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Chem Commun (Camb)
; 57(63): 7778-7781, 2021 Aug 05.
Article
in English
| MEDLINE
| ID: mdl-34263896
ABSTRACT
Cyclative cleavage of an amine-carbamate self-immolative spacer to deliver a hydroxyl cargo was inhibited by spacer derivatisation with a phosphate monoester handle. This trifunctional spacer was installed in a model anticancer prodrug that showed fast drug release only when incubated with both a protease and a phosphatase enzyme.