[Narrow-band medium-wave ultraviolet therapy in patients with atopic dermatitis: efficacy and safety]. / Uzkopolosnaya srednevolnovaya ul'trafioletovaya terapiya bol'nykh atopicheskim dermatitom: effektivnost' i bezopasnost'.

For the treatment of patients with atopic dermatitis of moderate and heavy severity level, narrow-band medium-wave ultraviolet therapy (narrow-band phototherapy) can be used. An analysis of the results of studies of the efficacy and safety of narrow-band medium-wavelength ultraviolet therapy in patients with atopic dermatitis is presented, and a characteristic of the regimens of the phototherapy carried out is given. It has been shown that narrow-band phototherapy is an effective and safe method of treating patients with atopic dermatitis, but its effectiveness varies widely. Data were obtained on the absence of an increase in the effect during therapy with higher doses of radiation, about the higher efficiency of narrow-band phototherapy with concurrent medication, with an increase in the number of irradiation procedures, as well as in patients with a higher minimum erythemal dose, which indicates the possible existence of factors characterizing the individual characteristics of the response of patients to narrow-band phototherapy.

[Role of the skin expression of neuropeptides, neurotrophins and their receptors in the pathogenesis of dermatoses].

OBJECTIVE: to define the role of neurotransmitters and their receptors in the development of itch and in the maintenance of a skin inflammatory response in patients with psoriasis and atopic dermatitis. MATERIAL AND METHODS: Skin biopsy specimens from 30 patients with psoriasis and 30 patients with atopic dermatitis were investigated by histological, immunoperoxidase, and indirect immunofluorescence assays. The investigators determined the expression of protein gene product 9.5 (PGP9.5), amphiregulin, semaphorin 3A, calcitonin gene-related peptide (CGRP) and its receptor (CGRP-R), nerve growth factor (NGF) and its receptor TrkA, and substance P (SP) and its receptor SP-R. The indirect immunofluorescence assay was used for quantitative analysis. The findings were statistically analyzed using a Statistica 10 program. RESULTS: Immunoperoxidase examination of the skin biopsy specimens from patients with atopic dermatitis and psoriasis revealed enhanced expression of amphiregulin, NGF, and PGP9.5, appearance of positively stained epidermal nerve fibers, and decreased expression of the nerve reduction factor semaphorin 3A in all cases. Some patients with atopic dermatitis and psoriasis showed increased expression of CGRP and CGRP-R, SP, SP-R, and TrkA. A pronounced inflammatory response was generally observed in these cases. CONCLUSION: The investigation performed suggests that atopic dermatitis and psoriasis are characterized by a larger number of epidermal nerve fibers and by a direct correlation between this indicator, disease severity, and itch intensity. The production of neuropeptides and neurotrophins is closely related to the development of a skin inflammatory response irrespective of its cause and dysregulation of these processes is likely to favor the body's sensitization and the chronic pattern the course of diseases.

Expression of Neuropeptides, Neurotrophins, and Neurotransmitters in the Skin of Patients with Atopic Dermatitis and Psoriasis.

Expression of neural marker PGP9.5, amphiregulin, semaphorin-3A, calcitonin gene-related peptide and its receptor, nerve growth factor and its receptor, substance P and its receptor, and expression frequency were analyzed in biopsy specimens from patients with atopic dermatitis and psoriasis and healthy volunteers by immunohistochemical method. Nerve fibers penetrated into the epidermis more frequently, and amphiregulin expression was significantly higher in patients with atopic dermatitis and psoriasis comparing to the control. Expression of semaphorin-3A in patients with atopic dermatitis was less frequent than in the control. These findings reflect the involvement of amphiregulin and semaphorin-3A in the improvement of skin innervations and penetration of nerve fibers into the epidermis, and due of which these proteins mediate the development of itch.

[New prospects in therapy of occupational allergic dermatoses (review of literature)].

Occupational allergic skin diseases carry significant social and economic importance. They are characterized by chronic relapsing course and resistance to treatment. That necessitates new therapeutic modalities for occupational allergic dermatoses. Zincum could interfere into a process of allergic inflammation development. Using zincum preparations is pathogenetically justified in occupational allergic dermatoses treatment.

[Advances in prophylaxis of occupational dermatoses]. / Novoe v profilaktike professional'nykh dermatozov.

The article deals with contemporary prophylactic methods for occupational dermatoses. The authors stress importance of etiologic approach to creation of prophylactic measures complex at various industrial enterprises.

[Features of dermatoses development in workers contacting irritants and allergens]. / Osobennosti razvitiia dermatozov u rabotaiushchikh v kontakte s veshchestvami, obladaiushchimi razdrazhaiushchim i allergennym deistviem.

Occupational hazards are characterized by low intensity and combined effects depicted in signs of occupational diseases. Effects of facultative irritants on development and course of occupational skin allergies are studied through example of organic solvents.

[Toxic vinyl chloride related melanodermia]. / Toksicheskaia melanodermiia, vyzvannaia vinilkhloridom.

The case of toxic melanoderma in female patient 32 years aged is described. The erythematous and pigmented lesions are present on the face, neck and upper part of breast. The disease developed after 4 months exposure to vinilchloride in workplace. The diagnosis was made in 2 years after the beginning of the disease.