[RISK FACTORS AND SPECIAL ASPECTS FORGENITAL TUBERCULOSIS DIAGNOSTICS].

Was examined 453 women, who applied to National Center for Tuberculosis and Lung Diseases for genital tuberculosis diagnostics. GTB was detected in 289 cases, in 164 cases GTB results was negative (control group). In 10 cases GTB was combined with pulmonary tuberculosis (OR-1,13). Risk factors are previous diseases of female reproductive organs- intracellular infection (OR-1,08), sexually transmitted diseases (OR-1,25), nonspecific inflammatory diseases (OR-1,009), interruption of pregnancy (OR-1,26), artificial abortions (OR-1,11), the most specific signs of Genital Tuberculosis is a pain in the stomach area (P-0,023), dysmenorrhoea (P-0,00001), intestinal obstruction (P-0,0006), heat (P-0,00001), liquid presence in posterior vault (P-0,007), hydrosalpinx (P-0,00001), Fallopian tubes deformation (P-0,000003), oophoritic cyst (P-0,067), adhesive process in small pelvis (P-0,0006). Lab tests used to study material showed high specificity of cytological (Sp - 78,05%), bacteriological (Sp - 96.4%) and morphological (Sp - 98.78%) methods, as a result of their low sensitivity (Se - 28.03%, 96.4%, 98.78%, respectively). As for PCR diagnostics, in this case both the sensitivity and specificity is of high level (Se - 77.98%, Sp - 82.11%).

[Genital tuberculosis--etiologically proved case report].

We report a clinical case of 36 year old woman with genital tuberculosis, who had no correct diagnosis and treatment for nine months. The etiological diagnosis was set after good collaboration between gynaecologists and microbiologists who had been looking for tuberculosis very active. The laboratory identification was based on conventional and new generation methods: fully automated system and modern molecular tests. The patient responded to anti-tuberculosis therapy and her condition improved.

Vaginal tuberculosis in an elderly kidney transplant recipient.

Female genital tuberculosis (FGTB) is extremely rare in post-menopausal women. A 59-year-old woman developed vaginal tuberculosis one year after receiving a kidney transplant from a living donor. Her complaints included abdominal pain, fever, and weight loss. Furthermore, her tuberculin skin test was negative. She was successfully treated with quadruple anti-TB therapy for 6 months.

Vulval lymphoedema following pulmonary tuberculosis.

Acquired lymphoedema of the vulva is induced by impaired lymph flow. We present the case of a 35-year-old woman having lymphoedema of the vulva following pulmonary tuberculosis, which she had developed four years back for which she had taken a full course of antitubercular treatment for nine months from the Chest and Tuberculosis department. The biopsy taken from the perianal swellings showed hyperkeratosis and acanthosis with multiple dilated lymph specs.

Genital tuberculosis in a tamoxifen-treated postmenopausal woman with breast cancer and bloody vaginal discharge.

BACKGROUND: Female genital tuberculosis is an uncommon disease that is rarely diagnosed in developed countries. CASE PRESENTATION: A 61-year-old postmenopausal woman who had undergone surgery and treated with adjuvant chemotherapy for infiltrating ductal carcinoma of the breast five years ago, presented with bloody vaginal discharge, fatigue, weight loss, and low grade fevers at night for two months. Histological examination of the endometrium, done based on the suspicion of a second primary cancer due to the tamoxifen therapy, revealed a granulomatous reaction. Liquid and solid mycobacterial cultures of the tissues were performed. Although the acid fast staining was negative, the liquid culture was positive for Mycobacterium tuberculosis. Involvement of other systems was not detected. The patient was treated with a three-drug antituberculosis regimen for 9 months and recovered fully. CONCLUSION: Female genital tuberculosis is a rare but curable disease that should be included in the differential diagnosis of women with menstrual problems. Early diagnosis is important and may prevent unnecessary invasive procedures for the patient.

Juvenile fulminant adnexal tuberculosis caused by gastrointestinal tuberculosis immediately after ovarian cystectomy.

Genital fulminant tuberculosis is rarely a primary site of infection. We report a case of juvenile adnexal tuberculosis possibly related to tuberculosis immediately after cystectomy in the ileocecal region in a virginal girl. A 13-year-old virginal girl visited our clinic because of a huge ovarian tumor, which was resected by cystectomy. On postoperative day 39, fever episodes were noted, and she received antibiotics, which were not effective. An abscess developed in the region of the cecum and the right adnexa. Laparotomy revealed chronic abscess formation, especially in the right adnexa. Resection of the abscess was done. The pathological diagnosis was tuberculosis with caseation, although bacterial culture and molecular biological diagnosis for Mycobacterium tuberculosis were negative in sputum, vaginal discharge, urine, and stool of the patient and her family. She was placed on anti-tuberculosis drugs, including isoniazid, rifampicin, and ethambutol, and this regimen was effective. This patient represents a rare case of fulminant adnexal tuberculosis without pulmonary disease.

Tuberculosis genital femenina

La tb genital casi siempre es secundaria a un foco primario localizado en área pulmonar, renal, intestinal, o peritoneal. Es rara la producida por el bacio tuberculoso bovino originado por la ingestión de leche contaminada. La vía de diseminación es la hemática en el 90 por ciento de casos iniciandose en el endosalpinx la misma que casi siempre es asintomática, es de descubrimiento causal al realizar un protocolo de esterilidad. El examen físico y el chequeo ginecológico no es concluyente a excepción de la Tb avanzada en donde se puede palpar masas abdominales difusas o con presencia de ascitis.

Endometrial tuberculosis acquired by a health care worker in a clinical laboratory.

I describe a case of endometrial tuberculosis acquired by a microbiologist while she was working in a clinical laboratory. Granulomatous endometritis was found, and Mycobacterium tuberculosis was isolated. Respiratory tract exposure from a faulty exhaust hood is the likely source of infection. Endometrial tuberculosis and laboratory-acquired infections are briefly discussed.

Primary tuberculous chancre in a renal transplant patient.

A case of primary tuberculous chancre of the vulva is reported. Although a tuberculous infection in an immunocompromised patient is not uncommon, this is the first report of a primary tuberculous infection on the external genitalia in such a patient. The source of infection in this patient could not be determined.

[Sarcoid reaction to a foreign body located in the uterus and the liver]. / Réaction sarcoïdosique à corps étranger localisée à l'utérus et au foie.

A case is reported of a sarcoidosis reaction within the uterine wall which developed following the vaginal injection of an unknown substance for contraceptive purposes. The reaction spread through the body to affect the lymphnodes and liver. Can this serve as an experimental model for the various forms of sarcoidosis observed clinically, notably genital sarcoidosis?