1.
Molecules
; 26(7)2021 Apr 06.
Article
in English
| MEDLINE
| ID: mdl-33917636
ABSTRACT
Pentacyclic triterpenoids oleanolic acid, ursolic acid, betulinic acid, and platanic acid were acetylated and converted into several amides 9-31; the cytotoxicity of which has been determined in sulforhodamine B assays employing seral human tumor cell lines and nonmalignant fibroblasts. Thereby, a betulinic acid/trans-1,4-cyclohexyldiamine amide showed excellent cytotoxicity (for example, EC50 = 0.6 µM for HT29 colon adenocarcinoma cells).