Intermittent Exotropia: The Effect of Alternating Occlusion Therapy on Control of Strabismus.

BACKGROUND: Intermittent exotropia is a common form of pediatric strabismus characterized by intermittent misalignment of the eyes. This study investigated the clinical effectiveness of alternating occlusion therapy as a non-surgical alternative for children aged 3-10 with intermittent exotropia. METHODS: A comprehensive review of recent research, including randomized controlled trials and case series, was conducted. These studies utilized standardized control scores to assess the impact of alternating occlusion therapy on both distance and near control of alignment. RESULTS: The findings indicated a significant improvement in exotropia control, particularly at distance fixation, among children undergoing alternating occlusion therapy. While some variability in outcomes exists, all articles demonstrate positive responses to this noninvasive approach. Notably, the patients with poor initial control tended to benefit the most. DISCUSSION: The potential advantages of alternating occlusion therapy are its cost-effectiveness and noninvasive nature. However, it is essential to manage patient and parental expectations and address potential drawbacks, including social stress, irritation associated with occlusion therapy and the possibility that strabismus surgery may still be needed in the future because of decompensation. CONCLUSION: Alternating occlusion therapy is a promising option to improve exotropia control in children with intermittent exotropia. It offers a viable non-surgical strategy to delay or potentially avoid strabismus surgery, although approximately 45% of the patients might eventually still require strabismus surgery. Healthcare providers should carefully weigh the benefits and limitations of this intervention to make informed decisions through shared decision-making with the patients and their families. This review offers diverse insights into the clinical management of intermittent exotropia and provides an evidence-based alternative to surgical interventions.

Perinatal outcomes after selective feticide via umbilical cord occlusion in complicated monochorionic pregnancies: A systematic review and meta-analysis.

OBJECTIVE: We aimed to compare perinatal outcomes between umbilical cord occlusion techniques in monochorionic pregnancies, including umbilical cord ligation, fetoscopic laser coagulation, interstitial laser coagulation, bipolar cord occlusion, radiofrequency ablation, and microwave ablation. METHODS: This study was registered with PROSPERO (CRD42020158861). PubMed, Web of Science, Cochrane Library, and Embase were searched for studies published up to May 2020. The DerSimonian-Laird random-effects model was used for the meta-analysis. Subgroup analyses were performed to compare the outcomes among the six techniques. Meta-regression was used to adjust for confounders. RESULTS: Thirty-four studies with 1646 participants were included. The overall survival was 76.5% after umbilical cord ligation, 78.8% after fetoscopic laser coagulation, 60.3% after interstitial laser coagulation, 79.2% after bipolar cord occlusion, 77.5% after radiofrequency ablation, and 75.0% after microwave ablation. Subgroup comparison showed the rates of overall survival and preterm premature rupture of membranes were not significant different among six techniques. However, rates of fetal loss, premature birth, live birth, and neonatal death differed significantly among the six groups. CONCLUSIONS: The choice of umbilical cord occlusion techniques will affect perinatal outcomes. We suggested that the choice of umbilical cord occlusion techniques should fully consider these differences among techniques.

Glaucoma e óleo de silicone / Glaucoma and silicone oils

RESUMO O óleo de silicone é um importante tampão utilizado na retinopexia cirúrgica de casos graves de descolamento de retina. O aumento da pressão intraocular e o desenvolvimento de glaucoma secundário são frequentes complicações da sua utilização. A depender do período de aparecimento, diversos mecanismos justificam a ocorrência de tais complicações. Compreender os fatores de riscos e a patogênese do aumento da pressão intraocular associada a aplicação de óleo de silicone em cirurgia retiniana ajuda a orientar o tratamento adequado para cada paciente. O objetivo deste artigo é revisar a literatura sobre a patogenia, a incidência, os fatores de risco e o tratamento desta condição clínica.

ABSTRACT Silicone oil has been an important intraocular tamponade in retinopexy in cases of complicated retinal detachment surgery. The increase of intraocular pressure and development of secondary glaucoma are a known complication of its use. A variety of mechanisms have been proposed for the pathogenesis, depending on the onset. This article aims to review the literature about pathogenesis, the incidence and risk factors, as well as the treatment of this pathology.

Cuantificación digital de integración de injertos de piel de espesor parcial ocluidos con sistema de presión negativa / Digital quantification of integration in occluded partial-thickness skin grafts with negative pressure system

INTRODUCCIÓN Y OBJETIVO: El éxito en la integración de los injertos de piel de espesor parcial no depende de un solo factor, siendo uno de los más importantes el método de curación que se le realiza al injerto. Por tal razón, el objetivo de nuestro estudio es demostrar, a través de un programa digital informático, el porcentaje de integración que tienen los injertos de piel de espesor parcial a los que se realizó curación oclusiva con sistema de presión negativa. MATERIAL Y MÉTODO: Estudio descriptivo retrospectivo que toma como muestra todos los pacientes con defectos de cobertura y lecho receptor con tejido de granulación óptimo para realizar injerto de piel de espesor parcial, del Servicio de Cirugía Plástica de la Clínica Reina Catalina sede Barranquilla y Baranoa, en Colombia, desde el 1 de enero de 2019 hasta 31 de diciembre del mismo año. Empleamos el sistema de presión negativa WoundPro(R) (Ї#x00a9;2020 Pensar Medical, LLC) y posteriormente cuantificamos la integración de los injertos de forma digital a través de un programa de procesamiento de imágenes (ImageJ(R)), complementado con un desarrollo informático del Área de Sistemas de la Clínica para obtener un resultado matemático que permitiera, de manera más objetiva, evaluar la integración del injerto. RESULTADOS: Revisamos 70 pacientes, de los que 42 eran varones, con una edad promedio de 41.8 años. La etiología más común fue la quemadura (34%), el área anatómica de mayor incidencia fue la pierna (27.7%) y el porcentaje promedio de integración fue del 98.4%. Aplicamos el sistema de presión negativa durante 6 días para luego retirarlo y proceder a la toma de imagen fotográfica que usamos como insumo para el cálculo de la integración; tras la primera cura, el paciente es egresado y realizamos seguimiento ambulatorio, con una media de curación del área injertada de 17 días. CONCLUSIONES: En nuestra experiencia, el uso del sistema de presión negativa como método de curación oclusiva en los injertos de piel parcial, presenta tasas de éxito superiores al 98% en la integración de los injertos, lo cual se traduce en un tratamiento coste - efectivo ya que reduce las complicaciones inherentes al procedimiento. Así mismo, el cálculo matemático de la integración del injerto permite evaluar y definir de forma específica la conducta en cada caso

BACKGROUND AND OBJECTIVE: Success in the integration of partial thickness skin grafts does not depend on a single factor; one of the most important factors is the healing method performed on the skin graft. For this reason, the objective of our study is to demonstrate the percentage of integration through a digital computer program of the partial thickness skin grafts that underwent occlusive healing with the use of the negative pressure system. METHODS: Retrospective descriptive study. All patients with coverage defects, who had a wound with optimal granulation tissue to perform the partial thickness skin graft, were taken as a sample in the Plastic Surgery Service of the Reina Catalina Clinic in Barranquilla and Baranoa in Colombia, from January 1, 2019 to December 31 of the same year. For this, the WoundPro(R) negative pressure system (Ї#x00a9;2020 Pensar Medical, LLC) was used and the integration of the grafts was digitally quantified throug an image processing program (ImageJ(R)) complemented with a computerized developer of the Systems Area of the Clinic to obtain a mathematical result that would allow, more objectively, to evaluate the integration of the graft. RESULTS: Seventy patients were part of the study, the male gender was the most affected with 42 cases, the average age was 41.8 years. The most common etiology was burn (34%), the anatomical area with the highest incidence was the leg (27.7%) and the percentage integration average was 98.4%. The negative pressure system was applied for 6 days, then it was removed and the photographic record was made; that image was used to calculate the integration. After the first cure, the patient was discharged and follow-up was performed on an outpatient basis, with a healing average of the grafted area of 17 days. CONCLUSIONS: In our experience, the use of the negative pressure system as an occlusive healing method in partial skin grafts has represented success rates greater than 98% in the integration of the grafts, which translates into a cost-effective treatment since it reduces the complications inherent to this procedure. Likewise, the mathematical calculation of the graft integration makes possible the specific evaluation and definition of the behavior in each case

Transcatheter Closure of Patent Ductus Arteriosus under Echocardiography Guidance: A Randomized Controlled Noninferiority Trial.

BACKGROUND: Percutaneous occlusion under fluoroscopy guidance has become the preferred method for the treatment of patent ductus arteriosus (PDA). To avoid radiation exposure and contrast agent use, PDA occlusion under transthoracic echocardiography (TTE) guidance was conducted. OBJECTIVES: We assessed the hypothesis that the success rate of percutaneous PDA occlusion under TTE was noninferior to that under fluoroscopy guidance. METHODS: In this single-center trial, 100 patients were randomly assigned in a 1 : 1 ratio to the TTE group (n = 50) or to the fluoroscopy group (n = 50). The primary endpoint was the success rate of occlusion, with the noninferiority margin set at 8% for the between-group difference in intention-to-treat analysis. Secondary endpoints were hospitalization duration, cost, procedure time, and rate of adverse events including occluder migration, hemolysis, peripheral vascular complications, and residual shunt at 1-month and 12-month follow-up. RESULTS: Patient, defect, and device characteristics were similarly distributed between groups. The success rate of occlusion was 98% for the TTE group and 100% for the fluoroscopy group (absolute difference: -2%; 95% confidence interval: -5.9% to 1.9%). Cost and procedure duration were significantly lower in the TTE group, without adverse events in either group at a median of 12.0 months (range, 10.0-15.5 months) of follow-up. CONCLUSION: Percutaneous PDA occlusion can be performed via TTE guidance safely and effectively, and the success rate of the TTE-guided procedure was noninferior to that under fluoroscopy guidance, with reduced cost and procedure time. The trial is registered with http://www.chictr.org.cn (ChiCTR-ICR-15006334).

Aortopulmonary Collaterals in Single Ventricle Physiology: Variation in Understanding Occlusion Practice Among Interventional Cardiologists.

Although aortopulmonary collaterals (APCs) frequently develop in patients with single ventricle palliation, there is a lack of understanding of pathophysiology, natural history, and outcomes with no universal guidelines for management and interventional practice. We conducted a study to assess the views held by interventional congenital cardiologists regarding the hemodynamic impact of APCs in patients with single ventricle palliation, and their embolization practice. An electronic survey using the Pediatric Interventional Cardiology Symposium (PICS) mailing list was conducted between February and March 2019 with one reminder sent 2 weeks after initial invitation for participation. Of the 142 interventional cardiologist respondents, 95 (66.9%) reside in North America and 47 (33.1%) worldwide. We elected to exclude the data from interventionalists outside North America in this analysis as it was not representative of worldwide practice. Hypoxemia was considered to be the most common trigger for development of APCs by 56 (58.9%) respondents. After completion of total cavopulmonary connection, 30 (31.6%) respondents reported the APC burden stays the same while 31 (32.6%) feel it decreases. In evaluating the burden of APC flow, only 4 (4.2%) reported measuring oxygen saturation at different pulmonary artery segments, 21 (22.1%) perform segmental aortic angiograms, and 18 (19%) perform selective bilateral subclavian artery angiograms. A majority of respondents, 71 (74.7%), occlude the feeder vessel at different locations, while 10 (10.5%) occlude only the origin of the vessel. Our study demonstrates significant variation in the understanding of the cause and prognosis of APCs in patients with single ventricle palliation. Furthermore, there is variation in the approach for diagnosis and management among interventional cardiologists. Further studies are required to improve understanding of APCs and develop universal management guidelines.

Entrenamiento con restricción parcial de flujo sanguíneo en personas con enfermedades cardiovasculares: una revisión exploratoria / Blood flow restriction training for people with cardiovascular disease: an exploratory review

OBJETIVO: Analizar la evidencia sobre los efectos del entrenamiento con restricción parcial del flujo sanguíneo en personas con enfermedades cardiovasculares. MATERIALES Y MÉTODOS: Se realizó una búsqueda en las bases de datos de MEDLINE, EMBASE, SPORTDiscus, CINAHL, LILACS, SCOPUS y Wiley. Fueron incluidos estudios experimentales y no experimentales que investigaron sobre los efectos de la restricción parcial del flujo sanguíneo en sujetos con enfermedad cardiovascular. RESULTADOS: Seis ensayos clínicos y tres estudios no experimentales cumplieron los criterios de inclusión. Los estudios experimentales fueron realizados en sujetos con hipertensión arterial y enfermedad isquémica del corazón. Los estudios no experimentales describieron las adaptaciones hemodinámicas y los potenciales efectos secundarios de la terapia. El riesgo de sesgo de los ensayos clínicos incluidos fue de moderado a alto. El estrés hemodinámico inducido por el ejercicio aumenta significativamente durante el entrenamiento con restricción parcial del flujo sanguíneo en comparación al entrenamiento tradicional. La limitada cantidad de estudios disponibles se han centrado mayoritariamente en los efectos agudos, sin embargo, los efectos crónicos son desconocidos. CONCLUSIÓN: Actualmente no hay evidencia que recomiende el uso de la restricción parcial del flujo sanguíneo en personas con enfermedades cardiovasculares

OBJECTIVE: To analyse the evidence on the effects of blood flow restriction training in people with cardiovascular disease. MATERIALS AND METHODS: We searched MEDLINE, EMBASE, SPORTDiscus, CINAHL, LILACS, SCOPUS and Wiley databases. Experimental and non-experimental studies investigating the effects of blood flow restriction in participants with cardiovascular disease were included. RESULTS: Six clinical trials and three non-experimental studies met the inclusion criteria. The experimental studies were conducted in participants with hypertension and ischaemic heart disease. Non-experimental studies described hemodynamic adaptations and potential adverse effects of therapy. The risk of bias of the included clinical trials was moderate to high. Exercise-induced hemodynamic stress increased significantly during training with blood flow restriction compared with traditional training. The small number of available studies have focused mostly on acute effects, but chronic effects are unknown. CONCLUSION: There is currently no evidence to recommend the use of blood flow restriction in people with cardiovascular disease

A novel simple intra-corporeal Pringle maneuver for laparoscopic hemihepatectomy: how we do it.

INTRODUCTION: To prevent and control hemorrhage is the key to successfully perform laparoscopic hemihepatectomy (LHH). Pringle's maneuver (PM) is the standard hepatic inflow occlusion technique. Our study was to describe a novel simple way to perform totally intra-corporeal laparoscopic PM and to explore the feasibility of combining PM and selective hemihepatic vascular occlusion technique in LHH. METHODS: We extracted and analyzed the data of patients who consecutively underwent LHH to validate this new surgery technique. Between January, 2016 and December, 2017, 34 patients were included. Data of pre-operation, operation and post-operation were collected, including some demographic data, operative time, operative blood loss, transfusion rate, hepatic hilum occlusion rate and time, pathologic results, short-term complication, and postoperative hospitalization days. RESULTS: Only one patient (3.0%) in our series required conversion to laparotomy as a result of the severe adhesion. The average operative time was 216.9 ± 60.3 min. The mean hepatic inflow occlusion time was 25.3 ± 14.5 min. The average estimated blood loss was 192.9 ± 152.2 ml. All patients received R0 resection. CONCLUSION: The novel hepatic inflow occlusion device is a safe reliable and convenient technique for LHH that is associated with favorable perioperative outcomes and low risk of conversion.

Intermittent Splenic Artery Occlusion Plus Gauze Compression Is a Simple and Effective Treatment for Iatrogenic Splenic Injury.

BACKGROUND The aim of this study was to evaluate the feasibility and safety of intermittent splenic artery occlusion plus gauze compression in treating iatrogenic splenic injury. MATERIAL AND METHODS We retrospectively analyzed 12 iatrogenic splenic injury cases (grade I to III) treated with intermittent splenic artery occlusion plus gauze compression. The hemostatic effect was then observed after unblocking and decompression. The total operation time, gauze compression time, total blood loss, blood loss from the injured spleen, and platelet counts of each patient before and 1 week after surgery were noted. RESULTS The average operation time was 209.58±57.11 min, and the average gauze compression time after spleen artery occlusion was 23.75±4.33 min. The average total blood loss and blood loss due to iatrogenic spleen injury were 468.33±138.22 ml and 264.17±165.72 ml, respectively. Two cases (both grade I) had successful hemostasis after 15 min of splenic artery occlusion and wound compression. Another 9 cases (all grade II) and 1 case (grade III) attained hemostasis after 25 min and 30 min, respectively, of splenic artery occlusion and wound compression. The platelet counts of all patients were within the normal range before and 1 week after surgery. No postoperative complications occurred. CONCLUSIONS Intermittent splenic artery occlusion plus gauze compression is a simple and effective treatment for iatrogenic splenic injury.

Heterogeneous Response in Rabbit Fetal Diaphragmatic Hernia Lungs After Tracheal Occlusion.

BACKGROUND: Fetal tracheal occlusion (TO) is an experimental therapeutic approach to stimulate lung growth in the most severe congenital diaphragmatic hernia (CDH) cases. We have previously demonstrated a heterogeneous response of normal fetal rabbit lungs after TO with the appearance of at least two distinct zones. The aim of this study was to examine the fetal lung response after TO in a left CDH fetal rabbit model. METHODS: Fetal rabbits at 25 d gestation underwent surgical creation of CDH followed by TO at 27 d and harvest on day 30. Morphometric analysis, global metabolomics, and fluorescence lifetime imaging microscopy (FLIM) were performed to evaluate structural and metabolic changes in control, CDH, and CDH + TO lungs. RESULTS: Right and left lungs were different at the baseline and had a heterogeneous pulmonary growth response in CDH and after TO. The relative percent growth of the right lungs in CDH + TO was higher than the left lungs. Morphometric analyses revealed heterogeneous tissue-to-airspace ratios, in addition to size and number of airspaces within and between the lungs in the different groups. Global metabolomics demonstrated a slower rate of metabolism in the CDH group with the left lungs being less metabolically active. TO stimulated metabolic activity in both lungs to different degrees. FLIM analysis demonstrated local heterogeneity in glycolysis, oxidative phosphorylation (OXPHOS), and FLIM "lipid-surfactant" signal within and between the right and left lungs in all groups. CONCLUSIONS: We demonstrate that TO leads to a heterogeneous morphologic and metabolic response within and between the right and left lungs in a left CDH rabbit model.

Anatomic Considerations for Epicardial and Endocardial Left Atrial Appendage Closure.

Left atrial appendage closure is an increasingly used means of achieving thromboprophylaxis in atrial fibrillation, particularly in patients with contraindications to anticoagulation. Left atrial appendage anatomy is highly variable, and preprocedural imaging is critical to choosing the correct device and approach for left atrial appendage closure. This article reviews the common endocardial and epicardial closure systems, including anatomic considerations, advantages and disadvantages, as well as complications to be avoided.

Epicardial versus Endocardial Closure: Is One Better than the Other?

Left atrial appendage occlusion is an evolving technology with demonstrable benefits of stroke prophylaxis in patients with atrial fibrillation unsuitable for anticoagulation. This has resulted in the development of a plethora of transcatheter devices to achieve epicardial exclusion and endocardial occlusion. In this review, the authors summarize the differences in technique, target patient population, outcomes, and complication profiles of endocardial and epicardial techniques.

Effectiveness of the combat application tourniquet for arterial occlusion in young children.

BACKGROUND: Tourniquet use for extremity hemorrhage has become a mainstay in adult trauma care in last 15 years. The efforts of the Stop the Bleed campaign have increased the distribution and use of tourniquets in civilian settings in response to mass shootings and as part of disaster preparedness. Little research or published experience exists regarding the use of tourniquets in the pediatric population. This study sought to determine the minimum patient age on which the combat application tourniquet (CAT) is able to control extremity hemorrhage. METHODS: A convenience sample of pediatric patients, ages 1 year to 8 years, scheduled for elective orthopedic surgery at an academic hospital, were eligible for enrollment. Subject age, weight, height, blood pressure, and arm and leg circumferences were obtained. Once under general anesthesia, the pulse of an upper and a lower limb were obtained by Doppler, a CAT was then placed at the most proximal practical location of the limb until the corresponding pulse was either no longer obtainable by Doppler or until the tourniquet was as tight as its design allows. The tourniquet was removed after 30 seconds of arterial occlusion. RESULTS: Thirteen children, ages 2 years to 7 years were enrolled. Weights ranged from 12.8 kg to 23.9 kg, with a mean of 16.7 kg. Leg circumferences were 24.5 cm to 34.5 cm, with a mean of 27.9 cm and arm circumferences were 13 cm to 24 cm, with a mean of 16.3 cm. Subject heights were 87 cm to 122 cm, with a mean of 103.4 cm. Twenty-four total extremities were tested, 11 arms and 13 legs. Arterial occlusion was obtained on 100% of limbs tested (95% confidence interval, 85.8-100%). CONCLUSION: This study is similar to previous adult tourniquet efficacy studies in design, size and outcomes. It is the first to show successful arterial occlusion on preschool-aged children with a commercial tourniquet in a controlled setting. The results suggest that the CAT can be used in school-aged children with severe extremity hemorrhage with a high likelihood of success. LEVEL OF EVIDENCE: Therapeutic, level II.

The effect of alternate occlusion on control of intermittent exotropia in children.

PURPOSE: The aim is to investigate the effect of alternate occlusion on control of intermittent exotropia in children 3 to 8 years old. METHODS: The ability of 28 children to control of the deviation at far and near was evaluated based on 3-point and 6-point control scales. Stereopsis and fusion were assessed using the Titmus and Worth 4-dot tests, respectively. Two-hour alternate daily occlusion was prescribed for children with no dominancy. For children with a dominant eye, 2-h occlusion of the dominant eye for 5 days and the non-dominant eye for 2 days. All measurements were repeated at 3, 6, and 9 months after the treatment. RESULTS: For all children with a mean age of 4.7 ± 1.56 years, deviation control at far improved significantly after 3, 6, and 9 months of treatment using both control scales when compared with baseline (p = 0.005 after 3 months and p = 0.008 after 6 and 9 months for the 3-point scale, and p < 0.001 after 3 and 6 months and p = 0.010 after 9 months for the 6-point scale). Control at near showed a significant improvement after 3, 6, and 9 months of treatment based on the 6-point scale (p = 0.007 for 3 months, p = 0.004 for 6 months, and p = 0.014 for 9 months). Near stereopsis improved significantly after 9 months of treatment (p = 0.043). CONCLUSION: Alternate occlusion is significantly effective on control of intermittent exotropia. As a result, it can be used as a useful method to postpone or even eliminate the need for surgery in intermittent exotropia.

Clinical Profile and Treatment Outcomes of Amblyopia Across Age Groups.

PURPOSE: The purpose is to study the clinical profile of amblyopia by age at diagnosis. SUBJECTS AND METHODS: A retrospective chart review of 327 amblyopic patients over 7 years (September 2009-December 2016) was performed, divided by age at diagnosis into four groups: <3, 3-7, 8-15, and >15 years. Demographics, eye conditions and eye examination parameters including visual acuity (VA), refractive errors, and motility measurements were collected. RESULTS: Mean age at diagnosis and follow-up time was 6.2 ± 6.1 years standard deviation (SD) and 12.4 months ± 20.6 SD, respectively. The most common overall cause of amblyopia was strabismus (37%) followed by anisometropia (36%). The main causes by age at diagnosis were: strabismus at <3 years, anisometropia at 3-7 years, anisometropia at 8-15 years, and mixed at >15 years. Significant improvement in VA with treatment was noted with age between 3 and 15 years (3-7 years, P = 0.001 and 8-15 years, P = 0.03). CONCLUSIONS: Strabismus was the main cause of amblyopia at <3 years of age; anisometropia was more prevalent in older children (3-15 years). The fact that more than a quarter of our amblyopic patients were detected late (after the age of 8 years) underscores the need for expanded vision screening measures in young children.

Repetitive vascular occlusion stimulus (RVOS) versus standard care to prevent muscle wasting in critically ill patients (ROSProx):a study protocol for a pilot randomised controlled trial.

BACKGROUND: Forty per cent of critically ill patients are affected by intensive care unit-acquired weakness (ICU-AW), to which skeletal muscle wasting makes a substantial contribution. This can impair outcomes in hospital, and can cause long-term physical disability after hospital discharge. No effective mitigating strategies have yet been identified. Application of a repetitive vascular occlusion stimulus (RVOS) a limb pressure cuff inducing brief repeated cycles of ischaemia and reperfusion, can limit disuse muscle atrophy in both healthy controls and bed-bound patients recovering from knee surgery. We wish to determine whether RVOS might be effective in mitigating against muscle wasting in the ICU. Given that RVOS can also improve vascular function in healthy controls, we also wish to assess such effects in the critically ill. We here describe a pilot study to assess whether RVOS application is safe, tolerable, feasible and acceptable for ICU patients. METHODS: This is a randomised interventional feasibility trial. Thirty-two ventilated adult ICU patients with multiorgan failure will be recruited within 48 h of admission and randomised to either the intervention arm or the control arm. Intervention participants will receive RVOS twice daily (except only once on day 1) for up to 10 days or until ICU discharge. Serious adverse events and tolerability (pain score) will be recorded; feasibility of trial procedures will be assessed against pre-specified criteria and acceptability by semi-structured interview. Together with vascular function, muscle mass and quality will be assessed using ultrasound and measures of physical function at baseline, on days 6 and 11 of study enrolment, and at ICU and hospital discharge. Blood and urine biomarkers of muscle metabolism, vascular function, inflammation and DNA damage/repair mechanism will also be analysed. The Health questionnaire will be completed 3 months after hospital discharge. DISCUSSION: If this study demonstrates feasibility, the derived data will be used to inform the design (and sample size) of an appropriately-powered prospective trial to clarify whether RVOS can help preserve muscle mass/improve vascular function in critically ill patients. TRIAL REGISTRATION: ISRCTN Registry, ISRCTN44340629. Registered on 26 October 2017.

Follow-up after Percutaneous Patent Ductus Arteriosus Occlusion in Lower Weight Infants.

OBJECTIVES: To describe longer term outcomes for infants <6 kg undergoing percutaneous occlusion of the patent ductus arteriosus (PDA). STUDY DESIGN: This was a retrospective cohort study of infants <6 kg who underwent isolated percutaneous closure of the PDA at a single, tertiary center (2003-2017). Cardiopulmonary outcomes and device-related complications (eg, left pulmonary artery obstruction) were examined for differences across weight thresholds (very low weight, <3 kg; low weight, 3-<6 kg). We assessed composite measures of respiratory status during and beyond the initial hospitalization using linear mixed effects models. RESULTS: In this cohort of lower weight infants, 92 of 106 percutaneous occlusion procedures were successful. Median age and weight at procedure were 3.0 months (range, 0.5-11.1 months) and 3.7 kg (range, 1.4-5.9 kg), respectively. Among infants with pulmonary artery obstruction on initial postprocedural echocardiograms (n = 20 [22%]), obstruction persisted through hospital discharge in 3 infants. No measured variables were associated with device-related complications. Rates of oxygenation failure (28% vs 8%; P < .01) and decreased left ventricular systolic function (29% vs 5%; P < .01) were higher among very low weight than low weight infants. Pulmonary scores decreased (indicating improved respiratory status) following percutaneous PDA closure. CONCLUSIONS: Percutaneous PDA occlusion among lower weight infants is associated with potential longer term improvements in respiratory health. Risks of device-related complications and adverse cardiopulmonary outcomes, particularly among very low weight infants, underscore the need for continued device modification. Before widespread use, clinical trials comparing percutaneous occlusion vs alternative treatments are needed.