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1.

[Biotransformation of alimemazine]. / Biotransformation von Alimemazin.

Pfeifer, S; Bornschein, I; Franke, P; Fischer, C.

Pharmazie ; 41(2): 111-3, 1986 Feb.

Article in German | MEDLINE | ID: mdl-3725848

ABSTRACT

After application of alimemazine (1) 14 phenothiazine derivatives were detected in the rat urine. The structure of 9 metabolites was elucidated (TLC detection, UV, MS), which are hydroxy, N-dealkyl, S-oxide, and sulfone derivatives of 1. The hydroxy compounds, which are the main metabolites (greater than 50%), are partly conjugated. 5-10% of sulfones were observed. Some of the metabolites were detected in the feces, too. The relationship of the excretion products in urine and feces is 75:25%.

Subject(s)

Trimeprazine/metabolism , Animals , Biotransformation , Chromatography, Thin Layer , Female , Rats , Rats, Inbred Strains , Trimeprazine/urine

2.

[Further sulfone metabolites of promethazine (Prothazin)]. / Weitere Sulfonmetaboliten des Promethazins (Prothazin).

Bornschein, I; Pfeifer, S.

Pharmazie ; 35(10): 648-9, 1980.

Article in German | MEDLINE | ID: mdl-7454752

Subject(s)

Promethazine/metabolism , Animals , Biotransformation , Rats , Sulfones/metabolism

3.

[Biotransformation of promazine]. / Zur Biotransformation von Promazin.

Bornschein, I; Pfeifer, S.

Pharmazie ; 35(7): 441, 1980.

Article in German | MEDLINE | ID: mdl-7413716

Subject(s)

Promazine/metabolism , Animals , Biotransformation , Male , Rats

4.

[Analysis and biochemistry of aza analogues of methaqualone. Part 7: biotransformation of 2-methyl-3-(2'-methylphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine (Kr 100) (author's transl)]. / Analytik und Biochemie von Azaanaloga des Methaqualons. Teil 7: Biotransformation von 2-Methyl-3-(2'-methylphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin (Kr 100).

Bornschein, I; Kraft, R; Pfeifer, S; Ullmann, M; Langner, H.

Pharmazie ; 34(11): 732-5, 1979 Nov.

Article in German | MEDLINE | ID: mdl-545343

Subject(s)

Methaqualone/analogs & derivatives , Animals , Biotransformation , Chemical Phenomena , Chemistry , Chromatography, Thin Layer , Male , Mass Spectrometry , Methaqualone/metabolism , Rats , Spectrophotometry, Ultraviolet

5.

[Biotransformation of promethazine (Prothazin)]. / Zur Biotransformation von Promethazin (Prothazin).

Bornschein, I; Pfeifer, S.

Pharmazie ; 34(11): 750, 1979 Nov.

Article in German | MEDLINE | ID: mdl-545346

Subject(s)

Promethazine/metabolism , Animals , Biotransformation , Male , Rats

6.

[Biotransformation of trapidil (Rocornal)]. / Biotransformation von Trapidil (Roncornal).

Bornschein, I; Pfeifer, S; Borchert, H H; Wierer, A; Woski, S; Köppel, H; Kraft, R; Rabitzsch, G.

Pharmazie ; 33(1): 51-63, 1978 Jan.

Article in German | MEDLINE | ID: mdl-566936

Subject(s)

Pyrimidines/metabolism , Trapidil/metabolism , Adult , Animals , Biotransformation , Dogs , Feces/analysis , Humans , Hydrolysis , In Vitro Techniques , Kinetics , Liver/metabolism , Male , Protein Binding , Rats , Species Specificity , Time Factors , Trapidil/urine

7.

[Mass spectrometry of 2-phenyl-4-[beta-dimethylaminoethyl]-6-methyl-2,3-dihydro-1,4-benzoxazine-3-one ("AR 17,048") and its metabolites]. / Massenspektrometrie von 2-Phenyl-4-[beta-dimethylaminoäthyl]-6-methyl-2.3-dihydro-1.4-benzoxazin-3-on ("AR 17 048") und seinen Metaboliten.

Bornschein, I; Gehrke, A; Pfeifer, S; Kraft, R.

Pharmazie ; 32(11): 695-7, 1977 Nov.

Article in German | MEDLINE | ID: mdl-609589

Subject(s)

Oxazines/analysis , Mass Spectrometry

8.

[Biotransformation of 2-phenyl-4-/beta-dimethylamino-ethyl/-6-methyl-2,3-dihydro-1,4-benzoxazine-3-one ("AR 17 O48) a potential antirheumatic agent]. / Biotransformation von 2-Phenyl-4-[beta-dimethylaminoäthyl]-6-methyl-2.3-dihydro-1.4-benzoxazin-3-on ("AR 17 048"), einem potentiellen Antirheumaticum.

Pfeifer, S; Bornschein, I; Gehrke, A.

Pharmazie ; 32(10): 587-92, 1977 Oct.

Article in German | MEDLINE | ID: mdl-607217

Subject(s)

Anti-Inflammatory Agents/metabolism , Biotransformation , Oxazines/metabolism , Administration, Oral , Animals , Anti-Inflammatory Agents/administration & dosage , Male , Oxazines/administration & dosage , Rats

9.

[Biotransformation of 9,9-dioxopromethazine (Prothanon)]. / Biotransformation von 9.9-Dioxopromethazin (Prothanon).

Borchert, H H; Bornschein, I; Pfeifer, S; Kraft, R.

Pharmazie ; 32(8-9): 489-96, 1977.

Article in German | MEDLINE | ID: mdl-594113

Subject(s)

Promethazine/analogs & derivatives , Animals , Biotransformation , Cyclic S-Oxides/analysis , Cyclic S-Oxides/metabolism , Hydroxylation , In Vitro Techniques , Kinetics , Liver/metabolism , Male , Mass Spectrometry , Oxidation-Reduction , Promethazine/analysis , Promethazine/metabolism , Rats

10.

[The biotransformation of trapidil (Rocornal)]. / Zur Biotransformation von Trapidil (Rocornal)

Bornschein, I; Borchert, H H; Wierer, A; Pfeifer, S.

Pharmazie ; 31(8): 578, 1976 Aug.

Article in German | MEDLINE | ID: mdl-996084

Subject(s)

Pyrimidines/metabolism , Trapidil/metabolism , Animals , Biotransformation , Dogs , Humans , Male , Rats

11.

[The biotransformation of 9,9-dioxopromethazine (prothanone)]. / Zur Biotransformation von 9.9-Dioxopromethazin (Prothanon)

Borchert, H H; Bornschein, I; Pfeifer, S.

Pharmazie ; 31(8): 579, 1976 Aug.

Article in German | MEDLINE | ID: mdl-996086

Subject(s)

Promethazine/analogs & derivatives , Animals , Biotransformation , In Vitro Techniques , Liver/metabolism , Male , Promethazine/metabolism , Rats

12.

[The serum protein binding of trapidil (Rocornal)]. / Zur Serumproteinbindung von Trapidil (Rocornal)

Gehrke, A; Leidreiter, B; Bornschein, I.

Pharmazie ; 31(8): 579-80, 1976 Aug.

Article in German | MEDLINE | ID: mdl-996087

Subject(s)

Pyrimidines/metabolism , Trapidil/metabolism , Blood Proteins/metabolism , Humans , In Vitro Techniques , Protein Binding

13.

[The biotransformation of 9,9-dioxopromethazine (Prothanon)]. / Zur Biotransformation von 9.9-Dioxopromethazin (Prothanon)

Borchert, H H; Bornschein, I; Pfeifer, S.

Pharmazie ; 31(2): 134-5, 1976.

Article in German | MEDLINE | ID: mdl-959258

Subject(s)

Promethazine/analogs & derivatives , Animals , Biotransformation , Feces/analysis , Promethazine/metabolism , Rats

14.

[Thin layer chromatographic detection of s-triazolo[1,5-a]pyrimidines and2-amino-1,2,4-triazole derivatives]. / Dünnschichtchromatographischer Nachweis von s-Triazolo [1.5-a]pyrimididinen und 3-Amino-1.2.4-triazolderivaten

Bornschein, I; Tenor, E.

Pharmazie ; 31(2): 135-6, 1976.

Article in German | MEDLINE | ID: mdl-959259

Subject(s)

Amitrole/analysis , Pyrimidines/analysis , Triazoles/analysis , Amitrole/analogs & derivatives , Chromatography, Thin Layer

15.

[Biotransformation of trapidil (Rocornal)]. / Zur Biotransformation von Trapidil (Rocornal)

Bornschein, I; Wierer, A; Borchert, H H; Pfeifer, S.

Pharmazie ; 31(1): 51, 1976.

Article in German | MEDLINE | ID: mdl-1257280

Subject(s)

Pyrimidines/urine , Trapidil/urine , Animals , Biotransformation , Dogs , Humans , Rats , Trapidil/administration & dosage

16.

[Biotransformation of trapidil (Rocornal)]. / Zur Biotransformation von Trapidil (Rocornal)

Bornschein, I; Pfeifer, S.

Pharmazie ; 31(1): 53-4, 1976.

Article in German | MEDLINE | ID: mdl-1257284

Subject(s)

Pyrimidines/metabolism , Trapidil/metabolism , Triazoles/isolation & purification , Biotransformation , Mass Spectrometry , Molecular Conformation , Pyrimidines/isolation & purification

17.

[The distribution of trapidil (Rocornal) in rat organs]. / Zur Verteilung von Trapidil (Rocornal) im Organismus der Ratte

Borchert, H H; Gantert, E; Bornschein, I; Pfeifer, S.

Pharmazie ; 30(9): 615-6, 1975 Sep.

Article in German | MEDLINE | ID: mdl-1187748

Subject(s)

Pyrimidines/metabolism , Trapidil/metabolism , Adipose Tissue/metabolism , Animals , Brain/metabolism , Gastric Mucosa/metabolism , Injections, Intravenous , Intestine, Large/metabolism , Intestine, Small/metabolism , Kidney/metabolism , Liver/metabolism , Lung/metabolism , Male , Muscles/metabolism , Myocardium/metabolism , Rats , Spleen/metabolism , Time Factors , Trapidil/administration & dosage

18.

[Biotransformation of iomeglamic acid (Falignost)]. / Zur Biotransformation von Iomeglamsäure (Falignost¿)

Bornschein, I; Schäffner, J; Pfeifer, S.

Pharmazie ; 30(3): 196, 1975 Mar.

Article in German | MEDLINE | ID: mdl-1153481

Subject(s)

Contrast Media/urine , Iodobenzenes/urine , Aniline Compounds/urine , Biotransformation , Chromatography, Thin Layer , Glutarates/urine , Humans , Male

19.

[The biotransformation of trapidil (Rocornal)]. / Zur Biotransformation von Trapidil (Rocornal)

Bornschein, I; Wierer, A; Pfeifer, S; Köppel, H.

Pharmazie ; 30(12): 806-7, 1975 Dec.

Article in German | MEDLINE | ID: mdl-1219805

Subject(s)

Pyrimidines/metabolism , Trapidil/metabolism , Animals , Biotransformation , Male , Rats

20.

[Mass spectrometry of s-triazolo(1.5-a)pyrimidine derivatives]. / Massenspektrometrie von s-Triazolo(1.5-a)pyrimidinderivaten

Wierer, A; Kraft, R; Bornschein, I; Pfeifer, S.

Pharmazie ; 29(10-11): 692-6, 1974.

Article in German | MEDLINE | ID: mdl-4438410

Subject(s)

Pyrimidines , Vasodilator Agents , Chemical Phenomena , Chemistry , Mass Spectrometry , Triazoles

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