Naphthobisthiadiazole-Based π-Conjugated Polymers for Nonfullerene Solar Cells: Suppressing Intermolecular Interaction Improves Photovoltaic Performance.

Naphthobisthiadiazole has been known as a promising building unit of π-conjugated polymers for organic photovoltaics (OPVs). Here, we synthesized new NTz-based polymers that were combined with a benzodithiophene (BDT) unit having alkylthienyl substituents in the polymer backbone, named PNTzBDT, and PNTzBDT-F and PNTzBDT-Cl with fluorine and chlorine groups in the substituents, respectively. The polymers had significantly improved solubility than the previously reported NTz-based polymer (PNTz4T), most likely due to the torsion of the alkylthienyl substituents with respect to the BDT moiety, which suppresses the intermolecular interaction between the backbones. Despite the lower intermolecular interaction and thereby lower crystallinity, these polymers, in particular PNTzBDT and PNTzBDT-F, exhibited higher photovoltaic performances, with power conversion efficiencies as high as 13.3%, than PNTz4T in the cells that used Y6 as the acceptor material. The improved performance was ascribed to the enhanced miscibility of the polymers with the nonfullerene acceptor due to the increased solubility, which in addition led to the better charge generation and reduced charge recombination. These results indicate that NTz-based π-conjugated polymers have high potential for nonfullerene-based OPVs.

Surface PEGylation via Ultrasonic Spray Deposition for the Biofouling Mitigation of Biomedical Interfaces.

Air plasma and spray technology are common methods for surface modification. In this study, air plasma is used to generate hydroxyl groups on various material surfaces. Then random copolymers of styrene and ethylene glycol methacrylate (PS-r-PEGMA) are spray-coated to achieve coating densities ranging between 0.1 and 0.6 mg/cm2. PS50-r-PEGMA50 led to the best overall antifouling properties, while a coating density of 0.3 mg/cm2 was enough to significantly reduce biofouling. This surface modification technique enabled efficient modification of a wide range of materials and biofouling reduction by at least 75% on polymeric surfaces (polystyrene, polyvinylidene fluoride, poly(tetrafluoroethylene), polydimethylsiloxane), metallic surfaces (steel, titanium alloy), or ceramic surface (glass). Applied to the modification of well plate used for blood-typing, this antifouling modification permitted to greatly increase the signal sensitivity (×4).

Scalable Ultrasonic Spray-Processing Technique for Manufacturing Large-Area CH3NH3PbI3 Perovskite Solar Cells.

Organic-inorganic hybrid perovskite solar cells are on the brink of a breakthrough in photovoltaic technology. Scale-up and large-area processing have become the focal points that must be resolved before commercialization. In this study, the scalable ultrasonic spray deposition method for high-throughput coating of the perovskite photoactive layer with a large active area of up to 3 cm2 is implemented by precisely controlling the concentration of the precursor solution and spray passes. CH3NH3PbI3 films with large crystallites and a suitable thickness of ∼350 nm are facilely developed through one-step direct ultrasonic spraying. Less hysteresis and highly reproducible power conversion efficiencies (PCEs) of up to 12.30% (11.43 ± 0.43% on average for 20 devices) are achieved by an optimized single-junction device with an active area of 1 cm2, along with good ambient stability. The device retained ∼80 and ∼65% of the initial PCE after 60 and 105 days in ambient, respectively. The ultrasonic spray-coated perovskite solar cells can be further scaled to larger areas of 2 and 3 cm2 and exhibit PCEs of 10.18 and 7.01%, respectively. The reliable scale-up process for manufacturing the atmospheric wet-coated perovskite film is available in cost-effective and easily operated bench-top variants to bridge the interconnection between applied research and industry.

Comparison of IHC, FISH and RT-PCR methods for detection of ALK rearrangements in 312 non-small cell lung cancer patients in Taiwan.

BACKGROUND: Recently Echinoderm microtubule-associated protein-like 4- anaplastic lymphoma kinase (EML4-ALK) fusion gene has become an important biomarker for ALK tyrosine kinase inhibitor (crizotinib) treatment in NSCLC. However, the best detection method and the significance of EML4-ALK variant types remain uncertain. METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR), fluorescence in Situ hybridization (FISH) and Immunohistochemical (IHC) stain were performed on tumor tissues of 312 NSCLC patients for detection of ALK rearrangements. Mutation analyses for EGFR and KRAS genes were also performed. RESULTS: Thirteen of the 312 patients (4.17%) had ALK rearrangements detected by RT-PCR. If RT-PCR data was used as the gold standard, FISH tests had a low sensitivity (58.33%), but very good specificity (99.32%). IHC stain had better sensitivity (91.67%) than FISH, but lower specificity (79.52%), when the cut off was IHC2+. All of the 8 patients with high abundance of EML4-ALK positive cells in tumor tissues (assessed by the signal intensities of the RT-PCR product), were also have high expression of ALK protein (IHC3+), and positive for FISH, except one failed in FISH. Variants 3a+3b (4/5, 80%) of EML4-ALK fusion gene were more common to have high abundance of EML4-ALK positive cells in tumor tissues than variant 1 (1/3, 33.3%). Meta-analysis of the published data of 2273 NSCLC patients revealed that variant 3 (23/44, 52.3%) was the most common type in Chinese population, while variant 1 (28/37, 75.7%) was most common in Caucasian. CONCLUSIONS: Among the three detection methods, RT-PCR could detect not only the presence of EML4-ALK fusion gene and their variant types, but also the abundance of EML4-ALK positive cells in NSCLC tumor tissues. The latter two factors might affect the treatment response to anti-ALK inhibitor. Including RT-PCR as a diagnostic test for ALK inhibitor treatment in the prospective clinical trials is recommended.