Fibro-histiocitoma maligno retroperitoneal complicado por hemorragia espontânea intracavitária / Malignant fibrous histiocytoma of the retroperitoneum complicated by spontaneous hemorrhage into the cavity

Apresentamos um caso de fibro-histiocitoma maligno retroperitoneal complicado por hemorragia espontânea intracavitária, sendo esta uma forma de apresentaçäo muito atípica. Os fibro-hitiocitomas malignos säo tipos comuns de sarcoma, porém, a sua localizaçäo no retroperitônio, com invasäo da cavidade peritoneal a partir deste sítio primário, é muito rara. Como todos os tumores do retroperitônio, o diagnóstico precoce é difícil, poi suas apresentaçöes clínica, laboratorial e radiológica säo inespecíficas e näo permitem o diagnóstico definitivo. A paciente foi submetida a uma laparotomia de urgência, que foi diagnóstica e terapêutica. Os autores reportam este caso enfatizando o diagnóstico, tratamento e evoluçäo

Intraarterial chemotherapy with limb-sparing resection of large soft-tissue sarcomas of the extremities.

Fifteen patients with large (average, 15-cm), high-grade soft-tissue sarcomas of the extremities received prolonged selective intraarterial infusions of chemotherapeutic agents in an attempt to permit limb-sparing resection of these tumors, which would otherwise have required amputation. There were seven malignant fibrous histiocytomas, four liposarcomas, two fibrosarcomas, one leiomyosarcoma, and one rhabdomyosarcoma; 73% were grade III. Seven patients underwent two catheterizations, for a total of 22 infusions, which averaged 11.3 days each. There were four catheterization-related complications, including catheter occlusion or dislodgement in one patient each and two cases of arterial thromboembolism in patients in whom anticoagulant dose was not adequate. Both of the latter patients required thrombectomy; one developed gangrene, which precluded limb-sparing surgery. Thirteen of the 15 patients underwent limb-sparing resections, and two underwent amputations. No wound complications occurred. With a median follow-up of 36 months (mean, 34 months), life-table analysis indicates overall and disease-free survivals of 72% and 59%, respectively, at 2 years and 64% and 59% at 3 years. In comparison to other reported therapies, this technique permits limb salvage in most patients without the high wound complication rate associated with preoperative radiation therapy, with equivalent local disease control and survival.

Some new aryl-sydnones: effects on murine tumours.

The effects of new aryl-sydnones: 3-[4-X-3-nitrophenyl]-1,2,3-oxadiazolium-5-olates, where X = Cl (SYD-1); pyrrolidino (SYD-2); piperidino (SYD-3) and morpholino (SYD-4) on the survival of mice bearing Sarcoma 180, Ehrlich carcinoma, B10MCII (Fibrous histiocytoma) and L1210 leukemia ascitic tumours, on the proliferation of cultured tumour cells and on the synthesis of DNA in L1210 leukemia were determined. SYD-1 and SYD-2 in vivo significantly enhanced the survival of S180, Ehrilich and B10MCII tumour-bearing mice. Furthermore, SYD-2 showed significant activity against L1210. SYD-3 and SYD-4 did not show antitumour activity. SYD-1, in vitro was the most cytotoxic against all the above tumour cells. All of the drugs tested inhibited thymidine uptake by L1210 cells, SYD-4 being the least active.

Deficiência aguda de tiamina: efeitos no crescimento e resposta quimioterápica de um fibro-histiocitoma maligno de rato / Acute thiamine deficiency: effects on growth and response chemotherapy of a malignant fibrohistocytoma of rat

Os objetivos do presente trabalho foram estdar os efeitos da deficiência aguda de tiamina no crescimento e na resposta quimiterápica de um fibro-histiocitoma maligno no rato. Para tanto, ratos foram inoculados por via subcutânea com suspensäo de células tumorais e divididos em quadro grupos, de 10 animais cada: DCT - alimentados com dieta sem tiamina; TGT - alimentados com dieta controle; e TVC - alimentados com dieta controle e tratados com SVC. Os animais tratados com SVC (DVC e TVC) apresentaram diminuiçäo de volume tumoral quando comparados com os näo tratados (DCT e TCT). Entretanto, näo houve alteraçäo no volume tumoral de animais carentes em tiamina tratados (DVC) em relaçäo àqueles tratados e com dieta controle (DCT). Estes dados indicam que a deficiência aguda de tiamina per se näo altera o cresciento do FHM como também näo modifica a resposta de tumor frente à quimioterapia com SVC.

Angiomas palpebrales: su tratamiento con corticoides intralesionales / Palpebral angiomas: their treatment with intralesional corticosteroids

Los angiomas palpebrales con oclusión ocular parcial o total pueden producir secuelas irreversibles como la ampliopía, de ahí la importancia de su tratamiento precoz y agresivo. Los autores discuten los efectos terapéuticos de una asociación de Betametasona y Triamcinolona intralesional en los angiomas de 10 pacientes de sexo femenino, y los resultados obtenidos. la acción de la corticoterapia sobre el crecimiento de las niñas tratadas fue controlada a través de la determinación de la edad ósea y del ritmo de crecimiento

Angiomas palpebrales: su tratamiento con corticoides intralesionales / Palpebral angiomas: their treatment with intralesional corticosteroids

Los angiomas palpebrales con oclusión ocular parcial o total pueden producir secuelas irreversibles como la ampliopía, de ahí la importancia de su tratamiento precoz y agresivo. Los autores discuten los efectos terapéuticos de una asociación de Betametasona y Triamcinolona intralesional en los angiomas de 10 pacientes de sexo femenino, y los resultados obtenidos. la acción de la corticoterapia sobre el crecimiento de las niñas tratadas fue controlada a través de la determinación de la edad ósea y del ritmo de crecimiento (AU)