Ethanol Ablation for Odontogenic myxoma: New alternative of conservative treatment

Odontogenic myxoma is a maxillofacial tumor that is benign in nature. It is characterized by a slow-growing, painless, and site-aggressive behavior. A main feature is that it is not encapsulated so it has high potential of invasiveness and penetration into peripheral tissues. Large lesions may cause extensive compromise of the region. Treatment strategy for Odontogenic Myxoma is still controversial. Radical resection with an appropriate surgical margin is recommended, but emerging evidence has suggested that a more conservative approach will result in less morbidity and adequate results. This report shows a remarkable result on a 16-year-old patient who had a Mandibular Odontogenic Myxoma treated with a conservative approach. Intra-lesional absolute alcohol irrigation was performed during a 5-month period. Considerable volume reduction of the lesion happened which allowed a minimal overall resection. No recurrence was found after a 3 year follow-up.

Mixoma odontogênico: relato de caso / Odontogenic myxoma: case related

Essa monografia trata-se de um relato de caso clínico de mixoma odontogênico. Para tanto, foi realizada inicialmente, uma revisão de literatura sobre o tema de modo a verificar as características, aspectos clínicos, imaginológicos, alternativas de tratamento e outros referentes a esta patologia. O conteúdo é importante de ser estudado, pois, o mixoma odontogênico dos maxilares é uma patologiabenigna, independente da etnia, sexo, localização, ou outro, apresentando características imaginológicas e clínicas muito variadas, fator que o tornauma importante patologia tumoral do sistema estomatognático

This monograph deals with a clinical case report of odontogenicmyxoma. A review of the literature on the subject was carried out initially to verify the characteristics, clinical aspects, imaging aspects, treatment studied, the odontogenicmyxoma of the maxillary is a benign pathology. The content is important to be studied, since the odontogenicmyxoma of the maxillary is a benign pathology, independent of ethnicity, sex, localization, or other, presenting very varied imaging and clinical characteristics, a factor that makes it an important tumor pathology of stomatognathic systemalternatives and others related to this pathology. The content is important to be

Cardiac myxoma in pregnancy: a comprehensive review / Mixoma cardíaco na gravidez: revisão abrangente

AbstractObjective:Cardiac myxoma in pregnancy is rare and the clinical characteristics of this entity have been insufficiently elucidated. This article aims to describe the treatment options and the risk factors responsible for the maternal and feto-neonatal prognoses.Methods:A comprehensive search of the literature of cardiac myxoma in pregnancy was conducted and 44 articles with 51 patients were included in the present review.Results:Transthoracic echocardiography was the most common diagnostic tool for the diagnosis of cardiac myxoma during pregnancy. Cardiac myxoma resection was performed in 95.9% (47/49); while no surgical resection was performed in 4.1% (2/49) patients (P=0.000). More patients had an isolated cardiac myxoma resection in comparison to those with a concurrent or staged additional cardiac operation [87.2% (41/47) vs. 12.8% (6/47), P=0.000]. A voluntary termination of the pregnancy was done in 7 (13.7%) cases. In the remaining 31 (60.8%) pregnant patients, cesarean section was the most common delivery mode representing 61.3% and vaginal delivery was more common accounting for 19.4%. Cardiac surgery was performed in the first, second and third trimester in 5 (13.9%), 14 (38.9%) and 17 (47.2%) patients, respectively. No patients died. In the delivery group, 20 (76.9%) neonates were event-free survivals, 4 (15.4%) were complicated and 2 (7.7%) died. Neonatal prognoses did not differ between the delivery modes, treatment options, timing of cardiac surgery and sequence of cardiac myxoma resection in relation to delivery.Conclusion:The diagnosis of cardiac myxoma in pregnancy is important. Surgical treatment of cardiac myxoma in the pregnant patients has brought about favorable maternal and feto-neonatal outcomes in the delivery group, which might be attributable to the shorter operation duration and non-emergency nature of the surgical intervention. Proper timing of cardiac surgery and improved cardiopulmonary bypass conditions may result in even better maternal and feto-neonatal survivals.

ResumoObjetivo:Mixoma cardíaco durante a gravidez é raro e as características clínicas dessa entidade não foram suficientemente esclarecidas. Este artigo tem como objetivo descrever as opções de tratamento e os fatores de risco responsáveis pelo prognóstico materno e fetal-neonatal.Métodos:Foi realizada uma pesquisa abrangente na literatura sobre mixoma cardíaco durante a gravidez e 44 artigos com 51 pacientes foram incluídos na presente revisão.Resultados:Ecocardiografia transtorácica foi a ferramenta de diagnóstico mais comum para o diagnóstico de mixoma cardíaco durante a gravidez. Ressecção do mixoma cardíaco foi realizada em 95,9% (47/49); enquanto não foi realizada ressecção cirúrgica em 4,1% (2/49) dos pacientes (P=0,000). Mais pacientes tiveram ressecção isolada do mixoma cardíaco em comparação com aqueles com operação cardíaca concomitante ou adicional [87,2% (41/47) vs. 12,8% (6/47), P=0,000]. A interrupção voluntária da gravidez foi feita em 7 (13,7%) casos. Nas restantes 31 (60,8%) pacientes grávidas, a cesariana foi o modo de parto mais comum, representando 61,3% e parto vaginal contabilizou 19,4%. A cirurgia cardíaca foi realizada no primeiro, segundo e terceiro trimestre em 5 (13,9%), 14 (38,9%) e 17 (47,2%) pacientes, respectivamente. Nenhuma paciente morreu. No grupo de parto, 20 (76,9%) recém-nascidos sobreviveram livres de eventos, 4 (15,4%) tiveram complicações e 2 (7,7%) morreram. Os prognósticos neonatais não diferiram entre os modos de parto, opções de tratamento, tempo de cirurgia cardíaca e sequência de ressecção mixoma cardíaco em relação ao parto.Conclusão:O diagnóstico de mixoma cardíaco durante a gravidez é importante. Tratamento cirúrgico de mixoma cardíaco em pacientes grávidas trouxe resultados favoráveis para as mães e os neonatos no grupo de parto, o que pode ser atribuído à duração mais curta da operação e à natureza não emergencial da intervenção cirúrgica. O momento adequado da cirurgia cardíaca e melhoria das condições de circulação extracorpórea podem resultar em sobrevivência materna e do feto-neonato ainda melhor.

Cardiac myxoma in pregnancy: a comprehensive review.

OBJECTIVE: Cardiac myxoma in pregnancy is rare and the clinical characteristics of this entity have been insufficiently elucidated. This article aims to describe the treatment options and the risk factors responsible for the maternal and feto-neonatal prognoses. METHODS: A comprehensive search of the literature of cardiac myxoma in pregnancy was conducted and 44 articles with 51 patients were included in the present review. RESULTS: Transthoracic echocardiography was the most common diagnostic tool for the diagnosis of cardiac myxoma during pregnancy. Cardiac myxoma resection was performed in 95.9% (47/49); while no surgical resection was performed in 4.1% (2/49) patients (P=0.000). More patients had an isolated cardiac myxoma resection in comparison to those with a concurrent or staged additional cardiac operation [87.2% (41/47) vs. 12.8% (6/47), P=0.000]. A voluntary termination of the pregnancy was done in 7 (13.7%) cases. In the remaining 31 (60.8%) pregnant patients, cesarean section was the most common delivery mode representing 61.3% and vaginal delivery was more common accounting for 19.4%. Cardiac surgery was performed in the first, second and third trimester in 5 (13.9%), 14 (38.9%) and 17 (47.2%) patients, respectively. No patients died. In the delivery group, 20 (76.9%) neonates were event-free survivals, 4 (15.4%) were complicated and 2 (7.7%) died. Neonatal prognoses did not differ between the delivery modes, treatment options, timing of cardiac surgery and sequence of cardiac myxoma resection in relation to delivery. CONCLUSION: The diagnosis of cardiac myxoma in pregnancy is important. Surgical treatment of cardiac myxoma in the pregnant patients has brought about favorable maternal and feto-neonatal outcomes in the delivery group, which might be attributable to the shorter operation duration and non-emergency nature of the surgical intervention. Proper timing of cardiac surgery and improved cardiopulmonary bypass conditions may result in even better maternal and feto-neonatal survivals.

Infected Cardiac Myxoma: an Updated Review.

OBJECTIVE: This study aims to present an updated clinical picture of the infected cardiac myxoma. Revankar & Clark made a systematic review of infected cardiac myxoma based on the literature before 1998. Since then, there has not been any updated information describing its recent changing trends. METHODS: A comprehensive literature search of infected cardiac myxoma was conducted on MEDLINE, Highwire Press and Google between 1998 and 2014. RESULTS: In comparison with Revankar & Clark's series, the present series disclosed a significantly decreased overall mortality. It is believed that refinement of the prompt diagnosis and timely management (use of sensitive antibiotics and surgical resection of the infected myxoma) have resulted in better outcomes of such patients. CONCLUSION: The present series of infected cardiac myxoma illustrated some aggravated clinical manifestations (relative more occasions of high-grade fever, multiple embolic events and the presence of refractory microorganisms), which should draw enough attention to careful diagnosis and treatment. In general, the prognosis of infected cardiac myxoma is relatively benign and the long-term survival is always promising.

[Aggressive angiomyxoma of the vulva. Case report and literature review]. / Angiomixoma agresivo de la vulva. Informe de un caso y revisión de la bibliografía.

Aggressive angiomyxoma is a rare vulvovaginal, perineal or pelvic mesenchymal neoplasm with a marked tendency to local recurrence but does not metastasize. A case of an aggressive angiomyxoma of vulva in a 39-years-old women with an illness of one year prior to examination, with a slow and progressive growth of the left vulvar region, without other symptoms. During physical examination, a piriform tumor of 15x10 cm was found, located on the left labia majora, soft tissue dependent. Wide resection of the tumor were performed. Hystopathology reported an aggressive angiomyxoma of the vulva, with tumor in resection margins. The patient was treated with a 65Gy postsurgical radiotherapy and gosereline 3.6 mg monthly, during 6 cycles. Aggressive angiomyxoma is a rare neoplasm 150 cases has been reported. The treatment is surgical resection. Radiotherapy and hormonal adyuvant is not fully stablished.

[Cardiac myxomas and the Carney complex]. / Mixomas cardiacos y complejo de Carney.

The study involved 63 patients with an echocardiographic, surgical and histopathologic diagnosis of cardiac myxoma who were seen over a period of 20 years. Tumor recurrence or relapse was documented in five of these patients (7.9%), 3 of whom had a confirmed diagnosis of Carney complex, while one other patient had a probable diagnosis. Genetic studies demonstrated abnormalities in the PRKAR1A gene on chromosome 17 in 2 patients and their immediate family. In 11 of the 58 patients who did not experience relapse of the myxoma, genetic studies failed to show any abnormality. In conclusion, the possible presence of the Carney complex should be investigated in patients with multiple myxomas or with a cardiac myxoma whose location is atypical.

Mixoma odontogênico: avaliação imaginológica de um caso tratado com crioterapia / Odontogenic myxoma: imaginologic evaluation of a case treated with cryotherapy

O mixoma odontogênico é um tumor benigno de crescimento lento, que promove aumento de volume ósseo e deslocamento dentário. O seu comportamento infiltrativo, responsável pela recorrência, justifica-se pela abundante matriz extracelular e ausência de cápsula. O tratamento ideal é a ressecção com margem de segurança, porém, a enucleação associada à crioterapia é uma alternativa menos agressiva...

Mixoma de átrio direito com prolapso para o ventrículo direito / Right atrial myxoma prolapsing into the right ventricle

Relatamos o caso raro de uma paciente de 67 anos, apresentando mixoma de átrio direito, com prolapso para o ventrículo direito. Estes tumores correspondem a cerca de 18 por cento dos casos de mixoma, que por sua vez têm uma incidência de 0,0017 por cento na população em geral.

We report on a rare case of a 67-year-old woman with a right atrial myxoma prolapsing into the right ventricle in the diastolic phase. These tumors comprise approximately 18 percent of all cardiac myxomas, which occur in 0.0017 percent of collected autopsy series.

Mixoma odontogênico: relato de caso clínico / Odontogenic myxoma: report of clinical case

O presente trabalho relata um caso clínico de mixoma odontogênico, apresentando sua etiologia e tratamento. descreve suas características clínicas, radiográfias e histopatológicas, importantes no diagnóstico diferencial

Mixoma de maxila / Myxoma of the maxilla

Os autores fazem o relato de caso clínico de mixoma que acomete maxila. A curetagam associada à crioterapia foi o tratamento realizado. Frente à bibliografia, verificaram que esta terapia oferece condições para enucleação da lesão evitando seqüelas ao paciente

Mixoma de maxila: relato de um caso clínico / Myxoma of upper jaw: report of case

É relatado um caso clínico-cirúrgico de mixoma de maxila, onde a lesão invadia toda a maxila direita e caminhava para a base do crânio. Para esse caso foi realizado o acesso extrabucal, facilitando a abordagem da neoplasia, que invadia parede lateral do seio, assoalho da órbita e caminhava no sentido do osso etmóide. O paciente está sendo proservado há dois anos e não apresenta sinais de neoplasia em atividade. Neste trabalho discutimos o tipo de terapêutica empregada