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Mater Sci Eng C Mater Biol Appl ; 101: 404-414, 2019 Aug.
Article in English | MEDLINE | ID: mdl-31029334

ABSTRACT

The synthesis of bioactive CuO/C nano composite using sucrose as a capping agent is achieved through simple green approach via Response Surface Methodology. The synthesis process was done in a green environment which prevents aggregation of sucrose and promotes nanoparticles formation. The innovative approach produces sucrose as a carbon source mediated copper oxide nanocomposites (CuO/C nanocomposite) with the particle size of 50 nm. Additionally, the produced CuO/C nanocomposite were characterized using microscopic techniques like SEM, TEM and spectroscopic techniques like UV-vis and X-ray diffraction. The antifungal activities of CuO/C nanocomposite were tested against Aspergillus niger and Aspergillus flavus species. At 1000 ppm of CuO/C nanocomposite, it showed 70% restraint on A. flavus and 90% hindrance on A. niger. The fungal inhibition mechanism of bioactive CuO/C nanocomposite was discussed in this research article. The particular high antifungal performance of CuO/C nanocomposite was found against Aspergillus niger while compare to Aspergillus flavus fungal strain.


Subject(s)
Antifungal Agents/pharmacology , Carbon/pharmacology , Copper/pharmacology , Nanocomposites/chemistry , Sucrose/pharmacology , Analysis of Variance , Aspergillus/drug effects , Hemolysis/drug effects , Humans , Microbial Sensitivity Tests , Nanocomposites/ultrastructure , Regression Analysis , Spectrophotometry, Ultraviolet , Spectroscopy, Fourier Transform Infrared
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