ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection not only affects the respiratory system but also induces coagulation abnormalities and thrombosis. We report a middle-aged woman who presented during the Covid-19 pandemic with sudden-onset acute left upper limb ischaemia of short duration, with no history of dry cough, breathlessness or fever, and tested positive on TrueNAT for SARS-CoV-2. Later, she developed deep venous thrombosis of the right lower limb during isolation in the hospital.
Subject(s)
COVID-19 , Venous Thrombosis , Middle Aged , Female , Humans , COVID-19/complications , COVID-19/diagnosis , SARS-CoV-2 , Pandemics , Venous Thrombosis/diagnostic imaging , Venous Thrombosis/etiology , LegABSTRACT
Nuclear DNA content and cell cycle distribution in fresh tissues from 40 malignant and 10 benign breast tumors were assessed by flow cytometry using a DNA-specific fluorochrome, 4,6-diamidino-2phenyl-indole hydrochloride. DNA indices (DIs) (relative DNA content of tumor cells with reference to normal cells, 4,6-diamino-2phenyl-indole-hydrochloride ranged from 0.85 to 5.6 for malignant tumors and from 1.8 to 2.2 for benign tumors. Proliferating fraction (PF) (total cells in S and G2 + M phases) values were significantly higher in malignant tumors (35.4 +/- 14.75, mean +/- SD; P < .001) than in benign tumors (14.2 + 4.9) and adjacent normal tissues (6.6 + 2.73). DIs and cell cycle distribution correlated with clinicopathologic parameters, disease progression and survival. Four-year survival was greater in patients with a DI value of 1.8-2.2 as well as with SF values less than 10%.