ABSTRACT
BACKGROUND: Radiofrequency ablation (RFA) is an emerging treatment for primary aldosteronism owing to aldosterone-producing adenoma. Whether RFA could be an alternative treatment to laparoscopic adrenalectomy is unknown. METHODS: This was a retrospective comparative study in patients with aldosterone-producing adenoma undergoing either laparoscopic adrenalectomy or CT-guided percutaneous RFA between 2004 and 2012. Short-term outcomes and long-term resolution rates of primary aldosteronism (normalized aldosterone to renin ratio), hypokalaemia and hypertension (BP lower than 140/90 mmHg without antihypertensive medical therapy) were evaluated. RESULTS: Some 63 patients were included, 27 in the laparoscopic adrenalectomy group and 36 in the RFA group. RFA was associated with shorter duration of operation (median 12 versus 124 min; P < 0·001), shorter hospital stay (2 versus 4 days; P < 0·001), lower analgesic requirements (13 of 36 versus 23 of 27 patients; P < 0·001) and earlier resumption of work (median 4 versus 14 days; P = 0·006). Morbidity rates were similar in the two groups. With median follow-up of 5·7 (range 1·9-10·6) years, resolution of primary aldosteronism was seen in 33 of 36 patients treated with RFA and all 27 patients who had laparoscopic adrenalectomy (P = 0·180). Hypertension was resolved less frequently after treatment with RFA compared with laparoscopic adrenalectomy (13 of 36 versus 19 of 27 patients; P = 0·007). Hypokalaemia was resolved in all patients. CONCLUSION: For patients with aldosterone-producing adenoma the efficacy of resolution of primary aldosteronism and hypertension was inferior after treatment with RFA compared with laparoscopic adrenalectomy.
Subject(s)
Adenoma/surgery , Adrenal Gland Neoplasms/surgery , Adrenalectomy/methods , Laparoscopy/methods , Laser Therapy/methods , Adenoma/diagnosis , Adenoma/metabolism , Adolescent , Adrenal Gland Neoplasms/diagnosis , Adrenal Gland Neoplasms/metabolism , Adult , Aftercare , Aged , Aged, 80 and over , Aldosterone/metabolism , Female , Humans , Hyperaldosteronism/diagnosis , Hyperaldosteronism/surgery , Hypertension/etiology , Hypertension/surgery , Length of Stay/statistics & numerical data , Magnetic Resonance Imaging , Male , Middle Aged , Operative Time , Postoperative Complications/etiology , Retrospective Studies , Tomography, X-Ray Computed , Treatment Outcome , Young AdultABSTRACT
OBJECTIVE: To evaluate the efficacy of laparoscopic adjustable gastric banding in the management of morbid obesity in a cohort of Chinese patients. DESIGN. Cohort study. SETTING: University teaching hospital, Hong Kong. PATIENTS: From August 2002 to September 2003, 10 patients (6 male, 4 female) with a median age of 34 years (range, 23-48 years) underwent laparoscopic adjustable gastric banding to treat morbid obesity. Considerable co-existing diseases were present in 90% of the cases. We instituted a team approach that allowed every patient to see our dietitian, physician, psychiatrist (if necessary), and surgeon prior to deciding on the procedure to be used. MAIN OUTCOME MEASURES: Excessive body weight loss, quality-of-life score (SF36), and co-morbidities improvement. RESULTS: The 10 patients had a median weight of 127 kg (range, 115-196 kg) and median body mass index of 47 kg/m(2) (range, 38-67 kg/m(2)). The operation was successful in all patients with a median operating time of 110 minutes (range, 75-240 minutes). The median hospital stay was 3 days (range, 3-4 days) and three of the patients required overnight observation in the intensive care unit because of severe sleep apnoea and asthma. The median follow-up period was 12 months (range, 1-18 months). The mean weight loss at 6, 12, and 18 months was 19.3, 22.4, and 25.9 kg, respectively. Mean percentage of excessive weight loss at 6, 12, and 18 months was 34.9%, 36.5%, and 40.5%, respectively. Unsatisfactory weight loss (<20 kg) occurred in three patients because of poor dietary compliance and non-follow-up. Surgery also considerably improved the patients' co-morbidities (hypertension, diabetes, and obstructive sleep apnoea) and the quality of life. CONCLUSION: In the short term, laparoscopic adjustable gastric banding is certainly an effective procedure for morbid obesity, which results in a substantial weight loss and improvement of co-existing morbidities. Longer follow-up will show whether this weight loss is maintainable.
Subject(s)
Gastroplasty , Laparoscopy , Obesity, Morbid/surgery , Adult , Asian People , Cohort Studies , Diabetes Complications/prevention & control , Female , Hong Kong , Humans , Hypertension/complications , Hypertension/therapy , Length of Stay , Male , Middle Aged , Obesity, Morbid/complications , Osteoarthritis, Knee/complications , Osteoarthritis, Knee/therapy , Quality of Life , Sleep Apnea, Obstructive/complications , Sleep Apnea, Obstructive/therapy , Treatment Outcome , Weight LossABSTRACT
Oxalate urolithiasis in male rats was experimentally induced by feeding a basal diet composed of Purina laboratory chow and 3 per cent glycolic acid. When this basal oxalate calculus-producing diet containing 10 per cent alanine was fed to rats, the incidence of oxalate urolithiasis was markedly reduced. Moreover, when Purina laboratory chow containing 10 per cent alanine was fed to rats which had been on the calculi-producing basal diet for 4 weeks, it appeared that most uroliths were dissolved. Excess intake of alanine increased the concentration of alanine in urine and this apparently aided in the prevention and treatment of urolithiasis.
