RUNX2 Nonsense Mutation Associated with Cleidocranial Dysplasia with Unusual Dental Features.

Purpose: The purpose of this case report is to describe a RUNX2 nonsense mutation associated with cleidocranial dysplasia (CCD) with unusual dental features. The patient was a 12-year-old Brazilian girl who sought dental care due to over-retention of primary teeth and absence of erupted permanent teeth. Clinical and radiographic examinations revealed multiple impacted permanent teeth, a prominent cingulum of the permanent impacted maxillary incisors and enamel defects (hypoplasia and hypomineralization) in addition to skeletal abnormalities. No supernumerary teeth were present. The diagnostic hypothesis of CCD was raised and the patient was refer- red to the genetic medical service, where the diagnosis was cofirmed. After RUNX2 genetic screening, including polymerase chain reaction and sequencing of both DNA strands, a heterozygous nonsense mutation was identified in exon 2 (c.193 C>T [Q65X]). This article reports unusual dental features in a patient with CCD.

Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis.

OBJECTIVE: To evaluate the association between orofacial clefts (OFC) and tooth abnormalities (TA). METHODS: We searched PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and BBO, and in the gray literature and selected observational studies that evaluated the association between TA and OFC. The risk of bias was analyzed using the Newcastle-Ottawa Scale. A random-effects meta-analysis was performed comparing the presence and absence of OFC, cleft type-cleft palate (CP) and cleft lip with or without palate (CL/P)-and cleft laterality-unilateral and bilateral. The certainty of evidence was evaluated using the GRADE approach. RESULTS: A total of 99 studies were included in the qualitative analysis, and 37 were included in the meta-analysis. Only four studies were classified as low risk of bias. Significant associations were observed between the presence of OFC and tooth agenesis (OR = 19.46; 95%CI = 4.99-75.96), supernumerary teeth (OR = 4.04; 95%CI = 1.26-12.99), developmental defects of enamel (OR = 3.15; 95%CI = 1.28-7.80), microdontia (OR = 15.57; 95%CI = 1.06-228.51), and taurodontism (OR = 1.74; 95%CI = 1.74-2.86). Individuals with CP had a lower frequency of supernumerary teeth (OR = 0.22; 95%CI = 0.08-0.64), peg-shaped tooth (OR = 0.31; 95%CI = 0.12-0.80), and morphological TA (OR = 0.13; 95%CI = 0.04-0.45) than individuals with CL/P. No TA was significantly associated with cleft laterality (p > 0.05). The quality of the evidence was very low in all analyses. CONCLUSION: Individuals with OFC had a higher frequency of TA than those without OFC. Individuals with CP had a lower frequency of TA than individuals with CL/P. No TA was associated to cleft laterality. CLINICAL RELEVANCE: Help to identify the treatment needs of individuals affected by OFC, improving the services provided to this population.

Pindborg tumor associated with a supernumerary tooth: a case report

The calcifying epithelial odontogenic tumor is a rare benign neoplasm that accounts for approximately 1% of all odontogenic tumors. Most of the cases occur in the posterior mandible, and a few involve the maxilla. Despite their relatively indolent biological behavior, tumors in the maxilla tend to grow fast. We report the case of a 33-year-old female patient exhibiting swelling in the right maxilla. An isodense area associated with an impacted supernumerary tooth was found on imaging examination. The histopathologic diagnosis was a calcifying epithelial odontogenic tumor. The treatment of choice was surgical removal of the lesion and associated dental elements. The patient has been followed up for 11 months and shows no signs of recurrence. Besides describing this case, we reviewed the literature on the association of calcifying epithelial odontogenic tumors with supernumerary teeth and found two case reports addressing this subject.

Supernumerary teeth in patients with cleft lip and palate: the tooth germs do not separate.

INTRODUCTION: Supernumerary teeth in cases of cleft lip and palate do not result from the division of normal germs before the formation of hard tissue. Deciduous and permanent teeth odontogenesis begins after the face has formed, either with or without the cleft. DISCUSSION: The most acceptable hypothesis to enable understanding of the presence of supernumerary teeth on one or both sides of the cleft palate is hyperactivity of the dental lamina in its walls. This hyperactivity, with the formation of more tooth germs, must be attributed to mediators and genes related to tooth formation, under strong influence of local epigenetic factors, whose developmental environment was affected by the presence of the cleft. CONCLUSION: The current concepts of embryology no longer support the fusion of embryonic processes for the formation of the face, but rather the leveling of the grooves between them. All human teeth have a dual embryonic origin, as they are composed of ectoderm and mesenchyme/ectomesenchyme, but this does not make it easy for them to be duplicated to form supernumerary teeth.

Supernumerary teeth in patients with cleft lip and palate: the tooth germs do not separate

ABSTRACT Introduction: Supernumerary teeth in cases of cleft lip and palate do not result from the division of normal germs before the formation of hard tissue. Deciduous and permanent teeth odontogenesis begins after the face has formed, either with or without the cleft. Discussion: The most acceptable hypothesis to enable understanding of the presence of supernumerary teeth on one or both sides of the cleft palate is hyperactivity of the dental lamina in its walls. This hyperactivity, with the formation of more tooth germs, must be attributed to mediators and genes related to tooth formation, under strong influence of local epigenetic factors, whose developmental environment was affected by the presence of the cleft. Conclusion: The current concepts of embryology no longer support the fusion of embryonic processes for the formation of the face, but rather the leveling of the grooves between them. All human teeth have a dual embryonic origin, as they are composed of ectoderm and mesenchyme/ectomesenchyme, but this does not make it easy for them to be duplicated to form supernumerary teeth.

RESUMO Introdução: Os dentes extranumerários nas fissuras labiopalatinas não são resultado da divisão dos germes normais antes da formação do tecido duro. A odontogênese dos decíduos e permanentes inicia-se depois de formada a face, com ou sem fissuras. Discussão: A hipótese mais plausível para compreender a presença dos dentes extranumerários em um ou nos dois lados da fissura labiopalatina é a hiperatividade da lâmina dentária em suas paredes. Essa hiperatividade, com formação de mais germes dentários, deve ser atribuída aos mediadores e genes relacionados à formação dos dentes, sob forte influência de fatores epigenéticos locais, cujo ambiente de desenvolvimento foi afetado pela presença da fissura. Conclusão: Os conceitos atuais da embriologia não fundamentam mais a fusão de processos embrionários para a formação da face, e sim o nivelamento dos sulcos entre eles. Todos os dentes humanos têm uma dupla origem embrionária, pois se compõem de ectoderma e mesênquima/ectomesênquima, mas isso não facilita sua duplicação para formar dentes extranumerários.

Supernumerario distomolar en rama mandibular asociado a quiste dentígero. Presentación de un caso / Distomolar Supernumerary in the mandibular ramus associated with a dentigerous cyst. A case presentation

Introducción: Los dientes supernumerarios son anomalías donde hay un aumento de la fórmula dental normal. Ocasionalmente provocan complicaciones, como la formación de un quiste dentígero. Por lo infrecuente del hallazgo, y más aún del reporte de esta asociación, se realizó la presentación del caso. Objetivo: Describir el manejo de un supernumerario distomolar en rama mandibular asociado a un quiste dentígero, enfatizando en la importancia de los estudios imaginológicos preoperatorios y el abordaje quirúrgico endobucal. Presentación del caso: Paciente femenina de 34 años, que se extrajo los terceros molares en la adolescencia, y que 3 meses atrás presentó una celulitis facial por la que se le realizó una ortopantomografía, y se detectó un molar en la rama mandibular. Al examen bucal se encontró ligera expansión de la tabla vestibular de rama mandibular izquierda. Se constató en la ortopantomografía la presencia de una estructura dentaria del grupo molar asociada a área radiolúcida, lo que se corroboró en una tomografía. Se planificó la exéresis de ambos mediante abordaje endobucal bajo anestesia general. No se presentaron complicaciones. La paciente fue egresada a las 24 horas y fue seguida evolutivamente por consulta externa durante 6 meses. El diagnóstico histopatológico indicó la presencia de un quiste. Conclusiones: La detección de un diente supernumerio distomolar en rama mandibular asociado a quiste dentígero es una situación clínica infrecuente que permite explotar los beneficios de estudios imaginológicos digitales y crear un plan de tratamiento que culmine en la exéresis exitosa por vía endobucal, sin complicaciones(AU)

Introduction: Supernumerary teeth are anomalies in which there is an increase of the normal dental formula. They occasionally cause complications, such as the formation of a dentigerous cyst. Because of the unusual finding, and even more because of the report of this association, a case presentation is carried out. Objective: To describe the management of a supernumerary distomolar in the mandibular ramus associated with a dentigerous cyst, making emphasis on the importance of the preoperative imaging studies and the endo-buccal surgery approach. Case presentation: 34 years old female patient from whom the third molars were removed during adolescence, who presented facial cellulitis 3 months before the molars removal, which was a reason to perform an orthopantomography. Then, a molar in the mandibular ramus was detected. During oral examination, a light vestibular table expansion in the left mandibular ramus was found. The presence of a dental structure from the molar group which was associated with a radiolucent area was confirmed by orthopantomography, and was also confirmed by CT-scan. Exeresis of both molars under general anesthesia was planned, with an endo-buccal approach. There were no complications. The patient was discharged 24 hours later, and was treated in the outpatient consulting room for 6 months. Histopathological diagnosis revealed the presence of a cyst(AU) Conclusions: The finding of a supernumerary distomolar tooth in the mandibular ramus associated with a dentigerous cyst is an infrequent clinical situation that allows to make good use of the benefits of digital imaging studies, and implement a treatment plan that ends in a successful exeresis via an endo-buccal route, without any complications(AU)

An Uncommon Occurrence of Three-Fourth Molars Concomitant to Hypodontia in a Nonsyndromic Patient.

Bilaterally mandibular and maxillary fourth molars, concomitant to hypodontia, are uncommon. These dental anomalies, called hypohyperdontia, are rare and etiology is not well defined. Several complications may occur as a consequence of supernumerary teeth, such as teeth impaction, resorption of adjacent teeth, and development of cysts and tumors. The authors present an uncommon occurrence of three-fourth molars concomitant to hypodontia and dentigerous cyst associated with impacted mandibular second and third molars in a nonsyndromic patient. The authors attempt to discuss the occurrence of bilaterally fourth molars and reinforce the importance of clinical approach, considering risks and benefits for the patient.

Retenção prolongada de dente decíduo por impactação de dente supranumerário em criança de 12 anos / Tooth prolonged retention of deciduous tooth impaction supernumerary in children under 12 years

Dente supranumerário é definido como um distúrbio de desenvolvimento caracterizado pela presença de um ou mais elementos dentários fora do número considerado normal de uma arcada. A ocorrência dos supranumerários pode ocasionar uma variedade de complicações, como por exemplo, apinhamento de dentes permanentes, erupção retardada e/ou ectópica, rotação dentária, formação de diastema, desenvolvimento de lesões císticas, reabsorção de dentes adjacentes. Na maioria das vezes o diagnóstico da presença desse elemento é realizado por exame clínico e radiográfico de rotina. O objetivo do presente trabalho foi relatar um caso clínico de retenção prolongada de um dente decíduo e erupção retardada de um dente permanente em decorrência da presença de um elemento supranumerário diagnosticado apenas aos 12 anos de idade. Após a identificação do elemento supranumerário e análise de exames radiográficos complementares,foi realizada cirurgia para remoção dos elementos decíduo e supranumerário, bem como acompanhamento por três meses do processo eruptivo do elemento impactado,um segundo pré-molar inferior direito o qual se posicionou favoravelmente na arcada dentária. Concluiu-se que a detecção em momento oportuno e a remoção de elementos supranumerários, também respeitadas à necessidade e oportunidade cirúrgica, são importantes para evitar danos futuros à oclusão dos pacientes, devendo-se dar importância ao acompanhamento e evolução clínica do caso.

Supernumerary teeth is defined as a developmental disorder characterized by the presence of one or more dental elements out of a number considered normal arch. The occurrence of supernumerary can cause a variety of complications, such as crowding of the permanent teeth,delayed and / or ectopically erupting, tooth rotation, diastema training, development of cysticlesions, resorption of adjacent teeth. In most cases the diagnosis of the presence of this elementis made by clinical examination and routine radiographic. The aim of this study was to reporta case of prolonged retention of a primary tooth eruption and delayed a permanent tooth dueto the presence of a supernumerary element diagnosed only 12 years old. After identifying the supernumerary element and analysis of complementary radiographs, it was carried out surgeryto remove the elements deciduous and supernumerary and monitoring for 3 months of the eruptive process impacted element, a premolar law that favorably-positioned in the dental arch.It was concluded that the timely detection and removal of supernumerary elements also respected the need and surgical opportunity, are important to prevent future damage to the occlusion of patients, should be given importance to the monitoring and clinical outcome.

Combined Surgical Removal of a Supernumerary Tooth and Orthodontic Traction of an Impacted Maxillary Central Incisor.

Impaction of permanent maxillary central incisors is a rare condition that can affect esthetics and oral function. The etiology of impaction is multifactorial and may be related to embryologic reasons, hereditary factors, mechanical obstacles, and pathologic elements, such as the presence of supernumerary teeth. The purpose of this report is to discuss the case of a 10-year-old patient who presented an impacted permanent maxillary right central incisor due to a supernumerary tooth. Surgical removal of the supernumerary tooth and orthodontic traction of the impacted central incisor by the closed eruption technique were performed. After 12 months, the permanent maxillary right central incisor was adequately positioned in the arch. The multidisciplinary treatment allowed the functional and esthetic rehabilitation to happen in a short period of time, thus reducing the patient's psychological impact caused by the lack of an anterior tooth.

Bilateral mandibular fourth molars: A case report.

INTRODUCTION: Fourth molars are supernumerary teeth located distal to the third molars that may cause local alterations. Therefore an adequate diagnosis and treatment are essential. Removal of the supernumerary tooth and, in selected cases, maintenance of the tooth on the arch and frequent observation are the preferred treatments. If the extraction is recommended, it should be performed carefully by experienced oral surgeons to prevent damage to the anatomical structures. OBSERVATION: The oral examination of a 26-year-old woman revealed a left partially impacted mandibular molar responsible for pain and infection. Although it was assumed it was a third molar, the panoramic radiograph showed that the real third molar was completely impacted and that two partially impacted mandibular fourth molars were present bilaterally. Both of them were removed without complications and the left third molar was extracted after fragmentation to avoid any injury of the contiguous inferior alveolar nerve. DISCUSSION: The extraction of the left fourth molars solved the pain. Even if the right fourth molar was asymptomatic, the patient accepted its extraction because of the evident radiographical pericoronitis and to avoid further complications. "Asymptomatic" does not mean absence of disease, but the patient's consent is mandatory before any decision.

Surgical-orthodontic treatment of Class III malocclusion with agenesis of lateral incisor and unerupted canine.

INTRODUCTION: Orthodontic-surgical treatment was performed in patient with skeletal Class III malocclusion due to exceeding mandibular growth. Patient also presented upper and lower dental protrusion, overjet of -3.0 mm, overbite of -1.0 mm, congenital absence of tooth #22, teeth #13 and supernumerary impaction, tooth #12 with conoid shape and partly erupted in supraversion, prolonged retention of tooth #53, tendency to vertical growth of the face and facial asymmetry. The discrepancy on the upper arch was -2.0 mm and -5.0 mm on the lower arch. METHODS: The presurgical orthodontic treatment was performed with extraction of the teeth #35 and #45. On the upper arch, teeth #53, #12 and supernumerary were extracted to accomplish the traction of the impacted canine. The spaces of the lower extractions were closed with mesialization of posterior segment. After aligning and leveling the teeth, extractions spaces closure and correct positioning of teeth on the bone bases, the correct intercuspation of the dental arch, with molars and canines in Angle's Class I, coincident midline, normal overjet and overbite and ideal torques, were evaluated through study models. The patient was submitted to orthognathic surgery and then the postsurgical orthodontic treatment was finished. RESULTS: The Class III malocclusion was treated establishing occlusal and facial normal standards.

Surgical-orthodontic treatment of Class III malocclusion with agenesis of lateral incisor and unerupted canine

INTRODUCTION: Orthodontic-surgical treatment was performed in patient with skeletal Class III malocclusion due to exceeding mandibular growth. Patient also presented upper and lower dental protrusion, overjet of -3.0 mm, overbite of -1.0 mm, congenital absence of tooth #22, teeth #13 and supernumerary impaction, tooth #12 with conoid shape and partly erupted in supraversion, prolonged retention of tooth #53, tendency to vertical growth of the face and facial asymmetry. The discrepancy on the upper arch was -2.0 mm and -5.0 mm on the lower arch. METHODS: The pre-surgical orthodontic treatment was performed with extractions of the teeth #35 and #45. On the upper arch, teeth #53, #12 and supernumerary were extracted to accomplish the traction of the impacted canine. The spaces of the lower extractions were closed with mesialization of posterior segment. After aligning and leveling the teeth, extractions spaces closure and correct positioning of teeth on the bone bases, the correct intercuspation of the dental arch, with molars and canines in Angle's Class I, coincident midline, normal overjet and overbite and ideal torques, were evaluated through study models. The patient was submitted to orthognathic surgery and then the post-surgical orthodontic treatment was finished. RESULTS: The Class III malocclusion was treated establishing occlusal and facial normal standards.

INTRODUÇÃO: o presente trabalho apresenta um tratamento ortodôntico-cirúrgico realizado em paciente portadora de má oclusão de Classe III esquelética com crescimento mandibular, protrusão dentária superior e inferior, trespasse horizontal de -3,0mm, trespasse vertical de -1,0mm, ausência congênita do dente 22, dentes 13 e supranumerários inclusos, dente 12 com forma conoide e parcialmente irrompido em supraversão, retenção prolongada do dente 53, tendência ao crescimento vertical da face e assimetria facial. A discrepância na arcada superior era de -2,0mm, e na inferior era de -5,0mm. MÉTODOS: o tratamento ortodôntico pré-cirúrgico foi realizado com extrações dos dentes 35 e 45. Na arcada superior foram extraídos os dentes 53, 12 e supranumerário, para efetuar o tracionamento do canino incluso. Os espaços das extrações inferiores foram fechados com mesialização do segmento posterior. Após o alinhamento e nivelamento dos dentes, foram avaliados por meio de modelos de estudo o fechamento dos espaços das extrações e o posicionamento correto dos dentes nas bases ósseas, a intercuspidação correta das arcadas dentárias, com molares e caninos em Classe I de Angle, linhas medianas coincidentes, trespasse horizontal e trespasse vertical normais e torques ideais. A paciente foi encaminhada para realização de cirurgia ortognática e, em seguida, o tratamento ortodôntico pós-cirúrgico foi finalizado. RESULTADOS: a má oclusão de Classe III foi corrigida, estabelecendo padrões oclusais e faciais normais.

Impacted incisors associated with supernumerary teeth treated with a modified Haas appliance.

Tooth impaction involves factors such as lack of space in the alveolar process, trauma, ankylosis, and mechanical barriers such as abnormal frenum, supernumerary teeth, tumors, and local cysts. When impaction occurs in the anterior region, esthetics are compromised. This report describes the successful approach to treatment for a young boy who had 2 supernumerary teeth associated with impaction of the left central and lateral permanent incisors. Treatment consisted of extracting the supernumerary teeth and performing maxillary expansion with a modified Haas appliance to guide the left central incisor into its appropriate position. The teeth erupted spontaneously after maxillary expansion and an increase in space. A fixed edgewise appliance was placed incrementally to correct the maxillary anterior tooth positions and finish the treatment. Adequate esthetics and function were achieved.

Manejo clínico de dientes supernumerarios en pacientes pediátricos / Manejo Clínico de dentes supranumerários em pacientes infantís / Clinical treatment for supernumerary teeth in pediatric patients

Los dientes supernumerarios (DS) son aquellos que se forman adicionalmente a la serie normal. Pueden ubicarse en cualquier área de los maxilares, siendo su forma cónica, tuberculada o suplementaria. Las alteraciones de oclusión frecuentemente asociadas son desplazamiento, retardo de erupción o impactación de los dientes vecinos. Objetivo: Describir la prevalencia de dientes supernumerarios, así como las consecuencias y terapéutica implementada para un grupo de pacientes pediátricos. Material y métodos: fueron evaluados los registros diagnósticos de 823 pacientes del Servicio de Ortodoncia Interceptiva, postgrado de Odontología Infantil U.C.V., determinando: forma, ubicación, consecuencias y tratamiento efectuado; los pacientes con síndromes o HLP fueron excluidos. Resultados: La prevalencia de dientes supernumerarios fue 5,47% con mayor proporción en el género masculino (1,8:1). La edad de diagnóstico fue 8,18 (±1,61). La forma cónica fue la más frecuente (45%), siendo el área apical anterior la más afectada (90%). El supernumerario produjo alteraciones en la posición de dientes adyacentes en 53,3%. El tratamiento incluyó odontectomía (63,3%) y conformación del arco dental (87,5%). Sólo 4 casos requirieron tracción ortodóncica. Conclusión: la prevalencia de dientes supernumerarios en esta muestra fue mayor a la reportada por otros autores, con predilección por el género masculino. El tratamiento se realizó de forma sincronizada por parte del equipo interdisciplinario que incluyó Odontopediatra y Cirujano Bucal, determinando que la remoción oportuna del DS permite la erupción de los dientes adyacentes, siempre que el espacio disponible sea favorable.

Os dentes supranumerários (DS), são aqueles que se formam adicionalmente à série dentária normal. Podem localizar-se em qualquer área dos maxilares, sendo a sua forma cônica, tuberculada ou suplementária. As alterações de oclusão frequentemnte associadas,são: deslocamento da posição original, retardo da erupção ou impactação dos dentes vizinhos. Objetivo: descrever a prevalência de dentes supranumerários, assim como as conseqüencias e terapêutica implementada para um grupo de pacientes infantís. Material e Metodo: foram avaliados os registros diagnósticos de 823 pacientes do Serviço de Ortodontia Interceptiva de Pósgraduação m Odontologia Infantíl U.C.V., determinando: forma, localização conseqüencias e tratamentos efetuados; os pacientes com síndromes ou HLP, foram excluídos. Resultados: A prevalência de dentes supranumerários foi de 5,47% com maior proporção no gênero masculino, (1,8:1). A idade de diagnóstico foi de 8,18 (:+1,61). A forma cônica foi a mais freqüente (45%), sendo a área apical anterior a mais afetada (90%). O supranumerário produziu alterações na posição dos dentes adjacentes em 53%. O tratamento incluiu odontotomia (63,3%) e coformação do arco dental (87,5%). So 4 casos requeriram tração ortodontica. Conclusão: A prevalência de dentes supranumerários em nossa mostra foi maior que a reportada por outros autores, com prevlência maior para o gênero masculino. O tratamento se realizou de forma sincronizada pela equipe interdisciplinar que incluiu Odontopediatra e Cirurgião Bucal, cdeterminano que a remoção oportuna do DS permite a erupção dos dentes adjacentes, sempre que o espaço disponível seja favorável.

Supernumerary teeth (ST) are those formed additionally to the normal dental series. They may be found in any area of the maxilla or mandible with conical, tuberculate o supplementary shape. They may produce occlusal anomalies, and are associated with displacement, eruption disturbances or impaction of adjacent teeth. Objetive: The aim of this study is to describe frequency, associated anomalies and treatment outcome for ST in a group of pediatric patients, from Caracas, Venezuela. Material and methods: 823 orthodontic records (radiographs, photographs) of pediatric orthodontic patients were analyzed. ST shape and location were registered, as well as consequences on adjacent teeth and treatment outcome. Patients with syndromes, systemic disorders or clefts were excluded. Results: Frequency of ST was 5,47%, with male: female ratio of 1.8:1. Mean age at diagnosis was 8.18 (± 1.61). Conical shape was most frequent (45%) and anterior apical area was the most affected (90%). The 73,33% of all patients presented one ST, 22,22% presented two and 4,44% three ST. Displacement of adjacent teeth was observed in 53.3%. Treatment performed included extraction of ST (63.3%) and space for adjacent teeth was gained by expansion and dental arch conformation (87.5%). Spontaneous eruption of adjacent teeth occurred in all but 4 cases, which required orthodontic extrusion. Conclusion: Frequency of ST in this sample was higher than reported in other studies. Treatment outcome was favorable in most cases when extraction of ST and dental arch conformation were performed in the mixed dentition, by multidisciplinary team that included pediatric dentistry and oral surgeon.

Treatment of supernumerary teeth.

AIM: The finding of supernumerary teeth in the oral cavity is a common occurrence, and they are interesting because of their potential to lead to aesthetic and functional alterations. When they are present in the anterior area of the maxilla, they may cause complications, such as late tooth eruption or impaction of the central incisors. They affect from 0.5 to 3.8% of the population, with men being more affected. CASE REPORTS: This article describes two cases of impaction of the permanent maxillary left central incisor, due to the presence of a supernumerary tooth in the parasagittal area of the pre-maxilla, as well as the surgical and orthodontic procedures adopted.

Endodontic treatment of dental formation anomalies / Tratamento endodôntico de anomalia dental de formação

PURPOSE: Dental fusion is defined as the union of two dental germs at some stage of their development. The aim of this article is to report the endodontic treatment of two clinical cases of dental fusion. CASE DESCRIPTION: In the first case, the patient was referred by an orthodontist for endodontic treatment of tooth 12, which was fused to 13. Surgical separation and later replacement of the involved elements in the dental arch was indicated. In the second case, the patient sought dental attendance due to spontaneous pain. In the radiographic exam, gemination in tooth 11 and fusion of 21 with a supernumerary tooth was observed. The fused teeth were endodontically treated, and patients were referred to other dental specialties to reestablish esthetics and function. CONCLUSION: The dentist must be able to diagnose, differentiate and treat these dental anomalies adequately, with the goal of maintaining patients' oral health.

OBJETO: Fusão dental é definida como sendo a união de dois germes dentais em algum momento do estágio de desenvolvimento. O objetivo desse artigo foi descrever o tratamento endodôntico de dois casos de fusão dental. DESCRIÇÃO DO CASO: No primeiro caso clínico, o paciente foi orientado pelo ortodontista a realizar tratamento endodôntico do dente 12, o qual estava fusionado ao dente 13. Foi realizada a separação cirúrgica dos elementos dentais e posterior reposicionamento no arco dental. No segundo caso clínico, o paciente procurou atendimento relatando dor espontânea na região anterior superior. Por meio do exame radiográfico, foi observado geminação do dente 11 e fusão do dente 21 com dente extranumerário. Em ambos os casos os dentes fusionados foram tratados endodônticamente e os pacientes encaminhados para restabelecimento da estética e função. CONCLUSÃO: O cirurgião dentista deve ter habilidade de diagnosticar, diferenciar e tratar adequadamente as anomalias dentárias, objetivando a manutenção da saúde oral dos pacientes.

Non-syndromic hypohyperdontia of the permanent dentition with involvement of the mandibular anterior region: a rare occurrence / Hipo-hiperdontia não sindrômica da dentição permanente com envolvimento da região anterior mandibular: uma rara ocorrência

Objective: To present an uncommon case of numeric abnormalities in a non-syndromic patient.Discussion: Dental numeric abnormalities in development of the permanent dentition are quite common;however, combined occurrence of hypodontia and hyperdontia is a rare phenomenon, especiallyin a non-syndromic situation. This paper describes a 28-year-old non-syndromic man with missing mandibularlateral incisors and an erupted mandibular mesiodens. This is only the third case, to the best ofour knowledge, with the two anomalies manifesting in the anterior region of the mandible.

Objetivo: Apresentar um caso incomum de anomalias numéricas num caso de paciente não sindrômico. Discussão:Anomalias dentárias numéricas no desenvolvimento da dentição permanente são comuns; entretanto, a ocorrênciacombinada de hipo e hiperdontia é um fenômeno raro, especialmente em situações não sindrômicas. Este artigo descreve o caso de um paciente masculino não sindrômico apresentando ausência de incisivos laterais mandibularese um mesiodens mandibular erupcionado. Esse é o único caso, pelo melhor de nosso conhecimento, com as duasanomalias manifestando-se simultaneamente na região anterior da mandíbula.

Multi-lobed mesiodens with a palatal talon cusp: a rare case report.

Mesiodens is a midline supernumerary tooth commonly seen in the maxillary arch and the talon cusp is a rare dental developmental anomaly seen on the lingual surface of anterior teeth. This paper presents a rare clinical case of development of talon cusp in a mesiodens with multiple lobes, which interfered with both occlusion and appearance of an 11-year-old patient. During clinical interview, the patient reported difficulty on mastication. Clinical and radiographic examination revealed that a supernumerary tooth with completely formed root was causing an occlusal interference. The supernumerary tooth was diagnosed as multi-lobed mesiodens associated with a palatal talon cusp. The treatment plan consisted in the extraction of the supernumerary tooth followed by orthodontic treatment for diastema closure and tooth alignment.

Class I malocclusion treatment: influence of a missing mandibular incisor on anterior guidance.

This case report describes the orthodontic treatment of a patient with a deep-overbite Angle Class I malocclusion, agenesis of a mandibular central incisor, and 2 supernumerary teeth, which caused impaction of the mandibular first premolars. The 15-year-old patient also had a convex profile, maxillary dentoalveolar protrusion, and deficiency of space for the correct alignment of teeth. Therefore, treatment consisted of fixed appliance therapy, cervical headgear, extraction of the supernumeraries and the mandibular and maxillary first premolars, and mesiodistal reduction of the maxillary incisors to solve the arch perimeter discrepancy as much as possible with interproximal stripping. This method of treatment significantly improved the patient's facial and dental esthetics and provided a good functional occlusion, despite the absence of a mandibular incisor, which generally impairs achieving adequate incisal guidance.

Autosomal-dominant ankyloglossia and tooth number anomalies.

Ankyloglossia is a congenital oral anomaly characterized by the presence of a hypertrophic lingual frenulum. It frequently accompanies X-linked cleft palate and is sometimes seen alone due to mutations in the gene encoding the transcription factor TBX22, while knockout of Lgr5 in the mouse results in ankyloglossia. The aim of the present study was to characterize the phenotype and to verify sequence variations in the LGR5 gene in a Brazilian family with ankyloglossia associated with tooth number anomalies. Twelve individuals of three generations were submitted to physical, oral, and radiographic examinations and molecular analysis. Eight had ankyloglossia with various degrees of severity. Six also had hypodontia in the lower incisor region; one had a supernumerary tooth in this region, and another had a supernumerary tooth in the lower premolar region. The characterization of this family determined an autosomal-dominant inheritance and excluded the LGR5 gene mutations as being involved in the pathogenesis of this condition.