Subject(s)
Humans , Practice Guidelines as Topic , Diabetes Mellitus, Type 2/prevention & control , Argentina , Blood Glucose/analysis , Blood Glucose Self-Monitoring , Exercise , Evidence-Based Medicine/methods , Diabetes Mellitus, Type 2/diagnosis , Diabetes Mellitus, Type 2/drug therapy , GRADE Approach , Hyperglycemia/drug therapy , Hypoglycemia/diet therapy , Hypoglycemia/drug therapy , Insulin, Isophane/therapeutic use , Metformin/therapeutic useABSTRACT
We compared the effects of oral administration of high-dose or low-dose glutamine dipeptide (GDP), alanine (ALA), glutamine (GLN), and ALA + GLN on the blood availability of amino acids in rats submitted to insulin-induced hypoglycemia (IIH). Insulin detemir (1 U/kg) was intraperitoneally injected to produce IIH; this was followed by oral administration of GDP, GLN + ALA, GLN, or ALA. We observed higher blood levels of GLN, 30 min after oral administration of high-dose GDP (1000 mg/kg) than after administration of ALA (381 mg/kg) + GLN (619 mg/kg), GLN (619 mg/kg), or ALA (381 mg/kg). However, we did not observe the same differences after oral administration of low-dose GDP (100 mg/kg) compared with ALA (38.1 mg/kg) + GLN (61.9 mg/kg), GLN (61.9 mg/kg), or ALA (38.1 mg/kg). We also observed less liver catabolism of GDP compared to ALA and GLN. In conclusion, high-dose GDP promoted higher blood levels of GLN than oral ALA + GLN, GLN, or ALA. Moreover, the lower levels of liver catabolism of GDP, compared to ALA or GLN, contributed to the superior performance of high-dose GDP in terms of blood availability of GLN.
Subject(s)
Alanine/administration & dosage , Amino Acids/blood , Glutamine/administration & dosage , Hypoglycemia/chemically induced , Hypoglycemia/diet therapy , Liver/metabolism , Administration, Oral , Animals , Dietary Supplements , Dipeptides/administration & dosage , Insulin/administration & dosage , Insulin/pharmacology , Liver/drug effects , Male , Rats , Rats, WistarSubject(s)
Glucose/therapeutic use , Hypoglycemia/diet therapy , Insulinoma/diet therapy , Insulinoma/surgery , Pancreatic Neoplasms/diet therapy , Pancreatic Neoplasms/surgery , Snacks , Humans , Hypoglycemia/blood , Hypoglycemia/etiology , Insulin/blood , Insulinoma/blood , Male , Mexico , Pancreatic Neoplasms/blood , Pancreatic Neoplasms/complications , Young AdultSubject(s)
Diabetes Mellitus, Type 1/diet therapy , Diabetes Mellitus, Type 1/physiopathology , Dietary Carbohydrates/administration & dosage , Exercise , Hypoglycemia/prevention & control , Adolescent , Blood Glucose , Diabetes Mellitus, Type 1/blood , Female , Humans , Hypoglycemia/blood , Hypoglycemia/diet therapy , Isotonic Solutions/administration & dosage , MaleSubject(s)
Circadian Rhythm , Diabetes Mellitus, Type 1/blood , Hypoglycemia/etiology , Child , Diabetes Mellitus, Type 1/drug therapy , Feeding Behavior , Glycated Hemoglobin/analysis , Humans , Hyperinsulinism/etiology , Hyperinsulinism/prevention & control , Hypoglycemia/diet therapy , Hypoglycemia/prevention & control , Hypoglycemic Agents/administration & dosage , Hypoglycemic Agents/therapeutic use , Insulin/administration & dosage , Insulin/therapeutic use , Insulin, Isophane/administration & dosage , Insulin, Isophane/therapeutic useSubject(s)
Food, Formulated , Glycogen Storage Disease Type IV/diet therapy , Glycogen Storage Disease/diet therapy , Hepatomegaly/pathology , Hypoglycemia/diet therapy , Child, Preschool , Glycogen Storage Disease Type IV/complications , Hepatomegaly/physiopathology , Humans , Hypoglycemia/etiology , Hypoglycemia/prevention & control , Infant , Liver Function Tests , MaleABSTRACT
Se comunica el caso de un lactante de 3 meses de edad que presenta signos clínicos y de laboratorio correspondientes a un cuadro de hipoglicemia, el que se inicia poco después de comenzar a ingerir leche total. Hospitalizado, sufre una diarrea grave que obliga al uso de soluciones glucosalinas por vía endovenosa y posteriormente leche de soya, con lo que los episodios hipoglicémicos desaparecen. Al introducir en su dieta carne de vacuno vuelven a presentar-se las manifestaciones de hipoglicemia. Sospechado el diagnóstico de sensibilidad a la leucina, que se confirma con un test de tolerancia a ese amnioácido, se instala una dieta pobre en leucina. Controlado a los 21 meses de vida, el examen neurológico , el desarrollo psicomotor y pondoestatual son normales