ABSTRACT
El presente estudio pretende identificar correlaciones estadísticamente significativas entre parámetros de masa grasa abdominal obtenidos por densitometría (DXA) y otros de tipo cineantropométrico (índices de distribución de masa grasa) y bioquímico (perfil lipídico) en mujeres postmenopausicas con síndrome metabólico. Se diseño un estudio de cohortes histórico que incluyó a un total de 1326 mujeres post-menopausicas con edad > 45 años que se habían sometido rutinariamente a DXA para conocer su densidad mineral ósea entre Enero de 2006 y Enero de 2011. Se utilizó un DXA tipo Lunar DPX-L para determinar la masa grasa abdominal en las regiones de interés L1-L4 y L3-L4. Además del DXA, se obtuvo de cada participante la correspondiente anamnesis, bioquímica, tensión arterial e índices de distribución de masa grasa mediante técnicas antropométricas convencionales. Se utilizó la clasificación NCEP-ATP-III para el diagnóstico de síndrome metabólico. Este protocolo fue aprobado por un Comité de Ética Institucional. La mayor fuerza de asociación se estableció entre el porcentaje de masa grasa L1-L4 obtenido por DXA y el perímetro de la cintura (r= 0,77; p= 0,0016) además de con colesterol-HDL (r= -0,58; p= 0,0290). Finalmente se concluye que el perímetro de la cintura y los niveles de colesterol-HDL podrían recomendarse como predictores del comportamiento de la masa grasa abdominal de regiones de interés L1-L4 y L3-L4 obtenidas por DXA en mujeres postmenopausicas con síndrome metabólico.
The current study was conducted to identify potential correlations between abdominal fat mass obtained by DXA and several parameters obtained by anthropometric conventional techniques as well as lipid profile in postmenopausal women with MS. This historical cohort study included a total of 1326 postmenopausal women aged > 45 years old who had routinely undergone DXA to measure their bone mineral density between January 2006 and January 2011. The regions of interest envisaged in our study by using DXA were the lumbar regions L1-L4 and L4-L5. At the same time, they underwent a complete medical examination including personal medical history assessment, biochemical blood analysis, blood pressure measurements and anthropometrical evaluation. Metabolic syndrome was diagnosed attending to the criteria established by National Cholesterol Education Program Adult Treatment Panel III (NECP-ATP-III). This protocol was approved by an Institutional Ethics Committee. Several significant correlations were found between DXA and indices of body fat distribution as well as lipid profile. The strongest correlations were found between fat mass L1-L4 and waist circumference (r= 0.77; p= 0.0016) and levels of HDL-cholesterol (r= -0.58; p= 0.0290). It was concluded that waist circumference and HDL-cholesterol may be recommended to predict fat mass in regions of interest L1-L4 and L3-L4 in postmenopausal women with MS.
Subject(s)
Humans , Female , Middle Aged , Abdominal Fat/anatomy & histology , Metabolic Syndrome , Postmenopause , Absorptiometry, Photon , Anthropometry , Densitometry , Retrospective StudiesABSTRACT
PIP: The authors studied the effects of the use of combined pills on serum prolactin (PRL) levels. Serum PRL levels were determined by radioimmunoassay in 9 women using combined pills for at least 6 months. Each woman was sampled 6 times during the month of study. The authors conclude that combined pills increase PRL serum levels in a much higher proportion than the spontaneous incidence of hyperprolactinemia and suggest that this effect is strongly related to the length of pill use. (author's modified)^ieng
Subject(s)
Contraception , Contraceptive Agents, Female , Contraceptives, Oral, Combined , Contraceptives, Oral , Gonadotropins, Pituitary , Hormones , Prolactin , Reproductive Control Agents , Biology , Contraceptive Agents , Endocrine System , Family Planning Services , Gonadotropins , Physiology , Pituitary HormonesABSTRACT
Os autores estudam os efeitos do uso de pilulas anticoncepcionais combinadas no nivel sanguineo de prolactina (PRL). Em nove mulheres usando pilulas anticoncepcionais combinadas por seis meses ou mais determinou-se a prolactinemia por radioimunoensaio, em seis amostras colhidas durante o mes do estudo. Os autores concluem que os anticoncepcionais orais combinados elevam a prolactinemia numa proporcao bem maior que a incidencia espontanea de hiperprolactinemia e sugerem que o tempo de uso e importante na producao deste efeito