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Bioorg Med Chem Lett
; 20(10): 3026-30, 2010 May 15.
Article
in English
| MEDLINE
| ID: mdl-20443225
ABSTRACT
Using AMD070 as a starting point for structural modification, a novel series of isoquinoline CXCR4 antagonists was developed. A structure-activity scan of alternate lower heterocycles led to the 3-isoquinolinyl moiety as an attractive replacement for benzimidazole. Side chain optimization in the isoquinoline series led to a number of compounds with low nanomolar anti-HIV activities and promising rat PK properties.