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Objective: Social isolation and loneliness are associated with poor health (immunity, inflammation, etc.) in ageing. The purpose of this scoping review was to investigate the link between social isolation, loneliness (as distinct constructs, in contrast to previous published work) and cognition in cognitively healthy older adults. Method: We followed PRISMA-ScR guidelines. Our search, conducted between January 2017 and April 2021, yielded 2,673 articles, of which, twelve longitudinal studies were finally identified as meeting the inclusion criteria. Multiple cognitive functions (short-term and episodic memory, attention, and global cognitive functioning) were measured. Results: The results showed that both social isolation and loneliness were associated with poor cognition in ageing, with depression as a possible mediator between loneliness and poor cognition. Some studies also suggested that the link between social isolation, loneliness and cognitive decline may be bidirectional. Conclusion: We conclude that both social isolation and loneliness may have a different impact on cognition. While depression may be an important mediator between loneliness and cognitive decline, the lack of cognitive stimulation may be a greater mediator between social isolation and cognitive health.
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Several clinical scales have been developed to assess the severity of bronchiolitis as well as the probability of needing in-hospital care. A recent systematic review of 32 validated clinical scores for bronchiolitis concluded that 6 of them (Wood-Downes, M-WCAS, Respiratory Severity Score, Respiratory Clinical Score, Respiratory Score and Bronchiolitis risk of admission score) were the best ones regarding reliability, sensitivity, validity, and usability. However, to the best of our knowledge, no study has compared all of them in a clinical scenario. Also, after this review, three more scales were published: BROSJOD, Tal modified, and one score developed by PERN. Our main aim was to compare the ability of different clinical scales for bronchiolitis to predict any relevant outcome. A prospective observational study was conducted that included patients of up to 12 months old attended to, due to bronchiolitis, in the paediatric Emergency Department of a secondary university hospital from October 2019 to January 2022. For each patient, the attending clinician filled in a form with the items of the scales, decomposed, in order to prevent the clinician from knowing the score of each scale. Then, the patient was managed according to the protocol of our Emergency Department. A phone call was made to each patient in order to check whether the patient ended up being admitted in the next 48 h. In the case of those that were impossible to contact by phone, the clinical history was reviewed. For the purpose of the study, any of the following were considered to be a relevant outcome: admission to ward and need for supplementary oxygen, non-invasive ventilation (NIV) or intravenous fluids, and admission to the paediatric intensive care unit (PICU) within the next 48 h or death. For the aim of the study, the area under the curve (AUC) and the odds ratio (OR) for a relevant outcome were calculated in each scale. Also, the best cut-off point was estimated according to the Youden index, and its sensitivity (Sn) and specificity (Sp) for a relevant outcome were calculated. We included 265 patients (52.1% male) with a median age of 5.3 months (P25-P75 2.6-7.4). Among them, 46 (17.4%) had some kind of relevant outcome. AUC for prediction of a relevant outcome ranged from 0.705 (Respiratory Score) to 0.786 (BRAS), although no scale performed significantly better than others. A score ≤ 2 in the PERN scale showed a sensitivity of 91.3% (CI95% 79.7-96.6) for a relevant outcome, with only 4 misdiagnosed patients (only 2 of them needed NIV). Conclusions: There were no differences in the performance of the nine scales to predict relevant outcomes in patients with bronchiolitis. However, the PERN scale might be more useful to select patients at low risk of a severe outcome. What is Known: ⢠Several clinical scales are used to assess the severity of bronchiolitis. Nevertheless, none of them seems to be better than others. What is New: ⢠This is the first study comparing different bronchiolitis scales in a real clinical scenario. None of the nine scales compared performed better than the other. However, the PERN scale might be more useful to select patients at low risk of relevant outcomes.
Subject(s)
Bronchiolitis , Noninvasive Ventilation , Child , Humans , Male , Infant , Female , Reproducibility of Results , Bronchiolitis/diagnosis , Bronchiolitis/therapy , Hospitalization , Respiration, Artificial/methods , Noninvasive Ventilation/methods , Observational Studies as TopicABSTRACT
OBJECTIVE: The cognitive characterization of Alzheimer's disease risk states, such as amnestic mild cognitive impairment (aMCI) and subjective cognitive decline (SCD), is fundamental for timely diagnosis and interventions. The Face Name Associative Memory Exam (FNAME) is sensitive to early Alzheimer's disease brain changes, and an extended version captures a fuller range of associative memory abilities. We aimed to assess group effects in the extended FNAME in older adults with SCD, aMCI, and older adult controls (CON). METHOD: Two concurrently created versions of the extended FNAME were used to test three groups of older adults (CON = 35, SCD = 37, aMCI = 31) at two sites (Mexico = 59, Netherlands = 44). Extended FNAME memory abilities were analyzed in five analyses of variance. Group and site were considered as independent variables. For the recall ability, subtest levels were entered as a within-subject variable. The remaining abilities (Face Recognition, Name Recognition, Spontaneous Name Recall, and Face-Name Matching) were analyzed in independent models. RESULTS: In all models, the main effect for group was significant with large effect sizes, driven by a worse performance of aMCI participants. No significant differences were found between SCD and CON. The main effect for site was only significant in Face Recognition. CONCLUSIONS: The worse performance of aMCI in the extended FNAME implies an impairment in associative memory abilities beyond recall. The similar performance of CON and SCD might be explained by the recruitment of SCD participants that did not spontaneously seek help for memory decline. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Subject(s)
Alzheimer Disease , Cognitive Dysfunction , Humans , Aged , Alzheimer Disease/diagnosis , Neuropsychological Tests , Cognition , Cognitive Dysfunction/diagnosis , Recognition, PsychologyABSTRACT
Objective: Memory impairment is a hallmark cognitive deficit in Parkinson's disease (PD). However, it remains unclear which processes underlie this deficit in PD. Also, little is known on these patients' subjective experiences of memory difficulties and their relationship with objective measures. We aim to portray memory deficits in PD by combining objective and subjective memory measures. Methods: Fifteen PD patients and 15 controls were assessed with an extended version of the Face-Name Associative Memory Exam (FNAME) and the Memory Failures of Everyday Questionnaire (MFE-28). We also explored the relationship among clinical and cognitive variables. Results: Participants with PD presented with more memory complaints. On the FNAME, these patients exhibited lower performance in free recall, as well as in name recognition and matching. Importantly, when controlling for initial learning, group effects disappeared, except for matching. Associative memory therefore was significantly compromised in PD and correlated with subjective memory complaints (SMC). Conclusion: Our findings suggest that associative memory may constitute a sensitive measure to detect subtle memory deficits in PD. Moreover, the current study further clarifies the source of memory impairment in PD. Thus, our study highlights the clinical value of including associative memory tests such as the FNAME in PD neuropsychological assessment.
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Evidence shows that participants performing a continuous visual categorization task respond slower following the presentation of a task-irrelevant sound deviating from an otherwise repetitive or predictable auditory context (deviant sound among standard sounds). Here, for the first time, we explored the role of the environmental context (instrumentalized as a task-irrelevant background picture) in this effect. In two experiments, participants categorized left/right arrows while ignoring irrelevant sounds and background pictures of forest and city scenes. While equiprobable across the task, sounds A and B were presented with probabilities of .882 and .118 in the forest context, respectively, and with the reversed probabilities in the city context. Hence, neither sound constituted a deviant sound at task-level, but each did within a specific context. In Experiment 1, where each environmental context (forest and city scene) consisted of a single picture each, participants were significantly slower in the visual task following the presentation of the sound that was unexpected within the current context (context-dependent distraction). Further analysis showed that the cognitive system reset its sensory predictions even for the first trial of a change in environmental context. In Experiment 2, the two contexts (forest and city) were implemented using sets of 32 pictures each, with the background picture changing on every trial. Here too, context-dependent deviance distraction was observed. However, participants took a trial to fully reset their sensory predictions upon a change in context. We conclude that irrelevant sounds are incidentally processed in association with the environmental context (even though these stimuli belong to different sensory modalities) and that sensory predictions are context-dependent.
Subject(s)
Attention , Auditory Perception , Humans , Acoustic Stimulation , Reaction Time , SoundABSTRACT
It has been established that participants performing a continuous categorization task respond significantly slower following the presentation of unexpected, task-irrelevant, auditory stimuli, compared to a repetitive (standard) sound. Evidence indicates that such distraction emerges because of the violation of sensory predictions. This has typically been studied by measuring the impact of replacing the repeated sound by a different sound on rare and unpredictable trials. Here, we examine the impact of a different type of violation: the mere omission of the standard sound. Capitalizing upon the recent finding that deviant sounds exert distinct effects on response times as a function of whether participants produced or withheld a response on the previous trial, we present the results of an experiment seeking to disentangle two potential effects of sound omission: deviance distraction and the removal of an unspecific warning signal. The results indicate that deviant sound and the unexpected omission of the standard sound impact response times through, at least partially, distinct mechanisms. Deviant sounds affect performance by triggering the orienting of attention towards a new sensory input. Sound omissions, in contrast, appear to affect performance in part because responses no longer benefit from an unspecific warning signal to prepare for action.
Subject(s)
Auditory Perception , Sound , Acoustic Stimulation , Attention/physiology , Auditory Perception/physiology , Humans , Reaction Time/physiologyABSTRACT
OBJECTIVE: The ability to recognize emotions from facial expression (FER) may be impaired in Parkinson's disease (PD). We aimed to explore FER in PD patients by using a dynamic presentation of emotions across different intensities and to examine the extent to which executive and affective alterations contributed to FER deficits. METHOD: Fifteen PD patients and 15 healthy controls were assessed on the emotion recognition task (ERT). We also explored how clinical and executive factors could have contributed to ERT accuracy. RESULTS: PD patients showed poorer performance on the ERT, specifically on angry expressions, but they benefited from increased intensity as much as controls did. Differences were also found for apathy, depression, and executive tests, especially in the inhibition domain. Importantly, differences between groups on the ERT disappeared when controlling for inhibition and the affective symptoms. A significant effect of inhibition dysfunction was also observed on the ERT performance. CONCLUSIONS: Our findings demonstrate the presence of emotion recognition deficits of morphed facial expressions in patients with PD. Moreover, they suggest that inhibition dysfunctions may act as an important factor negatively influencing FER. The present study highlights the complex nature of emotion processing and its relation with emotional-affective and cognitive aspects to provide a better understanding of FER deficits in PD. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Subject(s)
Facial Recognition , Parkinson Disease , Emotions/physiology , Facial Expression , Facial Recognition/physiology , Humans , Neuropsychological Tests , Parkinson Disease/complications , Parkinson Disease/psychologyABSTRACT
It is well-established that task-irrelevant sounds deviating from an otherwise predictable auditory sequence capture attention and disrupt ongoing performance by delaying responses in the ongoing task. In visual tasks, larger distraction by unexpected sounds (deviance distraction) has been reported in older than in young adults. However, past studies based this conclusion on the comparisons of absolute response times (RT) and did not control for the general slowing typically observed in older adults. Hence, it remains unclear whether this difference in deviance distraction between the two age groups reflects a genuine effect of aging or a proportional effect of similar size in both groups. We addressed this issue by using a proportional measure of distraction (PMD) to reanalyze the data from four past studies and used Bayesian estimation to generate credible estimates of the age-related difference in deviance distraction and its effect size. The results were unambiguous: older adults exhibited greater deviance distraction than young adults when controlling for baseline response speed (in each individual study and in the combined data set). Bayesian estimation revealed a proportional lengthening of RT by unexpected sounds that was about twice as large in older than in young adults (corresponding to a large statistical effect size). A similar analysis was carried out on the proportion of correct responses (PC) and produced converging results. Finally, an additional Bayesian analysis comparing data from cross-modal and uni-modal studies confirmed the selective effect of aging on distraction in the first and not the second. Overall, our study shows that older adults performing a visual categorization task do exhibit greater distraction by unexpected sounds than young adults and that this effect is not explicable by age-related general slowing.
ABSTRACT
INTRODUCTION: The Face Name Associative Memory Exam (FNAME) is sensitive to associative memory changes early in the Alzheimer's disease spectrum, but little is known about how healthy aging affects FNAME performance. We aimed to assess aging effects on an extended version of the test, which captures further associative memory abilities beyond the recall and recognition domains measured in the original version. METHOD: We adapted FNAME versions in Spain and Mexico, adding new subtests (Spontaneous Name Recall, Face-Name Matching). We compared the performance of 21 young adults (YA) and 27 older adults (OA) in Spain, and 34 YA and 36 OA in Mexico. Recall was analyzed using a mixed-model ANOVA including subtest scores as dependent variables, age group as a fixed-factor independent variable, and recall subtest as a three-level repeated-measure independent variable. The rest of the associative memory domains were analyzed through t-tests comparing the performance of YA and OA. RESULTS: In Spain, we found significant effects for age group and recall subtest, with large effect sizes. The recognition subtests (Face Recognition, Name Recognition) displayed ceiling effects in both groups. The new subtests displayed medium-to-large effect sizes when comparing age groups. In Mexico, these results were replicated, additionally controlling for education. In both studies, recall performance improved after repeated exposures and it was sustained after 30 minutes in YA and OA. CONCLUSIONS: We document, in two different countries, a clear aging pattern on the extended FNAME: regardless of education, OA remember fewer stimuli than YA through recall subtests. The new subtests provide evidence on associative memory changes in aging beyond recall.
Subject(s)
Memory , Names , Aged , Humans , Mental Recall , Mexico , Neuropsychological Tests , SpainABSTRACT
PURPOSE: Serious complications after ultrasound-guided regional anaesthesia can be devastating for the patient. The pathogenesis of postoperative neurological complications (PONC) is multifactorial and includes mechanical, vascular and chemical factors besides the nerve puncture itself. The primary aim of this study was to assess the incidence of PONC after brachial plexus block (BPB). METHODS: This is an observational retrospective single-centre study conducted at the regional anaesthesia unit of a teaching hospital. All BPBs performed from January 2011 to November 2019 were included. The outcomes analysed were the incidence, aetiology and diagnosis of PONCs and the incidence of other postoperative complications such as local anaesthetic systemic toxicity (LAST), pneumothorax, wrong-side block, etc. The performance of trainees and experienced anaesthesiologists was compared across all the outcomes. RESULTS: From a total of 5340 BPBs included, 15 cases developed PONC, yielding a rate of 2.81:1000 (95% CI 1.70-4.63). Thirteen patients underwent neurophysiological exams which confirmed nine neuropathies. The rate of PONCs for supervised trainees was 1.80:1000 (95% CI 0.701-4.62), not statistically different from that of experienced anaesthesiologists (p = 0.241). Three cases were considered to present with a PONC probably related to BPB [0.562:1,00 (95% CI 0.191-1.65)]. The incidence of long-term PONCs was 1.12:1000 (95% CI 0.515-2.45). Such complications proved irreversible in 2 cases. The incidences of LAST, pneumothorax and other complications observed were 0.749:1000 (95% CI 0.291-1.92), 0.187:1000 (95% CI 0.0331-1.06) and 4.31:1000 (95% CI 2.87-6.46), respectively. CONCLUSIONS: This survey suggests that complications after ultrasound-guided BPB, including blocks performed by trainees, are uncommon. TRIAL REGISTRATION: Clinicaltrials.gov ID: NCT04451642.
Subject(s)
Brachial Plexus Block , Brachial Plexus , Anesthetics, Local , Brachial Plexus/diagnostic imaging , Brachial Plexus Block/adverse effects , Hospitals, Teaching , Humans , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Retrospective Studies , Ultrasonography, InterventionalABSTRACT
BACKGROUND: Homeless population has been severely affected by the COVID-19 pandemic. Their living conditions, comorbidity with different pathologies and a greater frequency of mental disorders, make this population vulnerable. METHOD: We implemented a program of serial visits in a hostel for confined homeless of the city council social services, for the monitoring and treatment of mental disorders and substance abuse problems. Accompanied by serial phone and email contacts. RESULTS: A highly significant percentage (63%) had mental disorders or substance abuse, requiring pharmacological intervention, and 37% began follow-up in resources of the Mental Health and Addiction network of the Psychiatric Service at the end of the program. Hospital emergency service visits were drastically reduced. None of them were infected with COVID-19. An individualized Social plan was drawn up in order to reintegrate them with support in the community. CONCLUSIONS: The Results have been really positive, meeting all the objectives and opening up developing new programs in the future, in the pandemic outbreak and out of it.
Subject(s)
COVID-19/prevention & control , Community Mental Health Services/organization & administration , Ill-Housed Persons/psychology , Mental Disorders/therapy , Substance-Related Disorders/therapy , Adult , Drug Therapy , Female , Humans , Male , Program Evaluation , Psychotherapy , Spain , Vulnerable PopulationsABSTRACT
OBJECTIVE: The source of episodic memory (EM) impairment in Parkinson's disease (PD) is still unclear. In the present study, we sought to quantify specifically encoding, consolidation, and retrieval process deficits in a list-learning paradigm by a novel method, the item-specific deficit approach (ISDA). METHODS: We applied the ISDA method to the Free and Cued Selective Reminding Test (FCSRT) in a sample of 15 PD patients and 15 healthy participants. RESULTS: The results revealed differences in free recall performance between PD patients and controls. These patients, however, benefited from cues as much as controls did, and total recall did not differ between groups. When analyzing the ISDA indices for encoding, consolidation, and retrieval deficits, the results showed a general memory deficit, but with a clear focus on encoding and retrieval, as revealed by the sensitivity values. Moreover, controlling for initial learning did not eliminate group effects in retrieval. CONCLUSIONS: Our findings reveal a mixed pattern in PD patients, with deficits in both encoding and retrieval processes in memory. Also, despite the fact that an encoding dysfunction may explain some of the deficits observed at retrieval, it cannot fully account for the differences, highlighting that both encoding and retrieval factors are necessary to understand memory deficits in PD.
Subject(s)
Memory, Episodic , Parkinson Disease , Humans , Memory Disorders/etiology , Mental Recall , Neuropsychological Tests , Parkinson Disease/complicationsABSTRACT
The COVID-19 pandemic reached world-wide causing a great impact on healthcare services. The aim of this work is to describe the response of the Mental Health Network of the Salamanca´ Area (Spain) to this crisis and the reorganization of its resources within the first 8 weeks after the state of alarm was declared. The Psychiatry Service applied a contingency plan which included the reorganization of the human resources, the closure of some of the units and the implementation of telemedicine programs along with two specific programs, namely a mental health assistance program in the context of the infection by coronavirus, and another program for homeless people. 9.038 phone interviews were carried out in the outpatients and community mental health programs. The activity in subacute and acute wards, as well as that of the day hospital programs was decreased to 50%. Based on that this real-world response provided we concluded that the usage of telemedicine is promising in patients with any kind of disorder. Its implementation in daily practice will be considered in the future. Research must continue on COVID-19's impact on patients with mental disorders and Psychiatry's necessary adaptations and new approaches to them.
Subject(s)
Coronavirus Infections/psychology , Mental Disorders/therapy , Mental Health Services , Mental Health , Pneumonia, Viral/psychology , Telemedicine , Betacoronavirus , COVID-19 , Humans , Mental Disorders/psychology , Outpatients , Pandemics , SARS-CoV-2 , SpainABSTRACT
OBJECTIVE: The present study seeks to provide an overview of executive (inhibition and flexibility) deficits in Parkinson's disease (PD) by combining a cognitive and behavioral approach. METHODS: Fifteen PD patients and 15 healthy controls underwent a neuropsychological and behavioral assessment including the Hayling and Trails Tests, the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP-RS), the Behavior Rating Inventory of Executive Function (BRIEF-A), and the Short Form-36 Health Survey (SF-36). The level of awareness of executive functioning was also analyzed. We finally explored how these neuropsychological and clinical outcomes could relate to each other. RESULTS: PD patients performed significantly worse in both neuropsychological tasks designed to evaluate inhibition abilities. They also reported more inhibition difficulties in everyday life and poorer quality of life. Associations between neuropsychological measures and self-reports were found. Moreover, as indicated by the discrepancy score, PD patients were as accurate as their relatives in self-reporting their executive daily difficulties. CONCLUSION: Inhibition and cognitive flexibility impairments assessed by the neuropsychological tests (Hayling and Trails tests) seem to capture daily life executive problems in PD. Furthermore, our study provides a deeper understanding of PD patients' and their relatives' experience of these executive dysfunctions.
ABSTRACT
The present study examined the effects of mindfulness on depression and anxiety, both direct and indirect through the mediation of four mechanisms of emotional regulation: worry, rumination, reappraisal and suppression. Path analysis was applied to data collected from an international and non-clinical sample of 1151 adults, including both meditators and non-meditators, who completed an online questionnaire battery. Our results show that mindfulness are related to lower levels of depression and anxiety both directly and indirectly. Suppression, reappraisal, worry and rumination all acted as significant mediators of the relationship between mindfulness and depression. A similar picture emerged for the relationship between mindfulness and anxiety, with the difference that suppression was not a mediator. Our data also revealed that the estimated number of hours of mindfulness meditation practice did not affect depression or anxiety directly but did reduce these indirectly by increasing mindfulness. Worry and rumination proved to be the most potent mediating variables. Altogether, our results confirm that emotional regulation plays a significant mediating role between mindfulness and symptoms of depression and anxiety in the general population and suggest that meditation focusing on reducing worry and rumination may be especially useful in reducing the risk of developing clinical depression.
ABSTRACT
INTRODUCTION: In the present study, we use the item-specific deficit approach (ISDA), a method for characterizing memory deficits in list-learning, to portray the memory deficits in amnestic mild cognitive impairment (aMCI). METHODS: We applied the ISDA to compare memory performance of patients with aMCI and healthy controls in encoding, consolidation, and retrieval using the Free and Cued Selective Reminding Test. RESULTS: The results revealed clear differences in recall performance between patients with aMCI and controls. When analyzing the ISDA deficit indices, the results revealed a prominent encoding deficit, followed by a consolidating deficit. A greater sensitivity for the encoding index confirmed that a difficulty with encoding information plays a major role in explaining the episodic memory deficits experienced by patients with aMCI. DISCUSSION: The present study applying the ISDA reveals great sensitivity and specificity of the encoding deficit index when identifying aMCI. As aMCI constitutes a risk factor to develop Alzheimer's disease, the current findings also confirm the need to concentrate on encoding deficits as an early diagnostic sign of cognitive decline.
ABSTRACT
Biochar is a high carbon material resulting from biomass pyrolysis that, when applied to croplands, can increase soil carbon and soil water retention. Both effects are of critical importance in semi-arid regions, where carbon decline and desertification are the main drivers of soil degradation. Since most environmental services provided by soil are mediated by belowground biota, effects of biochar on soil microbial and invertebrate communities must be evaluated under field conditions before its agricultural application can be recommended. We tested maize biochar for its mid-term effect on soil microbes and micro-arthropods of a Mediterranean vineyard. We applied biochar to three field plots with neutral sandy loam soils at a dose of 5â¯Mgâ¯ha-1. During two years, we monitored the abundance of functional groups of soil micro-arthropods and estimated the biomass of soil microbial groups. We also analyzed the δ13C value of microbial PLFA biomarkers to determine biochar-C utilization by each microbial group taking advantage of the δ13C natural abundance differences between the applied biochar and the soil. Biochar addition significantly reduced soil microbial biomass but did not alter the functional microbial diversity nor the abundance or biodiversity of soil micro-arthropods. The contribution of biochar-C to the diet of most microbial groups was very low through the monitoring period. However, two gram-negative bacterial groups increased their biochar-derived carbon uptake under extreme soil dryness, which suggests that biochar-C might help soil microbes to overcome the food shortage caused by drought. The decrease in microbial biomass observed in our experiment and the concomitant decrease of SOM mineralization could contribute to the carbon sequestration potential of Mediterranean soils after biochar addition.
Subject(s)
Charcoal/chemistry , Farms , Soil Microbiology , Soil/chemistry , Animals , Arthropods/classification , Arthropods/physiology , Biomass , Mediterranean Region , Population Density , Zea maysABSTRACT
Performance in sustained attention tasks is known to be slowed by the occurrence of unexpected task-irrelevant distractors (novelty distraction) and the detection of errors (posterror slowing), 2 well-established phenomena studied separately and regarded as reflecting distinct underpinning mechanisms. We measured novelty distraction and posterror slowing in an auditory-visual oddball task to test the hypothesis that they both involve an orienting response. Our results confirm that the 2 effects exhibit a positive interaction. We show that a trial-by-trial measure of surprise credibly accounts for our empirical data. We suggest that novelty distraction and posterror slowing both reflect an orienting response to unexpected events and a reappraisal of action plans. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
Subject(s)
Attention/physiology , Auditory Perception/physiology , Psychomotor Performance/physiology , Reaction Time/physiology , Visual Perception/physiology , Adolescent , Adult , Female , Humans , Male , Young AdultABSTRACT
One current challenge for neuropsychologists is to design assessment methods capable of detecting cognitive deficits in the early or preclinical phases of Alzheimer's disease (AD). The objective of this paper is to review the studies that have explored the use of the Face-Name Associative Memory Exam (FNAME) as a test for early diagnosis of AD. Studies looking at correlations between performance on the FNAME test and biomarkers in healthy people and studies comparing healthy controls and people with mild cognitive impairment are reviewed. These studies are based on the evidence that AD's pathological process begins years before the most visible clinical manifestations. We conclude that the FNAME test may be a valuable tool for early diagnosis but that some important questions remain to be resolved in future research.
ABSTRACT
Chronic aerobic exercise is being established as a way to enhance executive functions and prevent cognitive decline. In the current study, we are aiming to investigate whether chronic aerobic exercise would also modulate long-term memory retrieval under the context of the Retrieval Practice Paradigm. According to Anderson et al. (1994), the retrieval of relevant information may decrease the access to other related information inducing the failure to remember or forgetting Interestingly, it has been shown (Román et al., 2009) that this process is mediated by the level of attentional resources. In order to test if chronic aerobic exercise benefits attentional resources, we have applied the Dual Retrieval Practice Task. The purpose of this task is to evaluate the Retrieval Induced Forgetting (RIF) effect, which is supposed to index adaptive forgetting. More specifically, the Dual Retrieval Practice Task assesses the effects of memory retrieval on forgetting information directly related to the information that has been previously retrieved, but also studies the involvement of attentional resources on this type of forgetting (retrieval induced forgetting). This task alternates memory retrieval practice with an updating task in order to load attentional resources. Two groups of physically active and sedentary young participants were evaluated. The results showed that while active participants were able to show RIF despite the overload of the attentional resources, sedentary participants were not. These results are discussed in terms of the modulatory role of chronic aerobic exercise on executive control and retrieval induced forgetting.