ABSTRACT
Tuberculosis is a fairly common disease in the United States and around the world, newly infecting ten million people throughout the world per year. Despite the pervasiveness of tuberculosis, cutaneous tuberculosis (CTB) rarely manifests worldwide. Tuberculous infections of the skin arise in several distinct variants that can be classified as either multibacillary or paucibacillary; each subtype within these categories presents with its own morphological and histological findings. The diagnosis of CTB can prove clinically challenging as its variants mimic many conditions dermatologist encounter on a daily basis. Additionally, tissue confirmation is difficult. We report a case of CTB which evolved from a lupus vulgaris presentation to the metastatic tuberculous abscess variant.
Subject(s)
Skin/pathology , Tuberculosis, Cutaneous/diagnosis , Aged , Biopsy , Diagnosis, Differential , Disease Progression , Female , Humans , Lupus Vulgaris/complications , Lymphoma, Non-Hodgkin/complications , Mycobacterium/isolation & purification , Tuberculosis, Cutaneous/diagnostic imaging , Tuberculosis, Cutaneous/pathologyABSTRACT
Cutaneous disease can present with lesions of all colors of the visible spectrum. Lesions of the skin, nail, and mucous membranes with an orange color can be due to a variety of etiologies. The conditions may appear as purely orange, yellow-orange, red-orange, tan, or brown with an orange hue. The orange color may also present as a transient phase of a disease process. As with all dermatologic pathology, a key way to distinguish orange-colored lesions is by distribution and morphology. The sclera, palate, lips, gingiva, and nails may also be involved. A literature review using PubMed with keywords, including orange, skin, mucosa, cutaneous, xanthoderma, and granuloma, was conducted to gather all dermatologic conditions that can present with an orange color. The relevant diseases were categorized by etiology and include inflammatory, infectious, neoplastic, and exogenous causes.
Subject(s)
Pigmentation Disorders/etiology , Sebaceous Gland Neoplasms/complications , Color , Histiocytosis, Non-Langerhans-Cell/complications , Humans , Leishmaniasis, Cutaneous/complications , Lupus Vulgaris/complications , Mastocytoma/complications , Mastocytoma, Skin/complications , Mouth Mucosa , Pityriasis Rubra Pilaris/complications , Sarcoidosis/complicationsABSTRACT
Skin squamous cell carcinoma is the second most common non-melanoma skin tumor worldwide. Most skin squamous cell carcinoma patients have underlying diseases. Here, we report a 56â¯year-old patient diagnosed with skin squamous cell carcinoma and with a 30â¯year course of neglected lupus vulgaris, which was very rare. In this case, we adopted a treatment strategy involving a small wound: superficial resection combined with photodynamic therapy with a satisfied result.
Subject(s)
Carcinoma, Squamous Cell/therapy , Face , Lupus Vulgaris/therapy , Photochemotherapy/methods , Skin Neoplasms/therapy , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/drug therapy , Carcinoma, Squamous Cell/surgery , Female , Humans , Lupus Vulgaris/complications , Lupus Vulgaris/drug therapy , Lupus Vulgaris/surgery , Middle Aged , Skin Neoplasms/complications , Skin Neoplasms/drug therapy , Skin Neoplasms/surgerySubject(s)
Conjunctiva/pathology , Lupus Vulgaris/complications , Lupus Vulgaris/diagnosis , Adolescent , Female , HumansABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Granuloma/complications , Granuloma/diagnosis , Granuloma/drug therapy , Adrenal Cortex Hormones/therapeutic use , Betamethasone Valerate/therapeutic use , Mammography/methods , Cefuroxime/therapeutic use , Erythema/complications , Erythema/drug therapy , Breast Neoplasms , Diagnosis, Differential , Hidradenitis/complications , Hidradenitis/epidemiology , Lupus Vulgaris/complications , Acanthosis Nigricans/complications , Acanthosis Nigricans/pathologyABSTRACT
La tuberculosis continúa siendo, en la actualidad, una enfermedad frecuente en nuestro medio debido principalmente a dos factores, la inmigración y la coinfección con el virus de la inmunodeficiencia humana. La afectación cutánea por Mycobacterium tuberculosis es muy poco habitual y, concretamente, la forma periorificial o ulcerosa, que se asocia a tuberculosis pulmonar extensa, es excepcional. Sin embargo, su incidencia puede aumentar en el futuro debido a los factores anteriormente citados junto a la inmunodepresión asociada al envejecimiento de la población y a los tratamientos inmunosupresores, por lo que se hace imprescindible incluir dicha enfermedad en el diagnóstico diferencial de las lesiones cutáneas en pacientes con tuberculosis pulmonar. Su diagnóstico requiere el aislamiento en el cultivo o la positividad en la técnica de reacción en cadena de la polimerasa de M. tuberculosis, y su tratamiento es el mismo que el de la tuberculosis pulmonar
Tuberculosis remains today a common disease in our daily lives mainly due to two causes, immigration and coinfection with the human immunodeficiency virus. Skin involvement by Mycobacterium tuberculosis is highly unusual, and particularly periorificial or ulcer form, which is associated with extensive pulmonary tuberculosis, is uncommon. However, its appearance may increase in the future due to the causes mentioned above, as well as immunosuppression associated with an aging population, and immunosuppressive treatments. Therefore, it is essential to include this disease in the differential diagnosis of skin lesions in patients with pulmonary tuberculosis. Diagnosis requires culture isolation or positivity of the M. tuberculosis polymerase chain reaction technique. Its treatment is the same as that of the pulmonary tuberculosis
Subject(s)
Adult , Humans , Male , Tuberculosis, Cutaneous/pathology , Tuberculosis, Pulmonary , Polymerase Chain Reaction/methods , Therapeutics/methods , Lupus Vulgaris/diagnosis , Tuberculosis, Cutaneous/metabolism , Tuberculosis, Pulmonary/transmission , Polymerase Chain Reaction/standards , Therapeutics/standards , Lupus Vulgaris/complicationsSubject(s)
Aminoquinolines/therapeutic use , Antineoplastic Agents/therapeutic use , Facial Dermatoses/drug therapy , Keratoacanthoma/drug therapy , Lupus Vulgaris/complications , Aged , Chemotherapy, Adjuvant , Facial Dermatoses/pathology , Humans , Imiquimod , Keratoacanthoma/pathology , Male , Treatment OutcomeABSTRACT
A small percentage of patients with tuberculosis present with cutaneous findings, which may be difficult to diagnose. We present a patient diagnosed with a rare, non-scarring form of cutaneous tuberculosis (CTB), classically termed as lupus vulgaris erythematoides.