ABSTRACT
BACKGROUND & AIMS: Gastrointestinal diseases account for considerable health care use and expenditures. We estimated the annual burden, costs, and research funding associated with gastrointestinal, liver, and pancreatic diseases in the United States. METHODS: We generated estimates using data from the National Ambulatory Medical Care Survey; National Hospital Ambulatory Medical Care Survey; Nationwide Emergency Department Sample; National Inpatient Sample; Kids' Inpatient Database; Nationwide Readmissions Database; Surveillance, Epidemiology, and End Results program; National Vital Statistics System; Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research; MarketScan Commercial Claims and Encounters data; MarketScan Medicare Supplemental data; United Network for Organ Sharing registry; Medical Expenditure Panel Survey; and National Institutes of Health (NIH). RESULTS: Gastrointestinal health care expenditures totaled $119.6 billion in 2018. Annually, there were more than 36.8 million ambulatory visits for gastrointestinal symptoms and 43.4 million ambulatory visits with a primary gastrointestinal diagnosis. Hospitalizations for a principal gastrointestinal diagnosis accounted for more than 3.8 million admissions, with 403,699 readmissions. A total of 22.2 million gastrointestinal endoscopies were performed, and 284,844 new gastrointestinal cancers were diagnosed. Gastrointestinal diseases and cancers caused 255,407 deaths. The NIH supported $3.1 billion (7.5% of the NIH budget) for gastrointestinal research in 2020. CONCLUSIONS: Gastrointestinal diseases are responsible for millions of health care encounters and hundreds of thousands of deaths that annually costs billions of dollars in the United States. To reduce the high burden of gastrointestinal diseases, focused clinical and public health efforts, supported by additional research funding, are warranted.
Subject(s)
Biomedical Research/economics , Gastrointestinal Diseases/economics , Health Expenditures/statistics & numerical data , Liver Diseases/economics , Pancreatic Diseases/economics , Ambulatory Care/economics , Ambulatory Care/statistics & numerical data , Cost of Illness , Digestive System Neoplasms/economics , Digestive System Neoplasms/epidemiology , Endoscopy, Digestive System/economics , Endoscopy, Digestive System/statistics & numerical data , Gastrointestinal Diseases/epidemiology , Hospitalization/economics , Hospitalization/statistics & numerical data , Humans , Liver Diseases/epidemiology , National Institutes of Health (U.S.) , Pancreatic Diseases/epidemiology , Patient Readmission/economics , Patient Readmission/statistics & numerical data , United States/epidemiologyABSTRACT
BACKGROUND: Hepatopancreatobiliary (HPB) and gastric oncologic operations are frequently performed at referral centers. Postoperatively, many patients experience care fragmentation, including readmission to "outside hospitals" (OSH), which is associated with increased mortality. Little is known about patient-level and hospital-level variables associated with this mortality difference. STUDY DESIGN: Patients undergoing HPB or gastric oncologic surgery were identified from select states within the Healthcare Cost and Utilization Project database (2006-2014). Follow-up was 90 days after discharge. Analyses used Kruskal-Wallis test, Youden index, and multilevel modeling at the hospital level. RESULTS: There were 7,536 patients readmitted within 90 days of HPB or gastric oncologic surgery to 636 hospitals; 28% of readmissions (n = 2,123) were to an OSH, where 90-day readmission mortality was significantly higher: 8.0% vs 5.4% (p < 0.01). Patients readmitted to an OSH lived farther from the index surgical hospital (median 24 miles vs 10 miles; p < 0.01) and were readmitted later (median 25 days after discharge vs 12; p < 0.01). These variables were not associated with readmission mortality. Surgical complications managed at an OSH were associated with greater readmission mortality: 8.4% vs 5.7% (p < 0.01). Hospitals with <100 annual HPB and gastric operations for benign or malignant indications had higher readmission mortality (6.4% vs 4.7%, p = 0.01), although this was not significant after risk-adjustment (p = 0.226). CONCLUSIONS: For readmissions after HPB and gastric oncologic surgery, travel distance and timing are major determinants of care fragmentation. However, these variables are not associated with mortality, nor is annual hospital surgical volume after risk-adjustment. This information could be used to determine safe sites of care for readmissions after HPB and gastric surgery. Further analysis is needed to explore the relationship between complications, the site of care, and readmission mortality.
Subject(s)
Continuity of Patient Care/organization & administration , Digestive System Neoplasms/therapy , Digestive System Surgical Procedures/adverse effects , Patient Readmission/statistics & numerical data , Postoperative Complications/epidemiology , Aged , Chemotherapy, Adjuvant/economics , Chemotherapy, Adjuvant/statistics & numerical data , Continuity of Patient Care/economics , Continuity of Patient Care/statistics & numerical data , Databases, Factual/statistics & numerical data , Digestive System Neoplasms/economics , Digestive System Neoplasms/mortality , Digestive System Surgical Procedures/economics , Digestive System Surgical Procedures/statistics & numerical data , Female , Health Care Costs/statistics & numerical data , Hospital Mortality , Humans , Male , Middle Aged , Patient Acceptance of Health Care/statistics & numerical data , Patient Readmission/economics , Postoperative Complications/economics , Postoperative Complications/etiology , Radiotherapy, Adjuvant/economics , Radiotherapy, Adjuvant/statistics & numerical data , Retrospective Studies , Risk Assessment/statistics & numerical data , Risk Factors , Tertiary Care Centers/economics , Tertiary Care Centers/organization & administration , Tertiary Care Centers/statistics & numerical data , Time FactorsABSTRACT
AIM: Many studies have reported close relationships between oral and systemic health. We explored the association of the number of remaining teeth with medical costs and hospitalization duration in people aged 75 and 80 years. METHODS: Oral health examinations were carried out at dental clinics in 2014. Medical cost and hospitalization duration data for fiscal year 2015 were obtained from the Mie Prefecture health insurer. We analyzed the data of 4700 individuals who met our inclusion criteria: 2745 75-year-olds and 1955 80-year-olds. The effects of remaining tooth numbers on medical costs and hospitalization days were analyzed using a generalized linear model with log link adjustment for confounders. RESULTS: Total medical costs for all diseases were significantly higher in those with 20-27, 10-19 and 1-9 teeth, and in edentulous older individuals, compared with those with 28 teeth. Outpatient medical costs for diabetes were significantly higher in those with 20-27 and 1-9 teeth. Inpatient medical costs for digestive cancers were significantly higher in those with 10-19 and 1-9 teeth, and in edentulous older individuals. Hospitalization for digestive cancer was significantly longer in those with 20-27, 10-19 and 1-9 teeth, and in edentulous older individuals, than in those with 28 teeth. The number of teeth as a continuous variable was significantly inversely associated with medical costs for cerebrovascular disease and digestive cancer, and hospitalization days for digestive cancer. CONCLUSION: Small numbers of teeth were associated with higher medical costs and longer hospital stays for older Japanese. Geriatr Gerontol Int 2019; 19: 335-341.
Subject(s)
Cerebrovascular Disorders , Digestive System Neoplasms , Health Care Costs/statistics & numerical data , Length of Stay , Mouth, Edentulous , Aged , Aged, 80 and over , Cerebrovascular Disorders/economics , Cerebrovascular Disorders/epidemiology , Cerebrovascular Disorders/therapy , Correlation of Data , Digestive System Neoplasms/economics , Digestive System Neoplasms/epidemiology , Digestive System Neoplasms/therapy , Female , Humans , Inpatients/statistics & numerical data , Japan/epidemiology , Length of Stay/economics , Length of Stay/statistics & numerical data , Male , Mouth, Edentulous/diagnosis , Mouth, Edentulous/epidemiology , Oral Health/economics , Oral Health/statistics & numerical data , Risk FactorsABSTRACT
BACKGROUND: Rising healthcare costs have led to increased focus on the need to achieve a higher "value of care." As value-maximization efforts expand to include more complex surgical patients, evidence to support meaningful implementation of complication-based initiatives is lacking. The objective of this study was to compare incremental costs of complications following major gastrointestinal (GI) resections for organ-specific malignant neoplasia using nationally representative data. METHODS: National (Nationwide) Inpatient Sample data, 2001-2014, were queried for adult (≥ 18 years) patients undergoing major resections for malignant neoplasia. Based on system-based complications considered relevant to the long-term treatment of GI disease, stratified differences in risk-adjusted incremental hospital costs and complication probabilities were compared. Differences in surgical outcomes and costs over time were also assessed. RESULTS: A total of 293,967 patients were included, weighted to represent 1,408,117 patients nationwide. One fourth (26.1%; 95% CI, 25.7-26.4%) experienced ≥ 1 pre-discharge complication (range, 45.3% esophagectomy to 24.0% rectal resection). Resultant annual risk-adjusted incremental hospital costs totaled $540 million nationwide (19.5% of the overall cost of care and an average of $20,900 per patient). Costs varied substantially with both cancer/resection type and complication group, ranging from $76.7 million for colectomies with infectious complications to $0.2 million for rectal resections with urinary complications. For each resection type, infectious ($154.7 million), GI ($85.5 million), and pulmonary ($77.9 million) complications were among the most significant drivers of increased hospital cost. CONCLUSIONS: Quantifying and comparing the impact of complications on an indication-specific level in more complex patients offers an important step toward allowing providers/payers to meaningfully prioritize the design of novel and adaptation of existing value-maximization approaches.
Subject(s)
Digestive System Neoplasms/economics , Digestive System Neoplasms/surgery , Digestive System Surgical Procedures/adverse effects , Hospital Costs/statistics & numerical data , Postoperative Complications/economics , Adolescent , Adult , Aged , Aged, 80 and over , Databases, Factual , Digestive System Neoplasms/pathology , Female , Gastrointestinal Diseases/economics , Gastrointestinal Diseases/etiology , Humans , Infections/economics , Infections/etiology , Lung Diseases/economics , Lung Diseases/etiology , Male , Middle Aged , Postoperative Complications/etiology , Risk Adjustment , United States , Young AdultABSTRACT
AIMS: Fluorescence in situ hybridisation (FISH) increases the sensitivity for detecting pancreatobiliary tract cancer over routine cytology. In this study, diagnostic accuracy and costs of cytology and FISH in detecting cancer in patients with jaundice with biliary strictures were assessed. METHODS: Brushing specimens from 109 patients with jaundice were obtained during endoscopic retrograde cholangiopancreatography and examined by cytology and FISH. The specimens were considered FISH-positive for malignancy if at least five polysomic cells or 10 cells with homozygous or heterozygous 9p21/p16 deletion were detected. Definitive diagnosis of the stricture as benign or malignant relied on surgical pathology (45 cases) or clinical-radiological follow-up >18â months (64 cases). We calculated costs of cytology and FISH based on the reimbursement from the Piedmont region, Italy (respectively, 33 and 750). RESULTS: Ninety of 109 patients had evidence of malignancy (44 pancreatic carcinomas, 36 cholangiocarcinomas, 5 gallbladder carcinomas, 5 other cancers), while 19 had benign strictures. Routine cytology showed 42% sensitivity, but 100% specificity for the diagnosis of malignancy, while FISH-polysomy showed 70% sensitivity with 100% specificity and FISH-polysomy plus homozygous or heterozygous 9p21/p16 deletion showed 76% sensitivity with 100% specificity. The cost per additional correct diagnosis of cancer obtained by FISH, in comparison with cytology, was 1775 using a sequential cytological approach (ie, performing FISH only in patients with negative or indeterminate cytology). CONCLUSIONS: FISH should be recommended as the second step in detecting cancer in patients with jaundice with pancreatobiliary tract strictures and cytology negative or indeterminate for malignancy.
Subject(s)
Biomarkers, Tumor/genetics , Cholestasis/etiology , Cytodiagnosis , Digestive System Neoplasms/complications , Digestive System Neoplasms/diagnosis , In Situ Hybridization, Fluorescence , Jaundice, Obstructive/etiology , Aged , Aged, 80 and over , Aneuploidy , Cholangiopancreatography, Endoscopic Retrograde , Cholestasis/diagnosis , Chromosome Deletion , Chromosomes, Human, Pair 16 , Chromosomes, Human, Pair 9 , Constriction, Pathologic , Cost-Benefit Analysis , Cytodiagnosis/economics , Digestive System Neoplasms/economics , Digestive System Neoplasms/genetics , Digestive System Neoplasms/pathology , Female , Genetic Predisposition to Disease , Health Care Costs , Heterozygote , Homozygote , Humans , In Situ Hybridization, Fluorescence/economics , Italy , Jaundice, Obstructive/diagnosis , Male , Middle Aged , Phenotype , Predictive Value of Tests , PrognosisABSTRACT
BACKGROUND/AIMS: This study aims to compare the clinical outcomes and costs between endoscopic biliary stenting (EBS) and percutaneous transhepatic biliary stenting (PTBS). METHODOLOGY: We randomly assigned 112 patients with unresectable malignant biliary obstruction 2006 and 2011 to receive EBS or PTBS with self-expandable metal stent (SEMS) as palliative treatment. PTBS was successfully performed in 55 patients who formed the PTBS group (failed in 2 patients). EBS was successfully performed in 52 patients who formed the EBS group (failed in 3 patients). The effectiveness of biliary drainage, hospital stay, complications, cost, survival time and mortality were compared. RESULTS: Patients in PTBS group had shorter hospital stay and lower initial and overall expense than the BBS group (P < 0.05). There was no significant difference in effectiveness of biliary drainage (P = 0.9357) or survival time between two groups (P = 0.6733). Early complications occurred in PTBS group was significantly lower than in EBS group (3/55 vs 11/52, P = 0.0343). Late complications in the EBS group did not differ significantly from PTBS group (7/55 vs 9/52, P = 0.6922). The survival curves in the two groups showed no significant difference (P = 0.5294). Conclusions: 3.
Subject(s)
Cholangiopancreatography, Endoscopic Retrograde/economics , Cholestasis/economics , Cholestasis/therapy , Digestive System Neoplasms/complications , Drainage/economics , Health Care Costs , Stents/economics , Adult , Aged , China , Cholangiopancreatography, Endoscopic Retrograde/adverse effects , Cholangiopancreatography, Endoscopic Retrograde/instrumentation , Cholangiopancreatography, Endoscopic Retrograde/mortality , Cholestasis/diagnosis , Cholestasis/etiology , Cholestasis/mortality , Cost-Benefit Analysis , Digestive System Neoplasms/economics , Digestive System Neoplasms/mortality , Drainage/adverse effects , Drainage/instrumentation , Drainage/mortality , Female , Humans , Kaplan-Meier Estimate , Length of Stay/economics , Male , Metals/economics , Middle Aged , Postoperative Complications/economics , Prosthesis Design , Time Factors , Treatment OutcomeABSTRACT
BACKGROUND AND AIM: With the rising incidence of digestive cancers in the Asia Pacific region and the advancement in diagnosis, management and palliation in these conditions, the clinical burden on oncologists is ever increasing. This Summit meeting was called to discuss the optimal management of digestive cancers and the role of Gastroenterologists. METHOD: Experts from Asia Pacific countries in the fields of medical, oncologic, surgical and endoscopic management of cancers in the esophagus, stomach, colon/rectum and the liver reviewed the literature and their practice. 18 position statements were drafted, debated and voted. RESULTS: It was agreed that the burden on GI cancer is increasing. More research will be warranted on chemotherapy, chemoprevention, cost-effectiveness of treatment and nutrition. Cancer management guidelines should be developed in this region when more clinical data are available. In order to improve care to patients, a multi-disciplinary team coordinated by a "cancer therapist" is proposed. This cancer therapist can be a gastroenterologist, a surgeon or any related discipline who have acquired core competence training. This training should include an attachment in a center-of-excellence in cancer management for no less than 12 months. CONCLUSION: The management of GI cancer should be an integrated multi-disciplinary approach and training for GI cancer therapists should be provided for.
Subject(s)
Digestive System Neoplasms/therapy , Gastroenterology/education , Medical Oncology/education , Patient Care Team/organization & administration , Physician's Role , Asia/epidemiology , Chemoprevention , Clinical Competence , Cost-Benefit Analysis , Diet , Digestive System Neoplasms/diagnosis , Digestive System Neoplasms/economics , Digestive System Neoplasms/epidemiology , Early Detection of Cancer , Education, Medical, Graduate , Hospitals, Special , Humans , Nutritional Support , Practice Guidelines as Topic , Precision Medicine , Randomized Controlled Trials as Topic , WorkloadABSTRACT
Antecedentes: la ultrasonografía endoscópica (USE) es una técnica de gran precisión para el estudio de diferentes patologías digestivas. El grado de conocimiento sobre el impacto de la USE en el tratamiento de estos pacientes es escaso. Objetivo: determinar el impacto terapéutico de la USE en una cohorte prospectiva de pacientes. Material y métodos: estudio que evalúa de forma prospectiva a todos los pacientes remitidos para USE en un periodo de 2 años. Se analiza: a) si la USE aporta información no conocida previamente; b) el impacto teórico de la USE en el tratamiento; c) el impacto final/real de USE en el tratamiento; d) la variación en la decisión terapéutica tras realizar la USE. Resultados: se incluyeron 700 pacientes. La indicación más frecuente de USE era el estudio preoperatorio de tumores digestivos. La USE aportó información nueva en el 89% de los casos. En opinión del ecoendoscopista estos hallazgos deberían suponer un cambio terapéutico en el 79% de los pacientes (impacto teórico). Sin embargo, el tratamiento sólo se modificó en el 67% de los casos (impacto real). La estrategia terapéutica post-USE fue menos agresiva en el 34% de los casos. Los cambios en la actitud terapéutica se asociaban con los hallazgos de USE, ingesta de alcohol y edad > 57 años. Conclusiones: Los hallazgos de la USE, la edad avanzada y el consumo de alcohol, se asocian con un cambio terapéutico en 2 de cada 3 pacientes remitidos a una unidad de USE. La decisión terapéutica final (post-USE) es menos agresiva en un tercio de estos pacientes, lo que podría representar un ahorro económico significativo(AU)
Antecedents: endoscopic ultrasonography (EUS) is a high accuracy technique for the study of many digestive diseases. The degree of knowledge about the impact of EUS on the management of these patients is inadequate. Aim: to determine the therapeutic impact of endoscopic ultrasonography (EUS) on a prospective cohort of patients. Methods: all patients referred for EUS over a period of 2 years were prospectively evaluated in order to asses: 1. EUS provides new information not previously known; 2. theoretic impact of EUS on patient management; 3. real impact of EUS on final therapy; 4. changes in the aggressiveness of the therapeutic decision after EUS. Results: 700 patients were included. Preoperative assessment of digestive tumors was the commonest indication. EUS provided new information in the 89% of the patients. With regard to endoscopist opinion, these findings should alter the management in 79% of patients (theoretic impact). However, EUS prompted a change in the management in 67% of patients (real impact). Final therapy post-EUS was less aggressive in 34% of patients. Changes in therapeutic decision were associated with EUS findings, alcohol intake and age >= 57 years old. Conclusions: 1) EUS findings, advanced age, and alcohol intake are associated with a change in the management in 2 out of every 3 patients referred for EUS. 2) Therapeutic decision (post- EUS) is less aggressive in a third of these patients, what should represent a significant economic saving(AU)
Subject(s)
Humans , Male , Female , Endosonography/methods , Endosonography , Cost Efficiency Analysis , Digestive System Neoplasms/economics , Digestive System Neoplasms/epidemiology , Digestive System Neoplasms , Cohort Studies , Prospective Studies , Gastrointestinal Tract/pathology , Gastrointestinal Tract , Upper Gastrointestinal Tract/pathology , Upper Gastrointestinal Tract , 28599 , Analysis of Variance , Confidence IntervalsABSTRACT
BACKGROUND: The traditional approach to palliating patients with malignant gastric outlet obstruction (GOO) has been open gastrojejunostomy (OGJ). More recently endoscopic stenting (ES) and laparoscopic gastrojejunostomy (LGJ) have been introduced as alternatives, and some studies have suggested improved outcomes with ES. The aim of this review is to compare ES with OGJ and LGJ in terms of clinical outcome. METHOD: A systematic literature search and review was performed for the period January 1990 to May 2008. Original comparative studies were included where ES was compared with either LGJ or OGJ or both, for the palliation of malignant GOO. RESULTS: Thirteen studies met the inclusion criteria (10 retrospective cohort studies, two randomised controlled trials and one prospective study). Compared with OGJ, ES resulted in an increased likelihood of tolerating an oral intake [odds ratio (OR) 2.6, p = 0.02], a shorter time to tolerating an oral intake (mean difference 6.9 days, p < 0.001) and a shorter post-procedural hospital stay (mean difference 11.8 days, p < 0.001). There were no significant differences between 30-day mortality, complication rates or survival. There were an inadequate number of cases to quantitatively compare ES with LGJ. CONCLUSION: This review demonstrates improved clinical outcomes with ES over OGJ for patients with malignant GOO. However, there is insufficient data to adequately compare ES with LGJ, which is the current standard for operative management. As these conclusions are based on observational studies only, future large well-designed randomised controlled trials (RCTs) would be required to ensure the estimates of the relative efficacy of these interventions are valid.
Subject(s)
Digestive System Neoplasms/complications , Gastric Bypass/methods , Gastric Outlet Obstruction/surgery , Palliative Care/methods , Digestive System Neoplasms/economics , Digestive System Neoplasms/mortality , Endoscopy, Gastrointestinal/economics , Endoscopy, Gastrointestinal/methods , Endoscopy, Gastrointestinal/statistics & numerical data , Gastric Bypass/economics , Gastric Bypass/statistics & numerical data , Gastric Outlet Obstruction/economics , Gastric Outlet Obstruction/etiology , Humans , Laparoscopy/economics , Laparoscopy/methods , Laparoscopy/statistics & numerical data , Length of Stay , Palliative Care/economics , Postoperative Complications/economics , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Prospective Studies , Randomized Controlled Trials as Topic , Recovery of Function , Retrospective Studies , Stents/economics , Stents/statistics & numerical data , Survival Analysis , Treatment OutcomeABSTRACT
BACKGROUND: Postoperative local water-filtered infrared A (wIRA) irradiation improves tissue oxygen partial pressure, tissue perfusion and tissue temperature, which are important in wound healing. METHODS: The effect of wIRA irradiation on abdominal wound healing following elective gastrointestinal surgery was evaluated. Some 111 patients undergoing moderate to major abdominal surgery were randomized into one of two groups: wIRA and visible light irradiation (wIRA group) or visible light irradiation alone (control group). Uncovered wounds were irradiated twice a day for 20 min from days 2-10 after operation. RESULTS: Irradiation with wIRA improved postoperative wound healing in comparison to visible light irradiation alone. Main variables of interest were: wound healing assessed on a visual analogue scale (VAS) by the surgeon (median 88.6 versus 78.5 respectively; P < 0.001) or patient (median 85.8 versus 81.0; P = 0.040), postoperative pain (median decrease in VAS score during irradiation 13.4 versus 0; P < 0.001), subcutaneous oxygen tension after irradiation (median 41.6 versus 30.2 mmHg; P < 0.001) and subcutaneous temperature after irradiation (median 38.9 versus 36.4 degrees C; P < 0.001). The overall result, in terms of wound healing, pain and cosmesis, measured on a VAS by the surgeon (median 79.0 versus 46.8; P < 0.001) or patient (79.0 versus 50.2; P < 0.001) was better after wIRA irradiation. CONCLUSION: Postoperative irradiation with wIRA can improve normal postoperative wound healing and may reduce costs in gastrointestinal surgery.
Subject(s)
Digestive System Neoplasms/surgery , Ultraviolet Therapy/methods , Wound Healing/radiation effects , Aged , Digestive System Neoplasms/economics , Double-Blind Method , Female , Humans , Male , Middle Aged , Postoperative Care/methods , Prospective Studies , Treatment OutcomeABSTRACT
Gastroduodenal outlet obstruction is a complication of advanced gastrointestinal malignant disease. In the past it was usually treated by an open surgical bypass procedure. During the last decade, endoscopic self-expandable stents (SEMS) have been used. The aim of this study was to compare these two palliative strategies concerning clinical outcome and health economy. A series of 36 patients with incurable malignant disease and gastroduodenal outlet obstruction syndrome were treated in a prospective study. According to the attending hospital and endoscopist on duty, 21 of the 36 patients were endoscopically treated with SEMS and 15 underwent an open surgical gastroenteroanastomosis. Health economic evaluation was based on the monetary charges for each patient associated with the procedure, postoperative care, and hospital stay. The hospital stay was 7.3 days for the stented group compared with 14.7 days for the open surgery group ( p > 0.05). The survivals were 76 and 99 days, respectively (NS). In the stented group all 15 patients (100%) alive after 1 month were able to eat or drink, and 11 (73%) of them tolerated solid food. In the surgical bypass group,9 out of 11 (81%) patients alive after 1 month could eat or drink, and 5 of them (45%) could eat solid food. The mean charges (U.S. dollars) during the hospital stay were $7215 for the stented group and $10,190 for the open surgery group ( p < 0.05). Palliation of the gastroduodenal obstruction in patients with malignant disease were at least as good, and the charges were lower for the endoscopic stenting procedure than for an open surgical bypass.
Subject(s)
Digestive System Neoplasms/surgery , Duodenoscopy/economics , Gastric Outlet Obstruction/surgery , Gastroenterostomy/economics , Palliative Care/economics , Stents/economics , Aged , Aged, 80 and over , Cost Savings/economics , Digestive System Neoplasms/economics , Digestive System Neoplasms/mortality , Female , Gastric Outlet Obstruction/economics , Gastric Outlet Obstruction/mortality , Hospital Charges/statistics & numerical data , Humans , Length of Stay/economics , Male , Middle Aged , Prospective Studies , Survival Rate , Sweden , Treatment OutcomeABSTRACT
We are now finding more malignancies in their early stages than previously. Attempts to ablate these lesions are difficult and do not provide the histological information required to decide on further treatment. Surgery is difficult to justify, as only a minority of lesions are associated with lymph node metastases and lesions may not become clinically relevant within the lifetime of an elderly patient. Endoscopic mucosal resection allows cancers to be resected at minimal cost, morbidity and mortality. It is also the most reliable investigation when assessing lesions which are suspicious for containing early cancer. After endoscopic removal, histological assessment of depth of penetration and a search for invasion into lymphatics or venules allows the risk of microscopic lymph node metastases to be predicted. The risk of developing metastatic disease can then be balanced against the risks of surgery in view of the patient's age and health.
Subject(s)
Digestive System Neoplasms/surgery , Endoscopy, Digestive System , Mucous Membrane/surgery , Biopsy , Coloring Agents , Digestive System Neoplasms/economics , Digestive System Neoplasms/mortality , Digestive System Neoplasms/pathology , Endoscopy, Digestive System/adverse effects , Endoscopy, Digestive System/economics , Endoscopy, Digestive System/mortality , Follow-Up Studies , Humans , Neoplasm InvasivenessABSTRACT
BACKGROUND: This study assesses the cost savings associated with using endoscopic ultrasound (EUS) before endoscopic retrograde cholangiopancreatography (ERCP) for evaluating patients with suspected obstructive jaundice. METHODS: One hundred forty-seven patients with obstructive jaundice of unknown or possibly neoplastic origin had EUS as their first endoscopic procedure. With knowledge of the final diagnosis and actual management for each patient, their probable evaluation and outcomes and their additional costs were reassessed assuming that ERCP would have been performed as the first endoscopic procedure. Also calculated were the additional costs incurred if EUS were unavailable for use after ERCP and had to be replaced by computed tomography or other procedures. RESULTS: The final diagnoses in these patients included malignancies (65%), choledocholithiasis or cholecystitis (18%), "medical jaundice" (11%), and miscellaneous benign conditions (6%). Fifty-four percent had EUS-guided fine-needle aspiration but only 53% required ERCP after EUS. An EUS-first approach saved an estimated $1007 to $1313/patient, but the cost was $2200 more if EUS was unavailable for use after ERCP. Significant savings persisted through sensitivity analysis. CONCLUSIONS: Performing EUS with EUS-guided fine-needle aspiration as the first endoscopic procedure in patients suspected to have obstructive jaundice can obviate the need for about 50% of ERCPs, helps direct subsequent therapeutic ERCP, and can substantially reduce costs in these patients.
Subject(s)
Biopsy, Needle/methods , Cholestasis/diagnostic imaging , Cholestasis/pathology , Endoscopy, Digestive System/methods , Adult , Algorithms , Cholangiopancreatography, Endoscopic Retrograde , Cholestasis/economics , Cost Savings , Cost-Benefit Analysis , Digestive System Neoplasms/diagnostic imaging , Digestive System Neoplasms/economics , Digestive System Neoplasms/pathology , Fees, Medical , Humans , UltrasonographyABSTRACT
This study investigates economic differentials in cancer survival in a sample of 1180 white men, focusing in particular on the relationship between income level and survivorship in the various subsites comprising the digestive system cancer category. Using the Cox proportional hazards model to control for confounding variables, the economic status-survivorship relationship is estimated for several subgroupings of primary malignancies. The results show significant variation in this relationship across different cancer sites, with a pronounced effect observed in carcinomas of the small intestine, peritoneum and, especially, colon and rectum. High-income patients with these malignancies had a significantly lower risk of dying from the disease (P less than 0.05) than either their middle- or lower-income counterparts, controlling for age, stage, and initial course of treatment. Differences in immunologic status, tumor characteristics, and follow-up treatment may account for these economic effects.