8. Interestingly, the highest proportions of alleles related to immigrants were encountered in these two allele groups. Ethnic variation was also documented, so that while Muslim Kurds had IVS-II-1, IVS-I-6, IVS-I-110, codon 5 and codon 44 as their most frequent mutations, the most frequent among Kurdish Yazidis, were codon 5, codon 44, codon 8 and IVS-I-6. These ethnic variations and changes in mutation spectrums are important and should be taken in consideration to ensure effective implementation of the thalassemia preventive program.


Subject(s)
beta-Thalassemia , DNA Mutational Analysis , Emigration and Immigration , Ethnicity , Gene Frequency , Genotype , Humans , Iraq/epidemiology , Mutation , beta-Globins/genetics , beta-Thalassemia/ethnology , beta-Thalassemia/genetics
8.
Hemoglobin ; 45(3): 212-214, 2021 May.
Article in English | MEDLINE | ID: mdl-34167424

ABSTRACT

We report a novel frameshift ß-thalassemia (ß-thal) mutation due to a two-nucleotide deletion at codon 118 of the ß-globin gene (HBB: c.356_357delTT) in a 4-year-old Iraqi Kurd female presenting as transfusion-dependent ß-thal. This frameshift mutation, unlike many others involving the third exon, behaved as a recessive ß0 defect and not as dominant ß-thal mutation.


Subject(s)
beta-Globins , beta-Thalassemia , Child, Preschool , Codon , Female , Frameshift Mutation , Humans , Iraq , beta-Globins/genetics , beta-Thalassemia/diagnosis , beta-Thalassemia/ethnology , beta-Thalassemia/genetics
9.
Cult Health Sex ; 23(7): 899-912, 2021 07.
Article in English | MEDLINE | ID: mdl-32223525

ABSTRACT

Based on fieldwork among Kurdish-Norwegian migrants, this study explored how female genital cutting (FGC) was a silenced topic between mothers and daughters, and between men and women. The silence was often broken when FGC was discussed as a practice that needed to be rejected. The main reasons for rejecting FGC were to support women's rights and to recognise the negative ways in which FGC affected women's sexuality. This way of breaking the silence on FGC was particularly helpful to some husbands and wives in their discussion of how FGC might have affected their sexual relationships. Using theories of migrant women's sexual agency and embodiment, this study examined how the silencing of FGC in close relationships can be interpreted both as a sign of oppression and as a sign of empowerment. The analysis suggests that the stigmatisation that circumcised women can experience from condemnatory public discourse on FGC may sometimes lead to the negotiation of assertive female sexuality.


Subject(s)
Circumcision, Female , Transients and Migrants , Female , Humans , Male , Mothers , Sexual Behavior , Sexuality
10.
Hemoglobin ; 44(3): 156-161, 2020 May.
Article in English | MEDLINE | ID: mdl-32588682

ABSTRACT

In order to identify the α-thalassemia (α-thal) mutation spectrum in Kurdistan Province, West Iran, a total of 217 individuals, including 154 α-thal carriers and 63 normal subjects were investigated in this study. Molecular analysis of α1- and α2-globin genes using multiplex gap-polymerase chain reaction (gap-PCR), amplification refractory mutation system (ARMS)-PCR or direct DNA sequencing, showed 11 different α-globin variants. The -α3.7 (rightward) deletion (NG_000006.1: g.34164_37967del3804) (70.32%), polyadenylation signal (polyA2) site (AATAAA>AATGAA) (αpolyA2α) (HBA2: c.*92A>G) (7.74%), -α4.2 (leftward) deletion (6.45%) and codon 59 (or Hb Adana) (G>A) (ααcodon 59) (HBA1: c.179G>A) (4.52%) were the most frequent mutations in the present study. In conclusion, the spectrum of α-thal mutations in Kurdistan Province is closest to that in western provinces of Iran (Kurdish and Laki populations). In addition, it was revealed that the codon 59 mutation is common in the Kurdish population. On the other hand, despite the same ethnic background of Kurds in Iran and Iraq, the - -MED I double gene deletion and polyA2 point mutation have different distributions in these two populations. Therefore, further studies are needed to identify the cause of these differences.


Subject(s)
Alleles , Mutation , alpha-Globins/genetics , alpha-Thalassemia/epidemiology , alpha-Thalassemia/genetics , DNA Mutational Analysis , Erythrocyte Indices , Gene Frequency , Genetic Association Studies , Genetic Predisposition to Disease , Genotype , Geography, Medical , Humans , Iran/epidemiology , Multiplex Polymerase Chain Reaction , Phenotype , Population Surveillance , alpha-Thalassemia/blood , alpha-Thalassemia/diagnosis
11.
Clin Appl Thromb Hemost ; 26: 1076029619888293, 2020.
Article in English | MEDLINE | ID: mdl-31994403

ABSTRACT

Hemophilia A (HA) is a severe coagulation disorder affecting 1 in 5000 to 10 000 male births. In severe cases, the most deleterious large DNA rearrangements are inversions of intron 22 (Inv22) and intron 1 (Inv1) of the factor VIII (FVIII) gene. These account for 40% to 50% and 1% to 5% of all causative mutations, respectively. Nevertheless, no genetic analysis to identify the actual causative mutation of FVIII, particularly Inv22 and Inv1, among Iraqi Kurdish hemophiliacs has been performed. In this study, we aimed to genotype Inv22 and Inv1 of the FVIII gene in our patients with HA and reveal the genotype/phenotype correlation with the inversion mutations and their role as a risk factor for the development of inhibitors. Analyses of the Inv22 and Inv1 mutations in 80 Iraqi Kurdish patients with HA (60 severe, 18 moderate, and 2 mild) were performed using the inverse shifting-polymerase chain reaction (IS-PCR) method. In severe cases, 46.7% (28/60) had Inv22 and 3.3% (2/60) had Inv1. The genotype/phenotype relation of Inv22 and Inv1 illustrated a statistically significant association (P = .012) between disease severity and inversion mutations. Slightly more patients with Inv22 (39%) developed inhibitors than those without Inv22 (28%; odds ratio = 1.65, 95% confidence interval = 0.56-4.87, P = .361). Inv22 is a major cause of severe HA in Iraqi Kurdish patients, and IS-PCR is a rapid, robust, and effective method that can be applied for carrier detection and prenatal diagnosis of HA in developing countries.


Subject(s)
Chromosome Inversion , Factor VIII/genetics , Hemophilia A/genetics , Introns/genetics , Genetic Association Studies , Genotype , Hemophilia A/epidemiology , Hemophilia A/ethnology , Humans , Iraq/ethnology , Male , Mutation , Polymerase Chain Reaction/methods
12.
J Ethnobiol Ethnomed ; 15(1): 59, 2019 Nov 27.
Article in English | MEDLINE | ID: mdl-31775812

ABSTRACT

BACKGROUND: Iraqi Kurdistan is a special hotspot for bio-cultural diversity and for investigating patterns of traditional wild food plant foraging, considering that this area was the home of the first Neolithic communities and has been, over millennia, a crossroad of different civilizations and cultures. The aim of this ethnobotanical field study was to cross-culturally compare the wild food plants traditionally gathered by Kurdish Muslims and those gathered by the ancient Kurdish Kakai (Yarsan) religious group and to possibly better understand the human ecology behind these practices. METHODS: Twelve villages were visited and 123 study participants (55 Kakai and 68 Muslim Kurds) were interviewed on the specific topic of the wild food plants they currently gather and consume. RESULTS: The culinary use of 54 folk wild plant taxa (corresponding to 65 botanical taxa) and two folk wild mushroom taxa were documented. While Kakais and Muslims do share a majority of the quoted food plants and also their uses, among the plant ingredients exclusively and commonly quoted by Muslims non-weedy plants are slightly preponderant. Moreover, more than half of the overall recorded wild food plants are used raw as snacks, i.e. plant parts are consumed on the spot after their gathering and only sometimes do they enter into the domestic arena. Among them, it is worth mentioning the consumption of raw wild crocus corms, also still common in Turkish Kurdistan and that of wild tulip bulbs, which was documented to be popular until the beginning of the twentieth century in the Middle East. Comparison with other ethnobotanical field studies recently conducted among surrounding populations has shown that Kurds tend to gather and consume the largest number of non-weedy wild vegetables. CONCLUSION: The collected data indicate robust traces of nomadic pastoralism in Kurdish traditional foraging. This finding confirms that studies on wild food plant gathering in the Fertile Crescent and Turco-Arabic-Iranic regions of the Middle East are crucial for understanding the possible evolution of wild food plant gathering through history within the post-Neolithic continuum between pastoralism and horticulturalism.


Subject(s)
Crocus , Plants, Edible/classification , Tulipa , Adult , Aged , Ethnicity , Ethnobotany , Female , Humans , Iraq , Male , Middle Aged , Snacks
13.
J. oral res. (Impresa) ; 8(1): 66-73, feb. 28, 2019. tab, graf, ilus
Article in English | LILACS | ID: biblio-1145293

ABSTRACT

This study evaluated the prevalence and eruption's pattern of impacted mandibular third molars (IMTM) and the influence of their eruption status on the distal caries of mandibular second molars (MSM) using cone-beam computed tomography (CBCT). Material and methods: CBCT images taken for different purposes in private dental practices were analyzed retrospectively. Radiographic assessment included: prevalence of IMTM, degree of angulation, level of impaction and type of IMTM. Furthermore, the distance between the cement-enamel junctions (CEJ) of second and third molars and the occurrence of caries lesion on the distal surface of MSM was also evaluated. Data were analyzed by chi square test and logistic regression was used to find the association between distal caries of MSM and eruption status of IMTM. Results: Three hundred and eight CBCTs were screened, the prevalence of IMTM was 36.88% and their angulation degree were mostly less than 90º (mesioangular). Amongst those with impaction, 58 subjects (43%) had distal caries on MSM, 29.6% in females and 30.4% in the age group 19-27 years. Caries on the distal side of MSM were significantly associated with age, level and type of impaction, angulation degree and CEJ distances (p<0.05). Conclusions: The prevalence of IMTM is high (36.88%) and there are significant relationships between angulation degree, level and type of impaction, and CEJ distances with caries on the distal side of MSM.


Introducción: Este estudio evaluó la prevalencia y el patrón de erupción de terceros molares mandibulares impactados (TMMI), y la influencia de su estado de erupción en la caries distal de los segundos molares mandibulares (SMM) mediante tomografía computarizada de haz cónico (TCHC). Material y métodos: se analizaron retrospectivamente las imágenes de TCHC tomadas para diferentes fines en prácticas dentales privadas. La evaluación radiográfica incluyó: prevalencia de TMMI, grado de angulación, nivel de impacto y tipo de TMMI. Además, también se evaluó la distancia entre la unión amelocementaria (UAC) de los segundos y terceros molares y la aparición de lesión de caries en la superficie distal de SMM. Los datos se analizaron mediante la prueba de chi cuadrado y se usó la regresión logística para evaluar asociaciones entre la caries distal de SMM y el estado de erupción de TMMI. Resultados: Se examinaron 308 TCHC, la prevalencia de TMMI fue de 36.88% y su grado de angulación fue mayoritariamente menor a 90º (mesioangular). Entre aquellos con impacto, 58 sujetos (43%) tenían caries distales en los SMM, 29.6% eran mujeres y 30.4% pertenecieron al grupo de edad de 19-27 años. Las caries en el lado distal de MSM se asociaron significativamente con la edad, el nivel y el tipo de impactación, el grado de angulación y las distancias UAC (p<0.05). Conclusiones: la prevalencia de TMMI es alta (36.88%) y existen relaciones significativas entre el grado de angulación, el nivel y el tipo de impacto, y las distancias UAC con presencia de caries en el lado distal de los SMM.


Subject(s)
Humans , Male , Female , Adult , Young Adult , Tooth, Impacted , Dental Caries/etiology , Dental Caries/epidemiology , Molar, Third/injuries , Bicuspid , Prevalence , Retrospective Studies , Tooth Cervix , Cone-Beam Computed Tomography , Iraq/epidemiology , Mandible/diagnostic imaging , Molar
14.
Int J Lab Hematol ; 41(1): 87-93, 2019 Feb.
Article in English | MEDLINE | ID: mdl-30216683

ABSTRACT

INTRODUCTION: Fetal hemoglobin (HbF) is the major modifier for sickle cell disease (SCD) severity. HbF is modulated mainly by three major quantitative trait loci (QTL) on chromosomes 2, 6, and 11. METHODS: Five SNPs in the three QTLs (HBG2, rs7482144; BCL11A, rs1427407 and rs10189857; and HBS1L-MYB intergenic region, rs28384513 and rs9399137) were investigated by multiplex PCR and reverse hybridization, and their roles in HbF and clinical phenotype variability in Iraqi Kurds with SCD were assessed. RESULTS: HBG2 rs7482144 with minor allele frequency (MAF) of 0.133 was the most significant contributor to HbF variability, contributing 18.1%, followed by rs1427407 (MAF of 0.266) and rs9399137 (MAF of 0.137) at 14.3% and 8.8%, respectively. The other two SNPs were not significant contributors. Furthermore, when the cumulative numbers of minor alleles in the three contributing SNPs were assessed, HbF% and hemoglobin concentration increased with increasing number of minor alleles (P < 0.0005 and 0.001, respectively), while serum lactic dehydrogenase, reticulocytes, leukocytes, transfusion, and pain frequencies decreased (P = 0.003, 0.004, <0.0005, <0.0005, and 0.017, respectively). CONCLUSIONS: It was demonstrated that SNPs in all three major HbF QTLs contribute significantly to HbF and clinical variability in Iraqi Kurds with SCD and that the cumulative number of minor alleles at contributing SNPs may serve as a better predictor of such variability in this population.


Subject(s)
Anemia, Sickle Cell/genetics , Fetal Hemoglobin/genetics , Phenotype , Polymorphism, Single Nucleotide , Alleles , Carrier Proteins/genetics , Humans , Iraq/ethnology , Nuclear Proteins/genetics , Quantitative Trait Loci , Repressor Proteins
15.
J Lab Physicians ; 10(4): 370-373, 2018.
Article in English | MEDLINE | ID: mdl-30498305

ABSTRACT

PURPOSE: Hemoglobin (Hb) F% is increased in up to half of beta-thalassemia (ß-thal) carriers. Several polymorphisms have been linked to such variability in different populations, including HBG2 - 158(C>T) (Xmn I polymorphism) on chromosome 11. To determine the role of this polymorphism in such variability among Iraqi Kurds, the current study was initiated. MATERIALS AND METHODS: A total of 102 consecutive patients diagnosed as ß-thal minor were enrolled. The enrollees had their diagnosis based on peripheral blood counts and high-performance liquid chromatography to determine HbA2 and HbF. All enrollees had their DNA extracted by phenol-chloroform method and Xmn I polymorphism detected by restriction fragment length polymorphism-polymerase chain reaction. RESULTS: The mean age (standard deviation [SD]) of the 102 enrollees was 25.4 (14.0) years, and the enrollees included 48 males and 54 females. Xmn I polymorphism was identified in heterozygous state in 46 (45.1%) patients and in homozygous state in one patient (0.98%). Thus, the minor allele frequency of this polymorphism was 0.235 in the studied group. There were no significant differences in red cell indices and HbA2% in carriers of the minor allele compared to noncarriers, while HbF% and absolute HbF concentrations were significantly higher in the former subgroup (P = 0.032 and 0.014, respectively). This polymorphism's contribution to HbF variability was found to be 5.8% in the studied sample. Furthermore, those with HbF ≥2% were 3.2 folds more likely to carry the minor allele. CONCLUSIONS: Xmn I polymorphism is frequently encountered in Iraqi Kurds with ß-thal minor, and it is significantly associated with higher fetal hemoglobin in these patients.

16.
Qual Health Res ; 28(4): 659-672, 2018 03.
Article in English | MEDLINE | ID: mdl-29251552

ABSTRACT

In this article, we explore how narrative accounts of trauma are co-constructed through the interaction between researcher and participant. Using a narrative multiple-case study with Kurdish refugee families, we address how this process takes place, investigating how researcher and participants were engaged in relational, moral, collective, and sociopolitical dimensions of remembering, and how this led to the emergence of particular ethical questions. Case examples indicate that acknowledging the multilayered co-construction of remembering in the research relationship profoundly complicates existing deontological guidelines that predominantly emphasize the researcher's responsibility in sensitively dealing with participants' alleged autobiographical trauma narratives. Instead, our analysis invites qualitative researchers to engage in a continued, context-specific ethical reflection on the potential risks and benefits that are invoked in studies with survivors of collective violence.


Subject(s)
Memory , Refugees/psychology , Researcher-Subject Relations , Belgium , Humans , Informed Consent , Narration , Patient Selection/ethics , Researcher-Subject Relations/ethics , Researcher-Subject Relations/psychology , Stress, Psychological/etiology , Stress, Psychological/psychology , Turkey/ethnology
17.
Hum Exp Toxicol ; 37(8): 836-847, 2018 Aug.
Article in English | MEDLINE | ID: mdl-29069930

ABSTRACT

In the 1980s, villages in the Kurdistan region of Iraq were exposed to chemical weapons (CWs), which killed and injured thousands of civilians. There has been no clinical assessment of the long-term effects of CWs exposure on those injured. We report the first such evaluation of CW effects on long-term health of children. Patients from the CW-exposed areas were interviewed to assess previous and current clinical history and underwent clinical examination. The status of organs known to be targets of CWs, including skin, eyes, respiratory and neuromuscular systems, was assessed. Children of similar age and social background, but with no history of CW exposure, were selected as a control population. Results showed that 70% of children in the CWs group had chronic health problems in contrast to 3.3% in the unexposed group ( p < 0.0001). Fifty-five per cent of the CW-exposed group had long-term visual impairment but none in the unexposed population. Thirty-six per cent of the CW-exposed group had chronic dermatological conditions compared with 0.8% of the unexposed group ( p < 0.0001), 31% of the CWs group had neurological sequelae compared with 0.4% of the unexposed group ( p < 0.0001) and 51% of the CWs group had long-term respiratory problems compared with 1.5% of the unexposed group ( p < 0.0001). Respiratory complaints including asthma, chronic bronchitis and bronchiectasis were particularly common. Our study suggests that CWs used were probably a combination of sulphur mustard and organophosphate nerve agents. Results also indicate that the prevalence of acute and chronic health problems following exposure to CW agents appear to be higher in children compared with reported data in adults.


Subject(s)
Chemical Warfare Agents/toxicity , Environmental Exposure/adverse effects , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Iraq/epidemiology , Male , Nervous System Diseases/chemically induced , Nervous System Diseases/epidemiology , Respiratory Tract Diseases/chemically induced , Respiratory Tract Diseases/epidemiology , Retrospective Studies , Skin Diseases/chemically induced , Skin Diseases/epidemiology , Vision Disorders/chemically induced , Vision Disorders/epidemiology
18.
Br J Sociol ; 68(2): 145-166, 2017 Jun.
Article in English | MEDLINE | ID: mdl-27885639

ABSTRACT

Against Beck's claims that conventional sociological concepts and categories are zombie categories, this paper argues that Durkheim's theoretical framework in which suicide is a symptom of an anomic state of society can help us understand the diversity of trajectories that transnational migrants follow and that shape their suicide rates within a cosmopolitan society. Drawing on ethnographic data collected on eight suicides and three attempted suicide cases of second-generation male Alevi Kurdish migrants living in London, this article explains the impact of segmented assimilation/adaptation trajectories on the incidence of suicide and how their membership of a 'new rainbow underclass', as a manifestation of cosmopolitan society, is itself an anomic social position with a lack of integration and regulation.


Subject(s)
Adaptation, Psychological , Adolescent Behavior/psychology , Social Isolation , Suicide/psychology , Transients and Migrants/psychology , Adolescent , Adult , Anthropology, Cultural , Child , Female , Humans , Interpersonal Relations , London , Male , Middle Aged , Parent-Child Relations , Psychology, Social , Residence Characteristics , Social Class , Social Mobility , Turkey/ethnology , Young Adult
19.
J Blood Med ; 1: 143-6, 2010.
Article in English | MEDLINE | ID: mdl-22282694

ABSTRACT

BACKGROUND: It is well established that ABO and rhesus (Rh) genes and phenotypes vary widely between ethnic groups and both within and between geographical areas. The aim of this study was to determine the distribution of ABO and Rh blood groups in Kurds and to compare it with those of other populations. SUBJECTS AND METHODS: The study included blood grouping of total population of 53,234 whose ABO and Rh blood groups were determined by standard methods during a period of about 5 years (2005-2009). RESULTS: The most prevalent blood group was O (37.16%), followed by blood groups A (32.47%) and B (23.84%), whereas the least prevalent blood group was AB (6.53%). The majority 91.73% were Rh positive, and 8.27% were Rh negative. Data showed that among the Rh-positive individuals, 34.03% were O, 29.99% were A, 21.69% were B, and 6.02% were AB. Break up of the Rh negatives showed that 3.13% were group O, 2.48% were A, 2.15% were B, and 0.51% were AB. CONCLUSION: Blood group O is the commonest blood group in, followed by A, B, and AB. More than 91% of the study population is Rh positive. Also, we can conclude that distribution of ABO and Rh blood groups in Kurds, in addition to being close to the mean of the world's population, is closest to Iranians, with similar trend to the neighboring countries, and appears to be intermediate between eastern (Asian) and western European (Caucasian) data.

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