ABSTRACT
La enfermedad por arañazo de gato (EAG) ha sido reconocida con frecuencia creciente en nuestro medio. Si bien se presenta habitualmente como un cuadro benigno y autolimitado, 5 a 25 por ciento de los casos pueden presentar complicaciones sistémicas que incluyen, entre otras, manifestaciones viscerales, cutáneas y óseas. Debido al inusual compromiso óseo descrito en la literatura, consideramos de interés presentar un caso clínico de una osteomielitis costovertebral asociada a ESG y discutir el eventual beneficio de la terapia antibacteriana en esta enfermedad
Subject(s)
Humans , Male , Child , Cat-Scratch Disease/complications , Osteomyelitis/etiology , Bartonella henselae/drug effects , Bartonella henselae/pathogenicity , Cat-Scratch Disease/diagnosis , Cat-Scratch Disease/drug therapy , Cat-Scratch Disease/etiology , Drug Therapy, Combination/therapeutic use , Osteomyelitis/diagnosis , RibsABSTRACT
La enfermedad por arañazo de gato (EAG) es una enfermedad infecciosa aguda benigna relativamente común, causada por Bartonella henselae. De los casos descritos sólo una pequeña proporción presenta compromiso extra nodal. Presentamos dos casos, una niña de 9 añosy un niño de 10 años. con EAG complicada por compromiso osteomielítico múltiple en vertebras, esternón, cráneo, pelvis y absceso paravertebral esplénico y linfadenopatía en uno de ellos, e importante compromiso vertebral con destrucción ósea en el otro. Se trataron con claritromicina y rifampicina en un caso, sólo con claritromicina en el otro. Ambos evolucionaron en mut buena forma con rápida mejoría clínica, radiológica y cintigráfica. Se analizan los casos y el manejo basado en la literatura publicada sobre EAG y esta inhabitual presentación con compromisos osteovertebrales múltiples
Subject(s)
Humans , Male , Female , Abscess/etiology , Cat-Scratch Disease/complications , Lymphatic Diseases/etiology , Osteomyelitis/etiology , Bartonella henselae/drug effects , Bartonella henselae/pathogenicity , Cat-Scratch Disease/diagnosis , Cat-Scratch Disease/drug therapy , Cat-Scratch Disease/etiology , Clarithromycin/therapeutic use , Rifampin/therapeutic use , Scoliosis/etiologyABSTRACT
Baccilary angiomatosis has recently been described as a disease that can spread systematically and that is potentially fatal. It is caused by Bartonella henselae and B. quintana, and presents as especially pronounced signs and symptoms in patients suffering from acquired immunodeficiency syndrome (AIDS). To clarify the pathogenesis of the disease and to try to define the relationships among baccilary angiomatosis, cat scratch disease and Carrión's bartonellosis, the authors of this study have attempted to develop an experimental model using mice that were immunocompetent as well as those that had their cellular immunity genetically compromised. A know concentration of B. henselae was inoculated intradermally in Balb/c an isogenic mice or an athymic group of the same lineage. Blood samples were taken on days-0, 3, 7, 10, 14, 28, and 60 after inoculation for indirect immunofluorescence antibody testing. On the 21st and 60th day, one animal from each group was sacrificed and a post mortem carried out including histological evaluation of the liver, spleen, lymph nodes, skin and other organs. Hemocultures of the sacrificed animals were collected. All results of serologic response, cultures and histologic examination were negative. The authors discuss the methodology, especially the use of isogenic animals of the same lineage in B. henselae infection, with and without immunodeficiency, and the resources for the negative results of histopathology, serology and cultures.
Subject(s)
Mice , Angiomatosis, Bacillary , Bartonella henselae , Bartonella quintana , Cat-Scratch Disease/etiology , Acquired Immunodeficiency Syndrome/complications , Mice, Inbred BALB C/immunology , Disease Models, Animal , Bartonella Infections/etiology , Rats, NudeABSTRACT
Os autores apresentam um caso de pacientre com neuro-retinite, retinite superficial e estrela macular, onde estabelecem o diagnóstico presumido de cat scratch disease. Comentam sobree outras formas de manifestaçäo retiniana da doença e sobre o tratamento.
Subject(s)
Adult , Female , Humans , Bartonella henselae/etiology , Cat-Scratch Disease/etiology , Macula Lutea/pathology , Optic Neuritis , Retinitis/complicationsABSTRACT
Numerosas afecciones son transmitidas al hombre por diferentes vectores, sean éstos insectos, pájaros o mamíferos. Entre las transmitidas por estos últimos, en la presente revisión se abordaron: la enfermedad por mordedura de rata que es básicamente un cuadro febril agudo, intenso, de comienzo brusco y de evolución recurrente y la enfermedad por rasguño de gato que se manifiesta por adenopatías sin signos inflamatorios locales, de lenta evolución regresiva y con escasa repercusión sobre el estado general. Ambas afecciones son más comunes en nuestro medio de lo que habitualmente se piensa y responden favorablemente a diversos antibióticos pero inicialmente plantean, con frecuencia, problemas de diagnóstico diferencial con enfermedades de pronóstico más grave
Subject(s)
Humans , Cat-Scratch Disease/diagnosis , Rat-Bite Fever/diagnosis , Anti-Bacterial Agents/therapeutic use , Cat-Scratch Disease/drug therapy , Cat-Scratch Disease/etiology , Diagnosis, Differential , Prognosis , Rat-Bite Fever/drug therapy , Rat-Bite Fever/etiology , Spirillum/pathogenicity , Streptobacillus/pathogenicitySubject(s)
Humans , Animals , Infant, Newborn , Infant , Child, Preschool , Child , Cats , Adult , Adolescent , Pediatrics , Zoonoses , Cat-Scratch Disease , Gram-Negative Bacterial Infections , Diagnosis, Differential , Cat-Scratch Disease/complications , Cat-Scratch Disease/diagnosis , Cat-Scratch Disease/epidemiology , Cat-Scratch Disease/etiology , Cat-Scratch Disease/therapy , Cat-Scratch Disease/transmissionABSTRACT
Os autores relatam um caso de Sindrome de Parinaud (conjuntivite com adenite satelite pre-auricular) causada por Bartonella henselae, o agente etiologico deste caso foi feito atraves da reacao de imunofluorescencia indireta o que permitiu um adequado enfoque terapeutico e acompanhamento do paciente, evitando o uso de antibioticos inadequados e intervencoes cirurgicas
Subject(s)
Humans , Child , Bartonella henselae/pathogenicity , Conjunctivitis/etiology , Fluorescent Antibody Technique/methods , Bartonella henselae/isolation & purification , Cat-Scratch Disease/etiologyABSTRACT
OBJECTIVE: To study the etiology and seroepidemiology of cat-scratch disease (CSD) in Hawaii. METHODS: Blood and fine-needle aspirate (FNA) from the lymph nodes of 39 consecutive patients with clinical CSD were cultured for Bartonella henselae, and blood samples from index cats, stray cats, and dogs were cultured and their sera were tested by indirect fluorescence antibody test for antibodies to B. henselae and Afipia felis. Sera from age- and sex-matched human subjects without cat exposure served as controls. RESULTS: Warthin-Starry staining showed positive results in only 4 of 32 FNAs, and B. henselae was isolated from only one FNA specimen. All of 38 patients who had two or more sera tested had elevated titers of antibody to B. henselae. Only 1 of 48 human control sera had antibody to B. henselae. Of 31 kittens, 21 had positive blood culture results and elevated antibody titers to B. henselae. Of three adult cats, all had negative blood culture results, but they had serologic evidence of past infection. Of 23 adult stray cats, 18 had elevated titers of antibody to B. henselae, but in only one was the blood culture result positive. Results of IFA tests were marginally positive for A. felis in 1 of 29 patients with CSD and in one adult stray cat and one dog. CONCLUSIONS: This study shows that the B. henselae IFA test is both highly sensitive and specific for the detection of infection caused by B. henselae and for the laboratory diagnosis of CSD, and that FNA is seldom helpful in confirming the diagnosis. We further demonstrated that CSD in Hawaii is due to B. henselae and that infection is directly linked to the scratch or bite of a kitten. Older cats seldom have bacteremia but often have serologic evidence of past infection. Our study fails to implicate dogs in the epidemiology of CSD in Hawaii, and A. felis was not etiologically implicated in CSD in the human subjects and animals we studied.
Subject(s)
Cat-Scratch Disease/epidemiology , Cat-Scratch Disease/etiology , Adolescent , Adult , Animals , Bartonella/immunology , Bartonella/isolation & purification , Cat-Scratch Disease/blood , Cats , Child , Child, Preschool , Dogs , Female , Fluorescent Antibody Technique , Hawaii/epidemiology , Humans , Immunoglobulin G/immunology , Incidence , Infant , Male , Prospective Studies , Seroepidemiologic StudiesABSTRACT
Descriçäo de um caso de doença da arranhadura de gato ou linforreticulose benigna, que envolve gânglios linfáticos que drenam os sítios dérmicos ou conjuntivais primários de inoculaçäo. A doença é autolimitada e benigna, mas pode, por vezes, progredir para infecçäo sistêmica grave e recorrente com encefalite, neuroretinite e osteomielite. Seu agente etiológico é a Rochalimaea benselae, um bacilo Gram-negativo pleomórfico de pequenas dimensöes, membro do subgrupo a-2 das a - proteobactérias