Synthesis of Cu and Zr-based coordination polymers with N/O donors and investigation of their photocatalytic activity against dye.

The coordination polymers (CPs) of Cu and Zr were synthesized by the hydrothermal method. The orotic acid potassium salt (H3KL) was used as a linker, which coordinates via O-O. Whereas, 4,4'-trimethylenedipyridine (4,4'-TMDP) was used as a bifunctional monomer, which coordinates via N-N. The synthesized CPs were characterized by FTIR, P-XRD, TGA, DSC and SEM. The photocatalytic activity was investigated against methylene blue (MB) under sunlight irradiation. Both Cu-CP and Zr-CP exhibited potential activity for the degradation of MB, which was 72 % for Cu-CP and 93 % for Zr-CP. The band gap of the CPs was also investigated, and the observed value was 2.2 eV. The band gap indicates that these compounds could bring breakthroughs as photocatalysts instead of semiconductors. These kinds of CPs could be used for multiple purposes in industry and in a green environment.

Pharmacological effect of Heritiera fomes on Long Evans rats against Postprandial Hyperglycemia and adsorption in vitro.

Background: Natural restoratives from traditional medicinal plants are considered to be a convenient, potent, and risk-free substitute treatment for hyperglycaemia. Our objective was to explore the activity of the crude extract of Heritiera fomes on postprandial hyperglycaemia by assessing relative measurements in a laboratory animal model. Methods: The Streptozotocin induced diabetic rat (n = 88, twenty-two per group) was used for the glucose tolerance test as an initial support for the study. BaSO4 was administered orally as a marker to measure gut motility after one hour of methanolic extract (500 mg/kg body weight) administration where, only purified water (10 ml/kg) was used to treat the control group (n = 12) and a dose (500 mg/kg) of H. fomes extract was used for the test group (n = 12 in each group). After 60 min of incubation of the mixture of extract and glucose with 10% (v/v) yeast cell suspension, the absorbance was measured to determine the capacity of glucose absorption by yeast cells. Sixty Long Evans rats (n = 12 in each group) were used to assess disaccharidase enzyme activity as µmol/mg protein per hour by Lowry's protein estimation method. The carbohydrate absorption investigation was executed to evaluate the leftover sucrose content in the gastrointestinal system (n = 64). Results: After oral administration of MHFL (71.84%), MHFB (71.41%), and MHFR (72.55%), GI motility (%) increased significantly (p < 0.001) compared to the control group (59.06%). A significant increase in glucose uptake and adsorption capacity measured by different concentrations of glucose ensures the decrease of glucose bound rate and a significant drop in blood glucose concentration. The significant (p < 0.001) decrease in intestinal disaccharidase activity of MHFL (1.40), MHFB (1.36), and MHFR (1.20) in comparison to the control group (1.50) indicates that the presence of H. fomes may reduce glucose absorption in the small bowel. Significant (p < 0.001 & p < 0.05) accumulation of sucrose content in the six different parts of the GI tract suggests the absorption of sucrose was decreased. Conclusions: The findings of this study provide evidence on probable mechanisms for the anti-diabetic characteristics of H. fomes, and it is predicted that this plant will be studied further for the development of strong anti-hyperglycemic medicines.