Obese mice on a high-fat alternate-day fasting regimen lose weight and improve glucose tolerance.

Alternate-day fasting (ADF) causes body weight (BW) loss in humans and rodents. However, it is not clear that ADF while maintaining a high-fat (HF) diet results in weight loss and the accompanying improvement in control of circulating glucose. We tested the hypotheses that a high-fat ADF protocol in obese mice would result in (i) BW loss, (ii) improved glucose control, (iii) fluctuating phenotypes on 'fasted' days when compared to 'fed' days and (iv) induction of torpor on 'fasted days'. We evaluated the physiological effects of ADF in diet-induced obese mice for BW, heart rate (HR), body temperature (Tb ), glucose tolerance, insulin responsiveness, blood parameters (leptin, insulin, free fatty acids) and hepatic gene expression. Diet-induced obese male C57BL/6J mice lost one-third of their pre-diet BW while on an ADF diet for 10 weeks consisting of HF food. The ADF protocol improved glucose tolerance and insulin sensitivity, although mice on a fast day were less glucose tolerant than the same mice on a fed day. ADF mice on a fast day had low circulating insulin, but had an enhanced response to an insulin-assisted glucose tolerance test, suggesting the impaired glucose tolerance may be a result of insufficient insulin production. On fed days, ADF mice were the warmest, had a high HR and displayed hepatic gene expression and circulating leptin that closely mimicked that of mice fed an ad lib HF diet. ADF mice never entered torpor as assessed by HR and Tb . However, on fast days, they were the coolest, had the slowest HR, and displayed hepatic gene expression and circulating leptin that closely mimicked that of Chow-Fed mice. Collectively, the ADF regimen with a HF diet in obese mice results in weight loss, improved blood glucose control, and daily fluctuations in selected physiological and biochemical parameters in the mouse.

International standards for hospital communication systems.

A major problem for many Hospital Information Systems is separating modules to meet the information requirements of specialized parts before integration into one system. In most cases the interfaces are proprietary, leading to an enormous amount of implementation work for access to other systems. International Standards, such as a common language in Medical Communication, offer the possibility of reducing this variety and enhancing the information interchange by connecting more systems in shorter time with less cost.

RDA: a standard for client server communication in a hospital information system.

The University of Erlangen-Nürnberg contains a large medical faculty with many hospitals, laboratories, and other departments distributed in the town of Erlangen, and it is necessary to exchange medical data between them. For example the basic patient data which are held on central computers, must be distributed to various stations and departments. In addition medical reports which are prepared on or generated by computers in central departments must be transmitted to various points in the hospitals [1]. When the network, based on ethernet cabling within the hospitals and a glass fiber backbone, has been completed, the Erlangen hospital communication system will support an electronic exchange of medical information. Two separate communication methods are used: data exchange via electronic mail according to the international standard X.400 and remote access to central databases using the software product NET-WORK.

Dissemination of patient data in the Erlangen Hospital communication and information system.

It is necessary to exchange information between the various institutions of the medical faculty of the University of Erlangen-Nurnberg. For example, basic patient data, which is collected in a central computer, must be distributed to various stations and laboratories. Also medical findings, which are already captured in computers in central laboratories, must be transmitted to various parts of the university hospitals. After the data network, consisting of a glass fiber backbone linking the buildings and cabling in the individual departments, had been implemented, it became possible to provide an electronic exchange of medical information.