ABSTRACT
A significant association with asymptomatic joint hypermobility was observed in 37 children with a history of infantile hypertrophic pyloric stenosis (P =.0016) and their parents (mothers, P <.0001; fathers, P <.05). The subjects with articular hypermobility showed an increased frequency of absent mandibular frenulum, thereby suggesting the presence of a previously unrecognized, systemic abnormality of the extracellular matrix.
Subject(s)
Joint Instability/complications , Pyloric Stenosis/complications , Extracellular Matrix/pathology , Female , Humans , Infant , Joint Instability/diagnosis , Male , Pyloric Stenosis/pathology , Pyloric Stenosis/surgeryABSTRACT
Among 25 patients with hypertrophic pyloric stenosis, a hypoplastic or absent mandibular frenulum was noted in 92%, compared with 1.6% of 319 control infants (P <.001). This previously unrecognized sign may prove helpful in identifying newborns at risk of developing the disorder.
Subject(s)
Labial Frenum/abnormalities , Pyloric Stenosis/complications , Female , Humans , Hypertrophy , Infant, Newborn , Male , Pyloric Stenosis/pathologyABSTRACT
Chorioamnionitis, a major cause of preterm birth with significant neonatal morbidity and mortality, frequently occurs in mothers who are free of symptoms. A combined clinical, radiologic, and pathologic study of 129 very low birth weight infants indicated a significant association between a markedly decreased thymic size at birth and subclinical chorioamnionitis.