ABSTRACT
OBJECTIVE: To compare the molluscicidal effects and cost-effectiveness of 5% niclosamide ethanolamine salt granules (NEG) and 26% suspension concentrate of metalaldehyde and niclosamide ethanolamine salt (MNSC) . METHODS: Two plots with high Oncomelania hupensis snail density were selected as research areas in Nanjing Chemical Industry Zone, and 5% NEG (40 g/m2) and 26% MNSC (40 g/m2) were used by the spraying method for snail control in the two plots, and their molluscicidal effects and cost-effectiveness were investigated and statistically analyzed. RESULTS: There was no significant difference between 5% NEG and 26% MNSC in the molluscicidal effects. The cost of 5% NEG was 1.25 times higher than that of 26% MN-SC per ten thousand square meters in snail control. CONCLUSIONS: The cost of 5% NEG is higher than that of 26% MNSC per ten thousand square meters in snail control. Their molluscicidal effects are similar.
Subject(s)
Acetaldehyde/analogs & derivatives , Ethanolamines , Molluscacides , Snails , Acetaldehyde/economics , Acetaldehyde/pharmacology , Acetaldehyde/standards , Animals , Ethanolamine/economics , Ethanolamine/pharmacology , Ethanolamine/standards , Ethanolamines/economics , Ethanolamines/pharmacology , Ethanolamines/standards , Molluscacides/economics , Molluscacides/pharmacology , Molluscacides/standards , Niclosamide/economics , Niclosamide/pharmacology , Niclosamide/standards , Snails/drug effectsABSTRACT
The synthesis of new furo-salicylanilides and their heterocyclic derivatives is described. Twenty-three compounds were screened for their molluscicidal activity against Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni. Five of the tested compounds showed no activity, while eighteen compounds showed strong to moderate activity using bayluscide as a reference.
