[The medical treatment of condylomatosis of the lower genital tract. A multicenter outpatient study]. / Trattamento medico della condilomatosi del basso tratto genitale. Studio policentrico ambulatoriale.

Beta-interferone (Frone, Serono) has been used to treat 56 patients with clinical diagnosis of genital condylomatosis in quantity of 3 million UI/die. Controls have been effected at 3 months since the end of therapy. 30 patients were cured after 3 months of therapy, while at 6 months follow-up we have reported a complete regression in 78.6% of cases.

[New pharmacological approach to therapy of perimenopausal meno-metrorrhagia. Vaginal use of progesterone]. / Nuovo approccio farmacologico alla terapia delle meno-metrorragie peri-menopausali. Utilizzo del progesterone per via vaginale.

The authors evaluate the effectiveness of a therapy based on natural progesterone to be employed as a vaginal cream in the treatment of meno-metrorrhagia in peri-menopause in 40 patients who were not prepared to consider surgery as a solution for their problems. In the polycentric out-patient study this new preparation has proved to be efficacious and to induce a regression of the endometrial hyperplasia in more than 90% of patients subject to five months' treatment.

[Treatment with GnRH analogs in polycystic ovarian disease. A collaborative multicenter study. The preliminary results]. / Il trattamento con analoghi del GnRH della malattia policistica dell'ovaio. Studio policentrico collaborativo. Risultati preliminari.

The study evaluates the efficacy of tryptorelin treatment in cases of acne and hirsutism associated with polycystic ovarian (PCO) disease. This non-comparative open study in a sample population of 20 young patients who wished to have children demonstrates the reduction of the hirsutism and acne score after six months' treatment. Tryptorelin was even capable of normalizing the hematic hormonal levels examined and ovarian function following six months of treatment, as well as at an initial follow-up after three months. The authors state their intention of performing a larger trial in order to observe the real efficacy of tryptorelin in a study which includes a 12-month follow-up to assess the pregnancy rate.

[Therapy of simple endometrial hyperplasia with GnRH analogs. Evaluation of a multicentric ambulatory study. Preliminary results]. / Trattamento con GnRH analoghi della iperplasia endometriale semplice. Valutazione di uno studio policentrico ambulatoriale. Risultati preliminari.

Endometrial hyperplasia is a frequent pathology during menopause and involves the risk of malignant transformation of the lesions. In an attempt to avoid radical surgery, this study proposes the use of triptorelin which was used to treat 56 patients with histologically confirmed symptoms of endometrial hyperplasia without atypia. GnRH-analog was administered using the intramuscular route every 28 days for 6 months. Histological controls were carried out 30 days after the last injection and showed the resolution of histological symptoms, confirmed after three months.

[Fluconazole in the treatment of vaginitis caused by Candida albicans]. / II Fluconazolo nel trattamento delle vaginiti sostenute da Candida albicans.

The authors verified the local activity and tolerance of the antimycotic drug Fluconazole in 125 cases of women suffering from clinical diagnosed vulvovaginitis caused by Candida albicans. Results were positive with regard to the efficacy and safety of the treatment.

[The effect of two contraceptive methods (EP vs. IUD) in relation to inflammatory changes and CIN]. / L'influenza di due metodiche contraccettive (EP versus IUD) nei confronti di alterazioni infiammatorie e CIN.

The authors examine Smear Test phlogistic picture repair processes, endometrial cells and preneoplastic lesions in women who used IUD and EP. The research has pointed out that infection due to Actinomyces is only (present) in IUD carriers. CIN affects for 4.2% of IUD carriers.

[Use of sulprostone in nulliparous patients in voluntary interruption of pregnancy during the first trimester]. / Uso del sulprostone in pazienti nullipare nel corso di I.V.G. del primo trimestre.

A new PGE2 derivate, sulprostone, is described in detail. The drug was used to induce abortion in 68 patients in the first three months of pregnancy. It was administered intramuscularly, in a single dose of 500 mcg. The results obtained clearly reveal sulprostone to be an effective drug, easily handled and well tolerated.