Subject(s)
Lymphoma, Large B-Cell, Diffuse/diagnosis , Paraneoplastic Endocrine Syndromes/etiology , Prolactin/blood , Uterine Cervical Neoplasms/diagnosis , Diagnosis, Differential , Female , Galactorrhea/complications , Humans , Infant , Lymphoma, Large B-Cell, Diffuse/complications , Uterine Cervical Neoplasms/complicationsABSTRACT
Acquired hypertrichosis lanuginosa is universally recognized as an individual disease and seldom reported as a genuine paraneoplastic manifestation. We report the case of a 30-year old woman with acquired hypertrichosis lanuginosa. Due to the finding of a cervical lymph node metastasis, she was investigated for an internal neoplasm, but the original tumour could not be found by the usual methods. A bronchogenic carcinoma was discovered at autopsy. Beside hypertrichosis, this patient had other disorders not described in the literature as associated with that disease, viz.: progressive systemic scleroderma, fissured and hyperpigmented tongue, thrombocytopenia, galactorrhoea, axillary and pubic alopecia and overcurvature of toe nails. A review of similar cases in the literature provided clinical arguments in favour of the hormonal origin of this paraneoplastic hypertrichosis.
Subject(s)
Carcinoma, Bronchogenic , Hypertrichosis/complications , Lung Neoplasms , Paraneoplastic Syndromes/complications , Scleroderma, Systemic/complications , Adult , Female , Galactorrhea/complications , Humans , Hypertrichosis/pathology , Thrombocytopenia/complications , Tongue Diseases/complicationsABSTRACT
In a prospective study performed between January, 1989 to August, 1988, we evaluated the association between hyperprolactinemia and its clinical features. Of the 58 subjects included: 23 had hyperprolactinemia and 35 were controls. The most frequent clinical manifestations in hyperprolactinemic patients were galactorrhea (43.4%) and amenorrhea (17.3%) amenorrhea-galactorrhea syndrome was found in only 8.6% cases with hyperprolactinemia. We found a statistically significant correlation (R = 0.66, p less than 0.01) between serum prolactin levels and clinical symptoms in hyperprolactinemic patients.
Subject(s)
Galactorrhea/complications , Hyperprolactinemia/complications , Adult , Amenorrhea/complications , Female , Humans , Prolactin/blood , Prospective Studies , Radioimmunoassay , Regression AnalysisABSTRACT
The medical history of 9 patients interested in childbearing are studied. They all had a high prolactin level, infertility, alteration in the menstrual cycle and in the majority (8/9) breast secretion. The results obtained with the usage of Parlodel (by the oral route) complemented with ovulation induction are evaluated, as well as existing local restrictions to permit fulfilling the various diagnostic procedures, oriented to define the etiology of the above mentioned clinical entity.
Subject(s)
Bromocriptine/therapeutic use , Galactorrhea/complications , Hyperprolactinemia/drug therapy , Infertility, Female/etiology , Menstruation Disturbances/complications , Female , Humans , Hyperprolactinemia/complications , Lactation DisordersABSTRACT
Se estudia la historia clínica de 9 pacientas interesadas en la procreación. Todas ellas presentaban un nivel de prolactina elevada, infertilidad conyugal y alteración en los ciclos menstruales; casi todas (8/9), perturbación en la lactopoyesis. Se evalúan los resultados obtenidos con el uso oral de Parlodel, complementado con inductores de la ovulación; y se menciona la restricción que existe en nuestro medio para realizar los diferentes procedimientos diagnósticos orientados a definir la etiología del cuadro clínico antes indicado
Subject(s)
Humans , Female , Hyperprolactinemia/drug therapy , Bromocriptine/therapeutic use , Galactorrhea/complications , Infertility, Female/diagnosis , Menstruation Disturbances/complications , Hyperprolactinemia/complications , Lactation DisordersABSTRACT
A hiperprolactemia é um dos sinais mais associados aos problemas de esterilidade feminina e de disfunçäo ovarianas, acarretando quadros de amenorréia, de anovulaçäo, de opsomenorréia e de ciclo eumenorréico com alteraçäo na fase lútea. Säo analisados 48 casos selecionados nas clínicas particulares dos autores, distribuídos de acordo com as drogas de prolactina. Há 11 casos de hiperprolactinemia por iatrogenismo. O sintoma mais constatado na hiperprolactinemia foi a anovulaçäo. Este achado esteve presente em 48% de todas as pacientes. O motivo mais freqüente da consulta foi a esterilidade primária, que respondeu por mais de 50% do contingente total, englobando amenorréia, opsomenorréia e ciclo eumenorréico. Em mais de 50% das vezes, o resultado da dosagem da prolactina esteve compreendido entre 26 e 55ng.ml de plasma. Apenas 27% das pacientes conseguiram engravidar, provavelmente pela associaçäo de outros fatores. Nem todas as mulheres com hiperprolactinemia säo portadoras de galactorréia. Em nossos casos ela foi detectada em 77% das pacientes. Amenorréia secundária deve sempre servir de motivaçäo para diagnosticar hiperprolactinemia. Foram analisadas as condutas clínicas e qualificadas as formas de tratamento à base de brommocriptina