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J Pediatr ; 156(5): 771-6, 776.e1, 2010 May.
Article in English | MEDLINE | ID: mdl-20171652

ABSTRACT

OBJECTIVE: To evaluate parental stress after a false-positive result at the time of the cystic fibrosis (CF) newborn screening (NBS), attributable to heterozygotism or persistent hypertrypsinemia. STUDY DESIGN: A prospective study was conducted in 86 French families at 3, 12, and 24 months after NBS. A psychologist conducted interviews with a questionnaire, the Perceived Stress Scale, and the Vulnerable Child Scale. RESULTS: Overall, 96.5% of parents said they had been anxious at the time of the sweat test. However, 86% felt entirely reassured 3 months after the test. The mean Perceived Stress Scale score did not differ from that observed in the French population. Mean Vulnerable Child Scale scores were high, associated with a low Parental Perception of Child Vulnerability. These results did not differ significantly at 1 and 2 years. In total, 86% to 100% of families no longer worried about CF. All parents stated that they would have the test performed again for another child. CONCLUSIONS: CF NBS can lead to false-positive results, causing parental anxiety, which quickly decreases after a sweat test performed soon after the phone call.


Subject(s)
Cystic Fibrosis/diagnosis , Neonatal Screening/psychology , Parents/psychology , Anxiety/etiology , Cystic Fibrosis/psychology , Cystic Fibrosis Transmembrane Conductance Regulator/genetics , False Positive Reactions , Female , Heterozygote , Humans , Infant, Newborn , Male , Mutation , Sweat/chemistry , Trypsin/blood
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