ABSTRACT
Condrossarcoma mesenquimal extraesquelético (CME) é um neoplasma maligno e raro em animais domésticos. Descreve-se um caso de CME em uma gata que apresentava uma massa firme, branco-amarelada, medindo 18cm de diâmetro, aderida à musculatura do membro pélvico esquerdo. O exame citológico revelou presença de células fusiformes individualizadas pleomórficas e agregados de pequenas células ovais, sem bordas definidas em meio à matriz intercelular amorfa. Devido à impossibilidade de tratamento e ao prognóstico desfavorável, foi realizada eutanásia. Microscopicamente foram observadas células fusiformes indiferenciadas e agregados de células condroides pleomórficas. O diagnóstico de CME foi confirmado pelas técnicas de azul alciano, tricrômico de Masson e pela prova imunoistoquímica, utilizando-se anticorpos antivimentina...
Extraskeletal mesenchymal chondrosarcoma (EMC) is a rare malignant tumor in domestic animals. We described a case of EMC in a cat with a mass measuring 18cm in diameter, yellowish-white and firm attached to the muscles in left hind limb. Cytological examination revealed the presence of individual pleomorphic spindle cells and clusters of small oval cells with no hard edges in the midst of an amorphous intercellular matrix. Due to the impossibility of treatment and poor prognosis, the cat was euthanized. Microscopically undifferentiated spindle cells and clusters of pleomorphic chondroid cells were observed. The CME diagnosis was confirmed with thealcian blue, Masson's trichrome and immunohistochemistry techniques, using antivimentin antibodies...
Subject(s)
Animals , Cats , Cats , Chondrosarcoma, Mesenchymal/diagnosis , Chondrosarcoma, Mesenchymal/veterinary , Kinesthesis , Motor Skills Disorders , ProprioceptionABSTRACT
Condrossarcoma mesenquimal extraesquelético (CME) é um neoplasma maligno e raro em animais domésticos. Descreve-se um caso de CME em uma gata que apresentava uma massa firme, branco-amarelada, medindo 18cm de diâmetro, aderida à musculatura do membro pélvico esquerdo. O exame citológico revelou presença de células fusiformes individualizadas pleomórficas e agregados de pequenas células ovais, sem bordas definidas em meio à matriz intercelular amorfa. Devido à impossibilidade de tratamento e ao prognóstico desfavorável, foi realizada eutanásia. Microscopicamente foram observadas células fusiformes indiferenciadas e agregados de células condroides pleomórficas. O diagnóstico de CME foi confirmado pelas técnicas de azul alciano, tricrômico de Masson e pela prova imunoistoquímica, utilizando-se anticorpos antivimentina.(AU)
Extraskeletal mesenchymal chondrosarcoma (EMC) is a rare malignant tumor in domestic animals. We described a case of EMC in a cat with a mass measuring 18cm in diameter, yellowish-white and firm attached to the muscles in left hind limb. Cytological examination revealed the presence of individual pleomorphic spindle cells and clusters of small oval cells with no hard edges in the midst of an amorphous intercellular matrix. Due to the impossibility of treatment and poor prognosis, the cat was euthanized. Microscopically undifferentiated spindle cells and clusters of pleomorphic chondroid cells were observed. The CME diagnosis was confirmed with thealcian blue, Masson's trichrome and immunohistochemistry techniques, using antivimentin antibodies.(AU)
Subject(s)
Animals , Cats , Cats , Chondrosarcoma, Mesenchymal/veterinary , Chondrosarcoma, Mesenchymal/diagnosis , Proprioception , Kinesthesis , Motor Skills DisordersABSTRACT
BACKGROUND: Mesenchymal chondrosarcoma (MC) is a subtype of chondrosarcoma, with an incidence varying from 1 to 8% of all chondrosarcomas. It is an aggressive neoplasm with a high tendency for late recurrence and occasional delayed distant metastasis. Orbital MC is very rare, and only approximately 30 cases have been described in the literature. We describe here one case of primary orbital MC. CASE REPORT: A 14-year-old boy without a past medical history presented with a 1-month history of progressive proptosis on the right eye. Computed tomography (CT) scans of the orbit revealed a right intraconic lesion, with areas of calcification. The lesion was excised. Histopathological analysis revealed that the tumor had a biphasic pattern, showing a combination of small cell malignancy and well-differentiated cartilage. Immunohistochemistry examination revealed a diffuse membrane expression of CD99 on the small cell malignancy; S-100 was positive only within the cartilage component. The patient received chemotherapy, and no metastatic disease was found at the 2-month follow-up. CONCLUSION: Although rare, MC should be considered in the differential diagnosis of a well-circumscribed orbital lesion in young adults, especially when CT scans reveal areas of calcification within the tumor.
Subject(s)
Chondrosarcoma, Mesenchymal/diagnosis , Orbital Neoplasms/diagnosis , 12E7 Antigen , Adolescent , Antigens, CD/analysis , Antigens, CD/biosynthesis , Calcinosis/diagnosis , Cartilage/metabolism , Cartilage/pathology , Cell Adhesion Molecules/analysis , Cell Adhesion Molecules/biosynthesis , Chondrosarcoma, Mesenchymal/metabolism , Chondrosarcoma, Mesenchymal/pathology , Chondrosarcoma, Mesenchymal/therapy , Diagnosis, Differential , Drug Therapy , Humans , Immunohistochemistry , Male , Mesenchymal Stem Cells/metabolism , Mesenchymal Stem Cells/pathology , Orbital Neoplasms/metabolism , Orbital Neoplasms/pathology , Orbital Neoplasms/therapy , S100 Proteins/analysis , S100 Proteins/biosynthesis , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
PURPOSE: To describe a patient with mesenchymal chondrosarcoma of the orbit, review clinical and imaging findings, and refine the differential diagnosis from other tumors of the orbit. METHODS: Interventional case report and literature review. RESULTS: A 21-year-old woman with a 6-month history of progressive proptosis presented with left-sided visual loss of recent onset. CT revealed a clearly outlined heterogeneous mass with calcified foci, whereas MRI showed an isointense signal to gray matter on T1- and T2-weighted images. The patient was diagnosed with mesenchymal chondrosarcoma of the orbit only after orbitotomy and subsequent histopathologic study. After surgery, she received adjuvant therapy with irradiation of the orbit. CONCLUSIONS: Mesenchymal chondrosarcoma is a rare malignant tumor of the orbit capable of mimicking several other lesions. Early diagnosis requires a high level of suspicion, particularly with regard to internally calcified lesions. The treatment of choice is complete surgical resection, or, when the tumor is not resectable or residual mass is present after surgery, chemotherapy and radiotherapy. Prognosis for patients with orbital mesenchymal chondrosarcoma is tentative at best, in part because of the rarity of the lesion.
Subject(s)
Chondrosarcoma, Mesenchymal/diagnosis , Orbital Neoplasms/diagnosis , Adult , Chondrosarcoma, Mesenchymal/radiotherapy , Chondrosarcoma, Mesenchymal/surgery , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Ophthalmologic Surgical Procedures/methods , Orbital Neoplasms/radiotherapy , Orbital Neoplasms/surgery , Radiotherapy, Adjuvant , Tomography, X-Ray ComputedABSTRACT
O presente relato descreve os achados clínico-patológicos de um condrossarcoma mesenquimal canino em um cão. Um cão macho, fila brasileiro de 13 anos de idade, mostrou, no físico, claudicação e aumento da massa tecidual do membro pélvico direito. Exame radiográfico tecidual foi realizada e revelou condroblastos neoplásicos. O proprietário decidiu não amputar o membro do animal e solicitou eutanásia. Completa necropsia e exame histológico foram realizados. A análise macroscópica mostrou proliferação tecidual neoplásica, originada da patela. Microscopicamente, a proliferação tecidual caracterizava-se pela coexistência de ilhas cartilaginosas, constituídas por células de variável maturidade e envoltas por células mesenquimais indiferenciadas. Este é o primeiro relato de condrossarcoma mesenquimal canino de origem patelar
The present report describes the clinicopathological findings of the mesenchymal chondrosarcoma in a dog. A 13-year-old male brazilian fila dog showed under physical examination, lameness and tissue mass increase of the right forelimb. Radiography revealed neoplasic chondroblasts. The owners decision was not th have dogs limb amputed and he required euthanasia. A complete necropsy and histological examinations was performed. The macroscopic examination showed neoplastic proliferations originated from the patella. Microscopically, the tissue proliferation was characterized by the coexistence of sharply demarcated cartilaginous islands of varied maturity and surrounding undifferentiated Mesenchymal cells. This is the first report of canine Mesenchymal chondrosacoma originated from the patella
Subject(s)
Animals , Dogs , Chondrosarcoma, Mesenchymal , Chondrosarcoma, Mesenchymal/diagnosis , Chondrosarcoma, Mesenchymal/pathology , Chondrosarcoma, Mesenchymal/veterinary , Chondrocytes , DogsABSTRACT
O presente relato descreve os achados clínico-patológicos de um condrossarcoma mesenquimal canino em um cão. Um cão macho, fila brasileiro de 13 anos de idade, mostrou, no físico, claudicação e aumento da massa tecidual do membro pélvico direito. Exame radiográfico tecidual foi realizada e revelou condroblastos neoplásicos. O proprietário decidiu não amputar o membro do animal e solicitou eutanásia. Completa necropsia e exame histológico foram realizados. A análise macroscópica mostrou proliferação tecidual neoplásica, originada da patela. Microscopicamente, a proliferação tecidual caracterizava-se pela coexistência de ilhas cartilaginosas, constituídas por células de variável maturidade e envoltas por células mesenquimais indiferenciadas. Este é o primeiro relato de condrossarcoma mesenquimal canino de origem patelar(AU)
The present report describes the clinicopathological findings of the mesenchymal chondrosarcoma in a dog. A 13-year-old male brazilian fila dog showed under physical examination, lameness and tissue mass increase of the right forelimb. Radiography revealed neoplasic chondroblasts. The owners decision was not th have dogs limb amputed and he required euthanasia. A complete necropsy and histological examinations was performed. The macroscopic examination showed neoplastic proliferations originated from the patella. Microscopically, the tissue proliferation was characterized by the coexistence of sharply demarcated cartilaginous islands of varied maturity and surrounding undifferentiated Mesenchymal cells. This is the first report of canine Mesenchymal chondrosacoma originated from the patella(AU)
Subject(s)
Animals , Dogs , Chondrocytes , Chondrosarcoma, Mesenchymal/diagnosis , Chondrosarcoma, Mesenchymal/pathology , Chondrosarcoma, Mesenchymal , Chondrosarcoma, Mesenchymal/veterinary , DogsABSTRACT
Presentamos tres casos de pacientes en los cuales se diagnosticaron tumores mesenquimales de diferente tipo, dos de ellos benignos y uno maligno. Las manifestaciones clínicas en cada caso fueron variables y el manejo en todos fue quirúrgico. Se revisa la literatura