ABSTRACT
El objetivo de este trabajo fue evaluar las diferentes alteraciones renales morfológicas y funcionales secundarias a la pérdida de la masa renal por nefrectomía subtotal (Nx5/6) e investigar los mecanismos patogénicos involucrados en el daño TI en este modelo.Se utilizaron machos Sprague-Dawley (280-290 g) divididos en dos grupos. GI, (Nx5/6) N=15 y G2, (Sham) n= 15, los que fueron sometidos a una operación simulada "sham operation". La duración del experimento fue 24 semanas obteniéndose en el período basal y cada 4 semanas hasta la finalización del estudio, registros de presión arterial (PA) y muestras de sangre y orina. Los resultados indicaron que este modelo de nefrectomía subtotal, produce en 24 semanas un DRC con ascenso de la PA correlacionándose significativamente con el ascenso de la creatininemia
Subject(s)
Animals , Rats , Nephrectomy , Kidney/physiopathologyABSTRACT
El objetivo de este trabajo fue evaluar las diferentes alteraciones renales morfológicas y funcionales secundarias a la pérdida de la masa renal por nefrectomía subtotal (Nx5/6) e investigar los mecanismos patogénicos involucrados en el daño TI en este modelo.Se utilizaron machos Sprague-Dawley (280-290 g) divididos en dos grupos. GI, (Nx5/6) N=15 y G2, (Sham) n= 15, los que fueron sometidos a una operación simulada "sham operation". La duración del experimento fue 24 semanas obteniéndose en el período basal y cada 4 semanas hasta la finalización del estudio, registros de presión arterial (PA) y muestras de sangre y orina. Los resultados indicaron que este modelo de nefrectomía subtotal, produce en 24 semanas un DRC con ascenso de la PA correlacionándose significativamente con el ascenso de la creatininemia
Subject(s)
Animals , Rats , Kidney/physiopathology , NephrectomyABSTRACT
Struvite renal stones are caused by infection of the urine with bacteria that synthesize the enzyme urease. Ammonium is released by the breakdown of urea by urease, the urine becomes highly alkaline, and magnesium ammonium phosphate (struvite) and carbonate apatite crystallize. Incorporation of the infecting bacteria within the developing stone, results in a focus of infection that is resistant to conventional antimicrobial therapy, and which is manifested clinically by repeated urinary tract infection caused by persistent bacteriuria. Extracorporeal shock wave lithotripsy (ESWL) currently is accepted as the election treatment for most renal calculi. This trial examines the bacteriologic aspects pre and post-ESWL. Eighty adult patients, 47 females and 33 males, without clinical signs of urinary tract infections (UTI) were submitted to urine cultures pre and post-ESWL. The first 50 patients underwent during and post-ESWL, 150 blood cultures, which all proved to be negative, confirming very low risk of generalized sepsis. No patient presented fever, chills or rigors pre or postprocedures. With respect to urine cultures 43 patients (52.5%) had a pre-ESWL UTI, in comparison to 49 (60%) who had a UTI post-ESWL. The distribution of organisms pre and post-ESWL was as follows: Proteus mirabilis (22/22), Escherichia coli (11/11), Pseudomonas aeruginosa (4/5), Klebsiella pneumoniae (2/2), Enterobacter cloacae (0/1), Alcaligenes odorans (1/2) Enterococcus faecalis (1/3), Staphylococcus saprophyticus (1/2) and Candida albicans (1/1). In this study 6 patients presented bacteriuria post-ESWL probably due to bacteria from inside the calculi. According to these results, the risk of bacteremia seems to be very low. In 60% of staghorn renal stones we could demonstrate a bacterial infection.
Subject(s)
Bacterial Infections/etiology , Kidney Calculi/therapy , Kidney Calices , Lithotripsy/adverse effects , Urinary Tract Infections/etiology , Adult , Female , Humans , Kidney Calculi/microbiology , MaleABSTRACT
Struvite renal stones are caused by infection of the urine with bacteria that synthesize the enzyme urease. Ammonium is released by the breakdown of urea by urease, the urine becomes highly alkaline, and magnesium ammonium phosphate (struvite) and carbonate apatite crystallize. Incorporation of the infecting bacteria within the developing stone, results in a focus of infection that is resistant to conventional antimicrobial therapy, and which is manifested clinically by repeated urinary tract infection caused by persistent bacteriuria. Extracorporeal shock wave lithotripsy (ESWL) currently is accepted as the election treatment for most renal calculi. This trial examines the bacteriologic aspects pre and post-ESWL. Eighty adult patients, 47 females and 33 males, without clinical signs of urinary tract infections (UTI) were submitted to urine cultures pre and post-ESWL. The first 50 patients underwent during and post-ESWL, 150 blood cultures, which all proved to be negative, confirming very low risk of generalized sepsis. No patient presented fever, chills or rigors pre or postprocedures. With respect to urine cultures 43 patients (52.5
) had a pre-ESWL UTI, in comparison to 49 (60
) who had a UTI post-ESWL. The distribution of organisms pre and post-ESWL was as follows: Proteus mirabilis (22/22), Escherichia coli (11/11), Pseudomonas aeruginosa (4/5), Klebsiella pneumoniae (2/2), Enterobacter cloacae (0/1), Alcaligenes odorans (1/2) Enterococcus faecalis (1/3), Staphylococcus saprophyticus (1/2) and Candida albicans (1/1). In this study 6 patients presented bacteriuria post-ESWL probably due to bacteria from inside the calculi. According to these results, the risk of bacteremia seems to be very low. In 60
of staghorn renal stones we could demonstrate a bacterial infection.
Subject(s)
Adult , Middle Aged , Humans , Male , Female , Calcium , Femoral Fractures , Parathyroid Hormone , Serum Albumin , Femur HeadSubject(s)
Adult , Middle Aged , Aged , Humans , Male , Female , Serum Albumin , Calcium , Femoral Fractures , Parathyroid Hormone , Femur HeadSubject(s)
Cross Infection/epidemiology , Hepatitis B/transmission , Personnel, Hospital , Renal Dialysis/adverse effects , Adult , Aged , Biopsy , Blood Protein Electrophoresis , Female , Hepatitis B Surface Antigens/analysis , Humans , Liver/pathology , Male , Middle Aged , Prognosis , Transaminases/analysisSubject(s)
Liver/pathology , Lymphoma/pathology , Adult , Aged , Autoantibodies/analysis , Bone Marrow/pathology , Female , Glucose-6-Phosphate Isomerase/analysis , Hepatitis B Surface Antigens/analysis , Humans , L-Lactate Dehydrogenase/analysis , Liver/physiopathology , Lymphoma/enzymology , Lymphoma/immunology , Male , Middle Aged , UltrasonographyABSTRACT
Thirty-one patients HBs Ag negative seen between january 1978 and june 1980 were studied. Twenty-four of them were males and seven females. Their age ranged between 13 and 58 years. All of them were anti-HAV IgM negative. Six patients presented simultaneously Anti HBc and Anti HBs in the two first weeks of the illness. This fact could be imputed to an acquired immunity due to a previous infection with virus B. None of the patients studied had evidence of infectious mononucleosis or cytomegalovirus. In view of the absence of the markers of recent infection due to virus A and B these patients were considered to have a non A non B hepatitis. Twelve patients had evidence of previous hepatitis, thirteen had acquired the infection by parenteral route; four were post-transfusional and in six cases there was an epidemic medium. Forty-five percent of the patients studied had a biphasic elevation of the aminotransferases, and twenty percent had a cholestatic form. Two of the patients turned into a chronic active hepatitis and another one died of submasive necrosis; in both cases the via of infection was parenteral.