ABSTRACT
Improvements in the performance of small molecule-based organic solar cells have been reported through the use of a cyanopyridone acceptor group. This acceptor fragment enhances the absorbance of an oligothiophene-based dye and enables the addition of a solubilising alkyl chain that facilitates simple device fabrication from solution.
ABSTRACT
A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin.
Subject(s)
Antinematodal Agents/chemistry , Haemonchus/drug effects , Pyridazines/chemistry , Animals , Antinematodal Agents/chemical synthesis , Antinematodal Agents/pharmacology , Haemonchus/growth & development , Ivermectin/chemistry , Ivermectin/pharmacology , Larva/drug effects , Pyridazines/chemical synthesis , Pyridazines/pharmacology , Structure-Activity RelationshipABSTRACT
A series of hydrazonotrifluorosulfonanilide derivatives were synthesized and evaluated for in vitro activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. Some compounds with excellent activity against tick were identified.
Subject(s)
Antiparasitic Agents/chemistry , Hydrazones/chemistry , Sulfonamides/chemistry , Animals , Antiparasitic Agents/chemical synthesis , Antiparasitic Agents/pharmacology , Cats , Dogs , Drug Discovery , Hydrazones/chemical synthesis , Hydrazones/pharmacology , Rhipicephalus sanguineus/drug effects , Structure-Activity Relationship , Sulfonamides/chemical synthesis , Sulfonamides/pharmacologyABSTRACT
A series of novel 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilide derivatives have shown significant in vitro parasiticidal activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. A number of these compounds also displayed significant in vitro endoparasite activity against the nematode Haemonchus contortus.
Subject(s)
Antiparasitic Agents/chemistry , Antiparasitic Agents/pharmacology , Rhipicephalus sanguineus/drug effects , Siphonaptera/drug effects , Sulfonamides/chemistry , Sulfonamides/pharmacology , Animals , Haemonchus/drug effects , Structure-Activity RelationshipABSTRACT
A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites.